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Nutraceuticals in Cancer Therapy

Challenges and Opportunities

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  • First Online:
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Cancer is known globally as a fatal disease with only minor progress done in reducing its morbidity and mortality. Still the exact reasons that predispose to cancer are not well defined; however incorrect diet, genetic makeup, and environmental factors could be considered as risk factors. Over 95% of cancers are triggered by lifestyle and might take up to 20–30 years to develop. Natural products have long been considered as enriched source of anticancer agents with diverse constitution, configuration, and bioactivities. Within the cancer field of research, many drug products in the market have been discovered from nature, by making modifications to the structures of the isolated natural products or by taking them as lead compounds to synthesize novel scaffolds. Nutraceuticals are phytochemicals derived from dietary or herbal origin. They can significantly induce apoptosis in cancer cells hence justifying their use, in many circumstances, in combination with chemotherapy. Stilbenes, flavonoids, carotenoids, and sulfur-containing compounds are among nutraceuticals with prominent anticancer activity. In this chapter, we shed light on the clinical significance of the different nutraceuticals on different cancer types such as gastric, breast, ovarian, and skin cancers.

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Authors and Affiliations

  1. Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

    Shaimaa Fayez, Iriny M. Ayoub, Nada M. Mostafa, Ashaimaa Y. Moussa, Mariam I. Gamal ElDin & Mohamed El-Shazly

  2. Department of Pharmaceutical Biology, German University in Cairo, Cairo, Egypt

    Mohamed El-Shazly

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  1. Shaimaa Fayez
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  2. Iriny M. Ayoub
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  3. Nada M. Mostafa
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  4. Ashaimaa Y. Moussa
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  5. Mariam I. Gamal ElDin
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  6. Mohamed El-Shazly
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Correspondence to Nada M. Mostafa or Mohamed El-Shazly .

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Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

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  1. Department of Internal Medicine, General Hospital Minamiseiko Hospital, Nagoya, Japan

    Takehiko Takayanagi

  2. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA

    Prakash Radhakrishnan

  3. Department of Nutrition and Dietetics, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey

    Ayse Günes-Bayir

  4. Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, Illinois, USA

    Gnanasekar Munirathinam

  5. Dean, Research, Central University of Punjab, Bathinda, Punjab, India

    Anjana Munsi

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Fayez, S., Ayoub, I.M., Mostafa, N.M., Moussa, A.Y., Gamal ElDin, M.I., El-Shazly, M. (2022). Nutraceuticals in Cancer Therapy. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_15-1

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