Abstract
Glioblastoma multiforme (GBM: also called glioblastoma) often occurs in the frontal and temporal lobes of the brain and develops from the glial cells. It is the most devastating and biologically aggressive tumor with challenging treatment strategies, in fact, with limited treatment protocols usually surgery, radiation, and chemotherapy with temozolomide (TMZ). The complex pathology appears to occur due to cellular stress produced by intra-/extracellular stimuli. Furthermore, it has been observed that the stress-induced reactive oxygen/nitrogen species (ROS/RNS) generation increases during GBM progression. Actually, such reactive species distort the activity of the antioxidant system as well as intracellular [Ca2+]i signaling of the glioma cells. In addition, it can induce the posttranslational modifications of cellular proteins and thereby result in the initiation and progression of GBM. Thus, the therapeutic values of the intra-/extracellular agents to modulate the redox status of GBM cells are under investigation. Herein, we summarized the salient features of the GBM and the role of ROS/RNS system in its progression along with the currently known strategies for its treatment.
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Nasrin, T., Chakraborti, S., Shaikh, S. (2022). Reactive Species and ER-Mitochondrial Performance for Glioblastoma Multiforme Treatment Strategy. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_20
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