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Dietary Flavonols and O-Glycosides

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Handbook of Dietary Phytochemicals

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Abstract

Flavonols are the most widespread subgroup of the flavonoids. Quercetin, kaempferol, myricetin, and isorhamnetin are the major dietary flavonol aglycones, which most commonly occur as O-glycosides in dietary sources including fruits, vegetables, tea, and wine. The role of flavonols and O-glycosides in human nutrition has gained increased interest due to their associated health beneficial effects for a number of chronic diseases, including cardiovascular diseases, diabetes, and cancer. However, the potential bioactivity of flavonols and O-glycosides will depend on their bioavailability. Following digestion, flavonol glycosides are cleaved to their aglycones, which may be metabolized in the enterocytes and further in the liver, forming glucuronidated, sulfated, and/or methylated metabolites, or they may be passively permeate the intestinal epithelial barrier. Flavonols that reach the colon may be degraded by the colonic microbiota to different metabolites, which may also contribute to the observed biological effects. In this chapter, the recent findings on the bioavailability, metabolism, bioactivity, and benefits of dietary flavonols and O-glycosides are highlighted. In addition, the recent information on food applications, safety issues, marketed products, and patents are also presented.

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References

  • Abd-Ellah M, Aly H, Mokhlis H, Abdel-Aziz A (2016) Quercetin attenuates di-(2-ethylhexyl) phthalate-induced testicular toxicity in adult rats. Hum Exp Toxicol 35(3):232–243

    Article  CAS  PubMed  Google Scholar 

  • Aherne SA, O’Brien NM (2002) Dietary flavonols: chemistry, food content, and metabolism. Nutrition 18(1):75–81

    Article  CAS  PubMed  Google Scholar 

  • Ahmad A, Kaleem M, Ahmed Z, Shafiq H (2015) Therapeutic potential of flavonoids and their mechanism of action against microbial and viral infections – a review. Food Res Int 77:221–235

    Article  CAS  Google Scholar 

  • Almeida AF, Borge GIA, Piskula M, Tudose A, Tudoreanu L, Valentová K, Williamson G, Santos CN (2018) Bioavailability of quercetin in humans with a focus on interindividual variation. Compr Rev Food Sci Food Saf 17(3):714–731

    Article  CAS  PubMed  Google Scholar 

  • Althunibat OY, Al Hroob AM, Abukhalil MH, Germoush MO, Bin-Jumah M, Mahmoud AM (2019) Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy. Life Sci 221:83

    Article  CAS  PubMed  Google Scholar 

  • Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, Lampen A (2018) Safety aspects of the use of quercetin as a dietary supplement. Mol Nutr Food Res 62(1):1700447

    Article  CAS  Google Scholar 

  • Antunes-Ricardo M, Moreno-García BE, Gutiérrez-Uribe JA, Aráiz-Hernández D, Alvarez MM, Serna-Saldivar SO (2014) Induction of apoptosis in colon cancer cells treated with isorhamnetin glycosides from Opuntia ficus-indica pads. Plant Foods Hum Nutr 69(4):331–336

    Article  CAS  PubMed  Google Scholar 

  • Azuma K, Ippoushi K, Ito H, Higashio H, Terao J (2002) Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. J Agric Food Chem 50(6):1706–1712. https://doi.org/10.1021/jf0112421

    Article  CAS  PubMed  Google Scholar 

  • Azuma K, Ippoushi K, Ito H, Horie H, Terao J (2003) Enhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats. Biosci Biotechnol Biochem 67(12):2548–2555. https://doi.org/10.1271/bbb.67.2548

    Article  CAS  PubMed  Google Scholar 

  • Azzi J, Jraij A, Auezova L, Fourmentin S, Greige-Gerges H (2018) Novel findings for quercetin encapsulation and preservation with cyclodextrins, liposomes, and drug-in-cyclodextrin-in-liposomes. Food Hydrocoll 81:328–340

    Article  CAS  Google Scholar 

  • Bakar SA (2016) Method of inhibiting or treating a dengue virus infection with quercetin. Google Patents

    Google Scholar 

  • Barotto NN, López CB, Eynard AR, Zapico MEF, Valentich MA (1998) Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis. Cancer Lett 129(1):1–6

    Article  CAS  PubMed  Google Scholar 

  • Bazzucchi I, Patrizio F, Ceci R, Duranti G, Sgrò P, Sabatini S, Di Luigi L, Sacchetti M, Felici F (2019) The effects of quercetin supplementation on eccentric exercise-induced muscle damage. Nutrients 11(1):205

    Article  CAS  PubMed Central  Google Scholar 

  • Bei W, Guo J (2017) Preparation and application of flavonol as brain-targeting synergist. Google Patents

    Google Scholar 

  • Ben-Azu B, Aderibigbe AO, Omogbiya IA, Ajayi AM, Owoeye O, Olonode ET, Iwalewa EO (2018) Probable mechanisms involved in the antipsychotic-like activity of morin in mice. Biomed Pharmacother 105:1079–1090

    Article  CAS  PubMed  Google Scholar 

  • Briones-Labarca V, Munoz C, Maureira H (2011) Effect of high hydrostatic pressure on antioxidant capacity, mineral and starch bioaccessibility of a non conventional food: Prosopis chilensis seed. Food Res Int 44(4):875–883

    Article  CAS  Google Scholar 

  • Cao Q, Bao L, Zhong H, Fu H (2018) The method of extracting quercetin and phloretin from the oil tea. CN105924420B, 19.10.2018

    Google Scholar 

  • Cermak R, Wein S, Wolffram S, Langguth P (2009) Effects of the flavonol quercetin on the bioavailability of simvastatin in pigs. Eur J Pharm Sci 38(5):519–524

    Article  CAS  PubMed  Google Scholar 

  • Che J, Liang B, Zhang Y, Wang Y, Tang J, Shi G (2017) Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of autophagy via inhibiting PI3K/Akt/mTOR pathway in human endothelial cells. Cardiovasc Pathol 31:57–62

    Article  CAS  PubMed  Google Scholar 

  • Chen AY, Chen YC (2013) A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem 138(4):2099–2107

    Article  CAS  PubMed  Google Scholar 

  • Chen S, Jiang H, Wu X, Fang J (2016a) Therapeutic effects of quercetin on inflammation, obesity, and type 2 diabetes. Mediat Inflamm 9340637:1–5

    Google Scholar 

  • Chen F, Chen X, Yang D, Che X, Wang J, Li X, Zhang Z, Wang Q, Zheng W, Wang L, Wang X, Wang X (2016b) Isoquercitrin inhibits bladder cancer progression in vivo and in vitro by regulating the PI3K/Akt and PKC signaling pathways. Oncol Rep 36(1):165–172

    Article  CAS  PubMed  Google Scholar 

  • Chen W-F, Wu L, Du Z-R, Chen L, Xu A-L, Chen X-H, Teng J-J, Wong M-S (2017) Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson’s disease: involvement of PI3K/Akt and MEK/ERK signaling pathways. Phytomedicine 25:93–99

    Article  CAS  PubMed  Google Scholar 

  • Chen Y, Dai F, He Y, Chen Q, Xia Q, Cheng G, Lu Y, Zhang Q (2018) Beneficial effects of hyperoside on bone metabolism in ovariectomized mice. Biomed Pharmacother 107:1175–1182

    Article  CAS  PubMed  Google Scholar 

  • Choi JS, Choi BC, Choi KE (2004) Effect of quercetin on the pharmacokinetics of oral cyclosporine. Am J Health Syst Pharm 61(22):2406–2409

    Article  CAS  PubMed  Google Scholar 

  • Choudhury R, Srai SK, Debnam E, Rice-Evans CA (1999) Urinary excretion of hydroxycinnamates and flavonoids after oral and intravenous administration. Free Radic Biol Med 27(3–4):278–286

    Article  CAS  PubMed  Google Scholar 

  • Crozier A, Jaganath IB, Clifford MN (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26(8):1001–1043

    Article  CAS  PubMed  Google Scholar 

  • Dai Y, Zhang H, Zhang J, Yan M (2018) Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway. Chem Biol Interact 284:32–40

    Article  CAS  PubMed  Google Scholar 

  • Dajas F, Tedesco A, Blasina F, Vaamonde L, Marcela D (2016) Nanosomal preparation of the complex formed by quercetin (or another flavonol, flavone or a derivative thereof) and 2-hydroxypropyl-beta-cyclodextrin for intravenous use in cerebral pathological conditions. Google Patents

    Google Scholar 

  • Dang Y, Lin G, Xie Y, Duan J, Ma P, Li G, Ji G (2014) Quantitative determination of myricetin in rat plasma by ultra performance liquid chromatography tandem mass spectrometry and its absolute bioavailability. Drug Res 64(10):516–522

    CAS  Google Scholar 

  • Das J, Singh R, Sharma D (2017) Antiepileptic effect of fisetin in iron-induced experimental model of traumatic epilepsy in rats in the light of electrophysiological, biochemical, and behavioral observations. Nutr Neurosci 20(4):255–264

    Article  CAS  PubMed  Google Scholar 

  • Day AJ, Mellon F, Barron D, Sarrazin G, Morgan MR, Williamson G (2001) Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin. Free Radic Res 35(6):941–952

    Article  CAS  PubMed  Google Scholar 

  • Devi KP, Malar DS, Nabavi SF, Sureda A, Xiao J, Nabavi SM, Daglia M (2015) Kaempferol and inflammation: from chemistry to medicine. Pharmacol Res 99:1–10

    Article  CAS  PubMed  Google Scholar 

  • Domitrović R, Rashed K, Cvijanović O, Vladimir-Knežević S, Škoda M, Višnić A (2015) Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. Chem Biol Interact 230:21–29

    Article  PubMed  CAS  Google Scholar 

  • Dos Reis LCR, De Oliveira VR, Hagen MEK, Jablonski A, Flôres SH, de Oliveira Rios A (2015) Effect of cooking on the concentration of bioactive compounds in broccoli (Brassica oleracea var. avenger) and cauliflower (Brassica oleracea var. Alphina F1) grown in an organic system. Food Chem 172:770–777

    Article  CAS  PubMed  Google Scholar 

  • Duan KM, Wang SY, Ouyang W, Mao YM, Yang LJ (2012) Effect of quercetin on CYP3A activity in Chinese healthy participants. J Clin Pharmacol 52(6):940–946

    Article  CAS  PubMed  Google Scholar 

  • Dunnick JK, Hailey JR (1992) Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Toxicol Sci 19(3):423–431

    Article  CAS  Google Scholar 

  • Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T (2007) Quercetin reduces blood pressure in hypertensive subjects. J Nutr 137(11):2405–2411

    Article  CAS  PubMed  Google Scholar 

  • Elgorashi E, Van Heerden F, Van Staden J (2008) Kaempferol, a mutagenic flavonol from Helichrysum simillimum. Hum Exp Toxicol 27(11):845–849

    Article  CAS  PubMed  Google Scholar 

  • Elkholy R, Balaha M, El-Anwar N, Kandeel S, Hedya S, Abd-El Rahman M-N (2019) Fisetin and telmisartan each alone or in low-dose combination alleviate OVA-induced food allergy in mice. Pharmacol Rep 71(2):330–337

    Article  CAS  PubMed  Google Scholar 

  • Erlund I, Alfthan G, Mäenpää J, Aro A (2001) Tea and coronary heart disease: the flavonoid quercetin is more bioavailable from rutin in women than in men. Arch Intern Med 161(15):1919–1920

    Article  CAS  PubMed  Google Scholar 

  • Escarpa A, Gonzalez M (2001) An overview of analytical chemistry of phenolic compounds in foods. Crit Rev Anal Chem 31(2):57–139

    Article  CAS  Google Scholar 

  • Fang Z, Bhandari B (2010) Encapsulation of polyphenols–a review. Trends Food Sci Technol 21(10):510–523

    Article  CAS  Google Scholar 

  • Fang L, Xu W, Kong D (2019) Icariin inhibits cell proliferation, migration and invasion by down-regulation of microRNA-625-3p in thyroid cancer cells. Biomed Pharmacother 109:2456–2463

    Article  CAS  PubMed  Google Scholar 

  • Farsad-Naeimi A, Alizadeh M, Esfahani A, Aminabad ED (2018) Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients. Food Funct 9(4):2025–2031

    Article  CAS  PubMed  Google Scholar 

  • Feng G, Jiang Z-y, Sun B, Fu J, Li T-z (2016) Fisetin alleviates lipopolysaccharide-induced acute lung injury via TLR4-mediated NF-κB signaling pathway in rats. Inflammation 39(1):148–157

    Article  CAS  PubMed  Google Scholar 

  • Ferri P, Angelino D, Gennari L, Benedetti S, Ambrogini P, Del Grande P, Ninfali P (2015) Enhancement of flavonoid ability to cross the blood–brain barrier of rats by co-administration with α-tocopherol. Food Funct 6(2):394–400. https://doi.org/10.1039/C4FO00817K

    Article  CAS  PubMed  Google Scholar 

  • Galati G, O’Brien PJ (2004) Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 37(3):287–303

    Article  CAS  PubMed  Google Scholar 

  • Ganio MS, Armstrong LE, Johnson EC, Klau JF, Ballard KD, Michniak-Kohn B, Kaushik D, Maresh CM (2010) Effect of quercetin supplementation on maximal oxygen uptake in men and women. J Sports Sci 28(2):201–208

    Article  PubMed  Google Scholar 

  • Garg S, Malhotra RK, Khan SI, Sarkar S, Susrutha P, Singh V, Goyal S, Nag TC, Ray R, Bhatia J (2019) Fisetin attenuates isoproterenol-induced cardiac ischemic injury in vivo by suppressing RAGE/NF-κB mediated oxidative stress, apoptosis and inflammation. Phytomedicine 56:147–155

    Article  CAS  PubMed  Google Scholar 

  • Gómez-Florit M, Monjo M, Ramis JM (2015) Quercitrin for periodontal regeneration: effects on human gingival fibroblasts and mesenchymal stem cells. Sci Rep 5:16593

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gong M-j, Han B, Wang S-m, Liang S-w, Zou Z-j (2016) Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats. J Pharm Biomed Anal 123:63–73

    Article  CAS  PubMed  Google Scholar 

  • Gormaz JG, Quintremil S, Rodrigo R (2015) Cardiovascular disease: a target for the pharmacological effects of quercetin. Curr Top Med Chem 15(17):1735–1742

    Article  CAS  PubMed  Google Scholar 

  • Gugler R, Leschik M, Dengler HJ (1975) Disposition of quercetin in man after single oral and intravenous doses. Eur J Clin Pharmacol 9(2–3):229–234

    Article  CAS  PubMed  Google Scholar 

  • Guo Y, Mah E, Davis CG, Jalili T, Ferruzzi MG, Chun OK, Bruno RS (2013) Dietary fat increases quercetin bioavailability in overweight adults. Mol Nutr Food Res 57(5):896–905. https://doi.org/10.1002/mnfr.201200619

    Article  CAS  PubMed  Google Scholar 

  • Haleagrahara N, Miranda-Hernandez S, Alim MA, Hayes L, Bird G, Ketheesan N (2017) Therapeutic effect of quercetin in collagen-induced arthritis. Biomed Pharmacother 90:38–46

    Article  CAS  PubMed  Google Scholar 

  • Hao J, Guo B, Yu S, Zhang W, Zhang D, Wang J, Wang Y (2017) Encapsulation of the flavonoid quercetin with chitosan-coated nano-liposomes. LWT Food Sci Technol 85:37–44

    Article  CAS  Google Scholar 

  • Hobbs CA, Swartz C, Maronpot R, Davis J, Recio L, Koyanagi M, Hayashi S-m (2015) Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin. Food Chem Toxicol 83:283–292

    Article  CAS  PubMed  Google Scholar 

  • Hollman PC (2004) Absorption, bioavailability, and metabolism of flavonoids. Pharm Biol 42(sup1):74–83

    Article  CAS  Google Scholar 

  • Hollman PCH, Arts ICW (2000) Flavonols, flavones and flavanols–nature, occurrence and dietary burden. J Sci Food Agric 80(7):1081–1093

    Article  CAS  Google Scholar 

  • Hollman PC, Van Het Hof KH, Tijburg LB, Katan MB (2001) Addition of milk does not affect the absorption of flavonols from tea in man. Free Radic Res 34(3):297–300

    Article  CAS  PubMed  Google Scholar 

  • Hollman PC, Bijsman MN, van Gameren Y, Cnossen EP, de Vries JH, Katan MB (1999) The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radic Res 31(6):569–573

    Article  CAS  PubMed  Google Scholar 

  • Hsiu S-L, Hou Y-C, Wang Y-H, Tsao C-W, Su S-F, Chao P-DL (2002) Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats. Life Sci 72(3):227–235

    Article  CAS  PubMed  Google Scholar 

  • Huang H, Chen AY, Rojanasakul Y, Ye X, Rankin GO, Chen YC (2015) Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis. J Funct Foods 15:464–475

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ito N, Hagiwara A, Tamano S, Kagawa M, Shibata MA, Kurata Y, Fukushima S (1989) Lack of carcinogenicity of quercetin in F344/DuCrj rats. Jpn J Cancer Res 80(4):317–325

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jacob S, Sumathi T (2019) Extenuation of in utero toxic effects of MeHg in the developing neurons by Fisetin via modulating the expression of synaptic transmission and plasticity regulators in hippocampus of the rat offspring. Chem Biol Interact 305:3

    Article  CAS  PubMed  Google Scholar 

  • Jacob S, Thangarajan S (2017) Effect of gestational intake of Fisetin (3, 3′, 4′, 7-tetrahydroxyflavone) on developmental methyl mercury neurotoxicity in F1 generation rats. Biol Trace Elem Res 177(2):297–315

    Article  CAS  PubMed  Google Scholar 

  • Jakobek L, Barron AR (2016) Ancient apple varieties from Croatia as a source of bioactive polyphenolic compounds. J Food Compos Anal 45:9–15

    Article  CAS  Google Scholar 

  • Janeesh PA, Sasikala V, Dhanya CR, Abraham A (2014) Robinin modulates TLR/NF-κB signaling pathway in oxidized LDL induced human peripheral blood mononuclear cells. Int Immunopharmacol 18(1):191–197

    Article  CAS  PubMed  Google Scholar 

  • Javadi F, Eghtesadi S, Ahmadzadeh A, Aryaeian N, Zabihiyeganeh M, Foroushani AR, Jazayeri S (2014) The effect of quercetin on plasma oxidative status, C-reactive protein and blood pressure in women with rheumatoid arthritis. Int J Prev Med 5(3):293

    PubMed  PubMed Central  Google Scholar 

  • Jayachandran M, Wu Z, Ganesan K, Khalid S, Chung S, Xu B (2019) Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats. Chem Biol Interact 303:62

    Article  CAS  PubMed  Google Scholar 

  • Jo I-J, Bae G-S, Choi SB, Kim D-G, Shin J-Y, Seo S-H, Choi M-O, Kim T-H, Song H-J, Park S-J (2014) Fisetin attenuates cerulein-induced acute pancreatitis through down regulation of JNK and NF-κB signaling pathways. Eur J Pharmacol 737:149–158

    Article  CAS  PubMed  Google Scholar 

  • Jung YY, Lee JH, Nam D, Narula AS, Namjoshi OA, Blough BE et al (2018) Anti-myeloma effects of icariin are mediated through the attenuation of JAK/STAT3-dependent signaling cascade. Front Pharmacol 9:531

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kamiloglu S, Toydemir G, Boyacioglu D, Beekwilder J, Hall RD, Capanoglu E (2016) A review on the effect of drying on antioxidant potential of fruits and vegetables. Crit Rev Food Sci Nutr S110–S129. https://doi.org/10.1080/10408398.2015.1045969

  • Kashyap D, Mittal S, Sak K, Singhal P, Tuli HS (2016) Molecular mechanisms of action of quercetin in cancer: recent advances. Tumor Biol 37(10):12927–12939

    Article  CAS  Google Scholar 

  • Kim YJ (2016) Rhamnazin inhibits LPS-induced inflammation and ROS/RNS in raw macrophages. J Nutr Health 49(5):288–294

    Article  CAS  Google Scholar 

  • Kim K-A, Park P-W, Park J-Y (2009) Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers. Eur J Clin Pharmacol 65(6):609–614

    Article  CAS  PubMed  Google Scholar 

  • Kim ME, Ha TK, Yoon JH, Lee JS (2014) Myricetin induces cell death of human colon cancer cells via BAX/BCL2-dependent pathway. Anticancer Res 34(2):701–706

    CAS  PubMed  Google Scholar 

  • Kim G-D, Lee SE, Park YS, Shin D-H, Park GG, Park C-S (2014a) Immunosuppressive effects of fisetin against dinitrofluorobenzene-induced atopic dermatitis-like symptoms in NC/Nga mice. Food Chem Toxicol 66:341–349

    Article  CAS  PubMed  Google Scholar 

  • Kim JK, Seo Y-K, Park S, Park S-A, Lim S, Lee S, Seo JK, Choi U-K, Ryu SH, Suh P-G (2014b) Spiraeoside inhibits mast cells activation and IgE-mediated allergic responses by suppressing phospholipase C-γ-mediated signaling. Biochem Cell Biol 93(3):227–235

    Article  PubMed  CAS  Google Scholar 

  • Kim K-T, Choi B-H, Jung H-Y, Shin J-C, Oh S-T, Kang M-S (2015) Composition comprising myricetin as active ingredient for enhancing exercise performance or fatigue recovery. Google Patents

    Google Scholar 

  • Kim SY, Young J, Kwon DJ, Kim YH (2018) A pharmaceutical composition for preventing or treating liver disease comprising Quercetin-3-O-B-D-xylopyranoside. South Korea Patent KR101840950B1, 21.03.2018

    Google Scholar 

  • Koneru M, Sahu BD, Kumar JM, Kuncha M, Kadari A, Kilari EK, Sistla R (2016) Fisetin protects liver from binge alcohol-induced toxicity by mechanisms including inhibition of matrix metalloproteinases (MMPs) and oxidative stress. J Funct Foods 22:588–601

    Article  CAS  Google Scholar 

  • Krolevets AA (2016) Method of producing nanocapsules of quercetin and dihydroquercetin. Russia Patent RU2603458C1, 27.11.2016

    Google Scholar 

  • Lai I, Lai A (2017) Method for alleviating radiation injury with isorhamnetin-3-O-β-d-glucoside. Google Patents

    Google Scholar 

  • Lee SS (2018) Quercetin containing breast cancer treatment composition. South Korea Patent KR101851470B1, 11.06.2018

    Google Scholar 

  • Lee S, Ro H, In HJ, Choi JH, Kim MO, Lee J et al (2018) Fisetin inhibits TNF-α/NF-κB-induced IL-8 expression by targeting PKCδ in human airway epithelial cells. Cytokine 108:247–254

    Article  CAS  PubMed  Google Scholar 

  • Lemos C, Peters GJ, Jansen G, Martel F, Calhau C (2007) Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds. Eur J Nutr 46(6):329–336

    Article  CAS  PubMed  Google Scholar 

  • Leonard E, Yan Y, Koffas MA (2006) Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli. Metab Eng 8(2):172–181

    Article  CAS  PubMed  Google Scholar 

  • Lesser S, Cermak R, Wolffram S (2004) Bioavailability of quercetin in pigs is influenced by the dietary fat content. J Nutr 134(6):1508–1511. https://doi.org/10.1093/jn/134.6.1508

    Article  CAS  PubMed  Google Scholar 

  • Lesser S, Cermak R, Wolffram S (2006) The fatty acid pattern of dietary fat influences the oral bioavailability of the flavonol quercetin in pigs. Br J Nutr 96(6):1047–1052. https://doi.org/10.1017/BJN20061953

    Article  CAS  PubMed  Google Scholar 

  • Li L, Qin J, Fu T, Shen J (2019) Fisetin rescues retinal functions by suppressing inflammatory response in a DBA/2J mouse model of glaucoma. Doc Ophthalmol 138(2):125–135

    Article  PubMed  Google Scholar 

  • Liang KS, Yin CB, Peng LJ, Zhang JL, Guo X, Liang SY et al (2017) Effect of troxerutin and cerebroprotein hydrolysate injection for the treatment of acute cerebral infarction: a multi-center randomized, single-blind and placebo-controlled study. Int J Clin Exp Med 10(7):10959–10964

    Google Scholar 

  • Liao W, Chen L, Ma X, Jiao R, Li X, Wang Y (2016) Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells. Eur J Med Chem 114:24–32

    Article  CAS  PubMed  Google Scholar 

  • Lin K-H, Shibu MA, Peramaiyan R, Chen Y-F, Shen C-Y, Hsieh Y-L, Chen R-J, Viswanadha VP, Kuo W-W, Huang C-Y (2019) Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats. J Funct Foods 52:212–218

    Article  CAS  Google Scholar 

  • Lines TC (2015) Method for treating cancer with a combination of quercetin and a chemotherapy agent. Google Patents

    Google Scholar 

  • Lines TC (2016) Method for treating metabolic syndrome and diabetes using quercetin and bauhinia forficata extract. Google Patents

    Google Scholar 

  • Lines TC (2017) Method for treating zika virus infection with quercetin-containing compositions. Google Patents

    Google Scholar 

  • Liu C, Ma M, Zhang J, Gui S, Zhang X, Xue S (2017) Galangin inhibits human osteosarcoma cells growth by inducing transforming growth factor-β1-dependent osteogenic differentiation. Biomed Pharmacother 89:1415–1421

    Article  CAS  PubMed  Google Scholar 

  • Lu NT, Crespi CM, Liu NM, Vu JQ, Ahmadieh Y, Wu S, Lin S, McClune A, Durazo F, Saab S (2016) A phase I dose escalation study demonstrates quercetin safety and explores potential for bioflavonoid antivirals in patients with chronic hepatitis C. Phytother Res 30(1):160–168

    Article  CAS  PubMed  Google Scholar 

  • Ma Z, Hung Nguyen T, Hoa Huynh T, Tien Do P, Huynh H (2004) Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation. J Endocrinol 181(3):493–508

    Article  CAS  PubMed  Google Scholar 

  • Ma J-Q, Li Z, Xie W-R, Liu C-M, Liu S-S (2015a) Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway. Int Immunopharmacol 28(1):531–539

    Article  CAS  PubMed  Google Scholar 

  • Ma Z, Piao T, Wang Y, Liu J (2015b) Astragalin inhibits IL-1β-induced inflammatory mediators production in human osteoarthritis chondrocyte by inhibiting NF-κB and MAPK activation. Int Immunopharmacol 25(1):83–87

    Article  CAS  PubMed  Google Scholar 

  • Manach C, Morand C, Texier O, Favier ML, Agullo G, Demigné C, Régérat F, Rémésy C (1995) Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin. J Nutr 125(7):1911–1922

    Article  CAS  PubMed  Google Scholar 

  • Marín L, Miguélez EM, Villar CJ, Lombó F (2015) Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. BioMed Res Int 2015:905215

    Google Scholar 

  • Matsumoto M, Matsukawa N, Chiji H, Hara H (2007) Difructose anhydride III promotes absorption of the soluble flavonoid αG-rutin in rats. J Agric Food Chem 55(10):4202–4208

    Article  CAS  PubMed  Google Scholar 

  • Matsukawa Y, Nishino H, Yoshida M, Sugihara H, Katsura K, Takamatsu T, Okuzumi J, Matsumoto K, Sato-Nishimori F, Sakai T (2002) Quercetin enhances tumorigenicity induced by N-ethyl-N′-nitro-N-nitrosoguanidine in the duodenum of mice. Environ Health Prev Med 6(4):235–239

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mbikay M, Sirois F, Chretien M, Mayne J (2015) Quercetin-3-glucoside and uses thereof. Google Patents

    Google Scholar 

  • Menezes R, Rodriguez-Mateos A, Kaltsatou A, González-Sarrías A, Greyling A, Giannaki C, Andres-Lacueva C, Milenkovic D, Gibney E, Dumont J (2017) Impact of flavonols on cardiometabolic biomarkers: a meta-analysis of randomized controlled human trials to explore the role of inter-individual variability. Nutrients 9(2):117

    Article  PubMed Central  CAS  Google Scholar 

  • Mo JS, Choi D, Han YR, Kim N, Jeong HS (2019) Morin has protective potential against ER stress induced apoptosis in renal proximal tubular HK-2 cells. Biomed Pharmacother 112:108659

    Article  CAS  PubMed  Google Scholar 

  • Morand C, Manach C, Crespy V, Remesy C (2000) Respective bioavailability of quercetin aglycone and its glycosides in a rat model. Biofactors 12(1–4):169–174

    Google Scholar 

  • Nath LR, Gorantla JN, Joseph SM, Antony J, Thankachan S, Menon DB et al (2015) Kaempferide, the most active among the four flavonoids isolated and characterized from Chromolaena odorata, induces apoptosis in cervical cancer cells while being pharmacologically safe. RSC Adv 5(122):100912–100922

    Article  CAS  Google Scholar 

  • Nayak B, Liu RH, Tang J (2015) Effect of processing on phenolic antioxidants of fruits, vegetables, and grains – a review. Crit Rev Food Sci Nutr 55(7):887–918

    Article  CAS  PubMed  Google Scholar 

  • Nguyen M, Staubach P, Wolffram S, Langguth P (2014) Effect of single-dose and short-term administration of quercetin on the pharmacokinetics of talinolol in humans–implications for the evaluation of transporter-mediated flavonoid–drug interactions. Eur J Pharm Sci 61:54–60

    Article  CAS  PubMed  Google Scholar 

  • Nguyen MA, Staubach P, Wolffram S, Langguth P (2015) The influence of single-dose and short-term administration of quercetin on the pharmacokinetics of midazolam in humans. J Pharm Sci 104(9):3199–3207

    Article  CAS  PubMed  Google Scholar 

  • Orrego-Lagarón N, Martínez-Huélamo M, Quifer-Rada P, Lamuela-Raventos RM, Escribano-Ferrer E (2016) Absorption and disposition of naringenin and quercetin after simultaneous administration via intestinal perfusion in mice. Food Funct 7(9):3880–3889. https://doi.org/10.1039/c6fo00633g

    Article  PubMed  Google Scholar 

  • Otsuka Y, Egawa K, Kanzaki N (2017) Muscle atrophy inhibitor containing quercetin glycoside. Google Patents

    Google Scholar 

  • Ożarowski M, Mikołajczak PŁ, Kujawski R, Wielgus K, Klejewski A, Wolski H, Seremak-Mrozikiewicz A (2018) Pharmacological effect of quercetin in hypertension and its potential application in pregnancy-induced hypertension: review of in vitro, in vivo, and clinical studies. Evid Based Complement Alternat Med 7421489:1–19

    Google Scholar 

  • Park YI, Lee S-s, Choi JW, Song JK (2017) Composition comprising Quercetin-3-O-xyloside having immunostimulating activity. South Korea Patent KR20170043363A, 12.06.2017

    Google Scholar 

  • Pereira MA, Grubbs CJ, Barnes LH, Li H, Olson GR, Eto I, Juliana M, Whitaker LM, Kelloff GJ, Steele VE (1996) Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7, 12-dimethylbenz [a] anthracene-induced mammary cancer in rats. Carcinogenesis 17(6):1305–1311

    Article  CAS  PubMed  Google Scholar 

  • Phenol-explorer database. www.phenol-explorer.eu

  • Program NT (1992) Toxicology and carcinogenesis studies of quercetin (CAS no. 117-39-5) in F344 rats (feed studies). Natl Toxicol Program Tech Rep Ser 409:1

    Google Scholar 

  • Reinboth M, Wolffram S, Abraham G, Ungemach FR, Cermak R (2010) Oral bioavailability of quercetin from different quercetin glycosides in dogs. Br J Nutr 104(2):198–203

    Article  CAS  PubMed  Google Scholar 

  • Rezvan N, Moini A, Janani L, Mohammad K, Saedisomeolia A, Nourbakhsh M, Gorgani-Firuzjaee S, Mazaherioun M, Hosseinzadeh-Attar MJ (2017) Effects of quercetin on adiponectin-mediated insulin sensitivity in polycystic ovary syndrome: a randomized placebo-controlled double-blind clinical trial. Horm Metab Res 49(02):115–121

    CAS  PubMed  Google Scholar 

  • Rickman JC, Barrett DM, Bruhn CM (2007) Nutritional comparison of fresh, frozen and canned fruits and vegetables. Part 1. Vitamins C and B and phenolic compounds. J Sci Food Agric 87(6):930–944

    Article  CAS  Google Scholar 

  • Rothwell JA, Medina-Remón A, Pérez-Jiménez J, Neveu V, Knaze V, Slimani N, Scalbert A (2015) Effects of food processing on polyphenol contents: a systematic analysis using Phenol-Explorer data. Mol Nutr Food Res 59(1):160–170

    Article  CAS  PubMed  Google Scholar 

  • Serban MC, Sahebkar A, Zanchetti A, Mikhailidis DP, Howard G, Antal D et al (2016) Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc 5(7):e002713

    Article  PubMed  PubMed Central  Google Scholar 

  • Serra A, Macià A, Romero M-P, Reguant J, Ortega N, Motilva M-J (2012) Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids. Food Chem 130(2):383–393

    Article  CAS  Google Scholar 

  • Shi Y, Williamson G (2016) Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial. Br J Nutr 115(5):800–806

    Article  CAS  PubMed  Google Scholar 

  • Shi W, Song X, Cui F, Luo Z, Zhang K, Xu C (2018a)A method of extracting kaempferol and quercetin from the witch hazel. China Patent CN106187972B, 06.02.2018

    Google Scholar 

  • Shi Y-S, Li C-B, Li X-Y, Wu J, Li Y, Fu X, Zhang Y, Hu W-Z (2018b) Fisetin attenuates metabolic dysfunction in mice challenged with a high-fructose diet. J Agric Food Chem 66(31):8291–8298

    Article  CAS  PubMed  Google Scholar 

  • Shoskes DA, Zeitlin SI, Shahed A, Rajfer J (1999) Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 54(6):960–963

    Article  CAS  PubMed  Google Scholar 

  • Silberberg M, Morand C, Manach C, Scalbert A, Remesy C (2005) Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism. Life Sci 77(25):3156–3167. https://doi.org/10.1016/j.lfs.2005.03.033

    Article  CAS  PubMed  Google Scholar 

  • Singh H, Gallier S (2014) Processing of food structures in the gastrointestinal tract and physiological responses. In: Food structures, digestion and health. Elsevier: USA, pp 51–81

    Google Scholar 

  • Singh B, Mense SM, Bhat NK, Putty S, Guthiel WA, Remotti F, Bhat HK (2010) Dietary quercetin exacerbates the development of estrogen-induced breast tumors in female ACI rats. Toxicol Appl Pharmacol 247(2):83–90

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Singh S, Garg G, Singh AK, Bissoyi A, Rizvi SI (2019) Fisetin, a potential caloric restriction mimetic, attenuates senescence biomarkers in rat erythrocytes. Biochem Cell Biol 97:480

    Article  CAS  PubMed  Google Scholar 

  • Survay NS, Upadhyaya CP, Kumar B, Young KE, Yoon DY, Park SW (2011) New genera of flavonols and flavonol derivatives as therapeutic molecules. J Korean Soc Appl Biol Chem 54(1):1–18

    Article  CAS  Google Scholar 

  • Tamura M, Nakagawa H, Tsushida T, Hirayama K, Itoh K (2007) Effect of pectin enhancement on plasma quercetin and fecal flora in rutin-supplemented mice. J Food Sci 72(9):S648–S651. https://doi.org/10.1111/j.1750-3841.2007.00557.x

    Article  CAS  PubMed  Google Scholar 

  • Terao J (2009) Flavonols: metabolism, bioavailability, and health impacts. In: Plant polyphenolics and human health. Wiley: USA, pp 185–196

    Google Scholar 

  • Thomas NS, George K, Arivalagan S, Mani V, Siddique AI, Namasivayam N (2017) The in vivo antineoplastic and therapeutic efficacy of troxerutin on rat preneoplastic liver: biochemical, histological and cellular aspects. Eur J Nutr 56(7):2353–2366

    Article  CAS  PubMed  Google Scholar 

  • Valentich M, Eynard A, Barotto N, Diaz M, Bongiovanni G (2006) Effect of the co-administration of phenobarbital, quercetin and mancozeb on nitrosomethylurea-induced pancreatic tumors in rats. Food Chem Toxicol 44(12):2101–2105

    Article  CAS  PubMed  Google Scholar 

  • Wang J, Huang S (2018) Fisetin inhibits the growth and migration in the A549 human lung cancer cell line via the ERK1/2 pathway. Exp Ther Med 15(3):2667–2673

    CAS  PubMed  Google Scholar 

  • Wang HX, Tang C (2017) Galangin suppresses human laryngeal carcinoma via modulation of caspase-3 and AKT signaling pathways. Oncol Rep 38(2):703–714

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang S, Duan K, Li Y, Mei Y, Sheng H, Liu H, Mei X, Ouyang W, Zhou H, Liu Z (2013) Effect of quercetin on P-glycoprotein transport ability in Chinese healthy subjects. Eur J Clin Nutr 67(4):390

    Article  CAS  PubMed  Google Scholar 

  • Wang X, Bao L, Zhong H, Fu H (2015) Quercetin nanoparticle and preparation method thereof. China Patent CN105106117A, 02.12.2015

    Google Scholar 

  • Wang Y, Wang B, Lu J, Shi H, Gong S, Wang Y, Hamdy RC, Chua BH, Yang L, Xu X (2017) Fisetin provides antidepressant effects by activating the tropomyosin receptor kinase B signal pathway in mice. J Neurochem 143(5):561–568

    Article  CAS  PubMed  Google Scholar 

  • Wu LX, Guo CX, Chen WQ, Yu J, Qu Q, Chen Y, Tan ZR, Wang G, Fan L, Li Q (2012) Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment. Br J Clin Pharmacol 73(5):750–757

    Article  CAS  PubMed  Google Scholar 

  • Wu S, Yue Y, Peng A, Zhang L, Xiang J, Cao X et al (2016) Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats. Food Funct 7(6):2624–2634

    Article  CAS  PubMed  Google Scholar 

  • Xiao J (2017) Dietary flavonoid aglycones and their glycosides: which show better biological significance? Crit Rev Food Sci Nutr 57(9):1874–1905

    CAS  PubMed  Google Scholar 

  • Xiao H, Wignall N, Brown ES (2016) An open-label pilot study of icariin for co-morbid bipolar and alcohol use disorder. Am J Drug Alcohol Abuse 42(2):162–167

    Article  PubMed  Google Scholar 

  • Xie W, Wang M, Chen C, Zhang X, Melzig MF (2016) Hepatoprotective effect of isoquercitrin against acetaminophen-induced liver injury. Life Sci 152:180–189

    Article  CAS  PubMed  Google Scholar 

  • Xie C, Liu L, Wang Z, Xie H, Feng Y, Suo J et al (2018) Icariin improves Sepsis-induced mortality and acute kidney injury. Pharmacology 102(3–4):196–205

    Article  CAS  PubMed  Google Scholar 

  • Xiong D, Deng Y, Huang B, Yin C, Liu B, Shi J, Gong Q (2016) Icariin attenuates cerebral ischemia–reperfusion injury through inhibition of inflammatory response mediated by NF-κB, PPARα and PPARγ in rats. Int Immunopharmacol 30:157–162

    Article  CAS  PubMed  Google Scholar 

  • Xu FQ, Feng YY, Yan BL (2014) Detection of tamarixetin and kaempferide in different tissues by high-performance liquid chromatography in tamarixetin and kaempferide treated rats. J Med Plants Res 8(18):664–668

    Google Scholar 

  • Youns M, Hegazy WAH (2017) The natural flavonoid fisetin inhibits cellular proliferation of hepatic, colorectal, and pancreatic cancer cells through modulation of multiple signaling pathways. PLoS One 12(1):e0169335

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yu C-P, Wu P-P, Hou Y-C, Lin S-P, Tsai S-Y, Chen C-T, Chao P-DL (2011) Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4. J Agric Food Chem 59(9):4644–4648

    Article  CAS  PubMed  Google Scholar 

  • Zhang T (2016) Method for extracting rutin from Japanese pagoda tree flower buds and preparing quercetin. China Patent CN105541776A, 04.05.2016

    Google Scholar 

  • Zhang Y, Shan S, Wang J, Cheng X, Yi B, Zhou J, Li Q (2016) Galangin inhibits hypertrophic scar formation via ALK5/Smad2/3 signaling pathway. Mol Cell Biochem 413(1–2):109–118

    CAS  PubMed  Google Scholar 

  • Zhang Z, Wang X, Zheng G, Shan Q, Lu J, Fan S, Sui J (2017) Troxerutin attenuates enhancement of hepatic gluconeogenesis by inhibiting NOD activation-mediated inflammation in high-fat diet-treated mice. Int J Mol Sci 18(1):31

    Article  CAS  Google Scholar 

  • Zhang L, Zhang ST, Yin YC, Xing S, Li WN, Fu XQ (2018) Hypoglycemic effect and mechanism of isoquercitrin as an inhibitor of dipeptidyl peptidase-4 in type 2 diabetic mice. RSC Adv 8(27):14967–14974

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang L, Xiong Q, Yang H, Wang H, Yang C (2019) A kind of novel quercetin nano preparation and preparation method thereof. China Patent CN109172543A, 11.01.2019

    Google Scholar 

  • Zhou M, Ren H, Han J, Wang W, Zheng Q, Wang D (2015) Protective effects of kaempferol against myocardial ischemia/reperfusion injury in isolated rat heart via antioxidant activity and inhibition of glycogen synthase kinase-3β. Oxidative Med Cell Longev 2015:481405

    Article  Google Scholar 

  • Zhou YD, Hou JG, Yang G, Jiang S, Chen C, Wang Z et al (2019) Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway. Biomed Pharmacother 109:2309–2317

    Article  CAS  PubMed  Google Scholar 

  • Zhu B, Liehr JG (1994) Quercetin increases the severity of estradiol-induced tumorigenesis in hamster kidney. Toxicol Appl Pharmacol 125(1):149–158

    Article  CAS  PubMed  Google Scholar 

  • Zhu Y, Rao Q, Zhang X, Zhou X (2018) Galangin induced antitumor effects in human kidney tumor cells mediated via mitochondrial mediated apoptosis, inhibition of cell migration and invasion and targeting PI3K/AKT/mTOR signalling pathway. J BUON 23:795–799

    PubMed  Google Scholar 

  • Zou WW, Xu SP (2018) Galangin inhibits the cell progression and induces cell apoptosis through activating PTEN and Caspase-3 pathways in retinoblastoma. Biomed Pharmacother 97:851–863

    Article  CAS  PubMed  Google Scholar 

  • Zou L, Chen S, Li L, Wu T (2017) The protective effect of hyperoside on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2. Exp Toxicol Pathol 69(7):451–460

    Article  CAS  PubMed  Google Scholar 

  • Zou W, Liu W, Yang B, Wu L, Yang J, Zou T, Liu F, Xia L, Zhang D (2015) Quercetin protects against perfluorooctanoic acid-induced liver injury by attenuating oxidative stress and inflammatory response in mice. Int Immunopharmacol 28(1):129–135

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. R&D Department, Mevsim Gida Sanayi ve Soguk Depo Ticaret A.S. (MVSM Foods), Kestel, Bursa, Turkey

    Senem Kamiloglu

  2. Department of Food Engineering, Istanbul Sabahattin Zaim University, Halkali, Istanbul, Turkey

    Merve Tomas

  3. Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul, Turkey

    Esra Capanoglu

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  1. Senem Kamiloglu
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  2. Merve Tomas
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  3. Esra Capanoglu
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  1. Faculty of Food Science and Technology University of Vigo, Vigo, Spain

    Jianbo Xiao

  2. Liverpool John Moores University, Liverpool, UK

    Satyajit D. Sarker

  3. Institute of PharmacognosyTokushima Bunri University, Tokushima, Japan

    Yoshinori Asakawa

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Kamiloglu, S., Tomas, M., Capanoglu, E. (2021). Dietary Flavonols and O-Glycosides. In: Xiao, J., Sarker, S.D., Asakawa, Y. (eds) Handbook of Dietary Phytochemicals. Springer, Singapore. https://doi.org/10.1007/978-981-15-4148-3_4

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