Introduction
The introduction of fluorine into an organic molecule is a reaction of great interest in both industrial and academic researches [353,354,355,356,5]. Despite the significant achievements made in the synthesis of aryl fluorides, there are only a limited number of examples of alkyl fluoride synthesis. These include nucleophilic [6] or electrophilic [7] substitution reactions or radical fluorination [8, 9]. Among them, the nucleophilic substitution of alkyl sulfonates and halides with fluoride ions appeared as a powerful strategy to generate alkyl fluorides [10, 11], but remains challenging. The difficulty arises from the weak nucleophilicity in protic solvent or the low solubility in aprotic solvents of fluoride ions (such as KF or CsF). To overcome these difficulties, a variety of metal fluorides such as KF/18-crown-6 [12], “spray-dried” KF [13], polymer-supported fluoride [14] and calcium fluoride supported on alkali metal fluoride [15], and tetraalkylammonium fluorides [16...
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Lin, X., Weng, Z. (2020). Copper-Mediated Nucleophilic Fluorination for Preparing Alkyl Fluorides. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-3896-9_27
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