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Electrochemical Fluorination for Preparing Aryl Fluorides

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Fluorination

Part of the book series: Synthetic Organofluorine Chemistry ((SYOC))

Introduction

Aryl fluorides including fluorinated heteroaromatic compounds are of much importance since they exhibit unique and pronounced biological activities. In fact, a number of partially fluorinated aryl compounds are currently used as pharmaceuticals and agrochemicals. Electrochemical partial fluorination of aromatic compounds has received much attention. Electrochemical fluorination of aryl compounds very often provides difluoro products as well as monofluoro products since monofluoro products have similar or a little lower oxidation potentials compared with starting aryl compounds. Furthermore, electrochemical fluorination of aryl compounds sometimes provides nonaromatic multifluorinated products. Therefore, electrochemical fluorination of aryl compounds is usually not so selective, and the yield is generally moderate to low [591,592,593,4]. However, electrochemical partial fluorination can be carried out under safe conditions without any hazardous reagents. This is a big...

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Author information

Authors and Affiliations

  1. Department of Electrochemistry, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan

    Toshio Fuchigami & Shinsuke Inagi

Authors
  1. Toshio Fuchigami
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  2. Shinsuke Inagi
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Corresponding author

Correspondence to Toshio Fuchigami .

Editor information

Editors and Affiliations

  1. Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

    Jinbo Hu

  2. Zhejiang Jiuzhou Pharmaceutical Co., Ltd, R&D Center, Taizhou, China

    Teruo Umemoto

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Fuchigami, T., Inagi, S. (2020). Electrochemical Fluorination for Preparing Aryl Fluorides. In: Hu, J., Umemoto, T. (eds) Fluorination. Synthetic Organofluorine Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-3896-9_25

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