Living Edition
| Editors: Jinbo Hu, Teruo Umemoto

Fluorinations in Organic Chemistry with Elemental Fluorine

  • Shlomo Rozen
Living reference work entry
DOI: https://doi.org/10.1007/978-981-10-1855-8_31-1


There is a common belief that elemental fluorine, even when diluted, is a very dangerous material, extremely reactive, and hence completely unselective. We should be scared even when we only think of it! We can find many statements in the literature reflecting this sentiment: “Highly hazardous,” “use with great care,” “only for well-trained professionals,” “but fluorine – watch it,” “highly toxic,” and so on. (We don’t wish to mention the names of those scientists who otherwise are doing great chemistry, but such statements can be found in some of the most respected publications). Usually such statements come from people who never worked with diluted fluorine and in many cases as an “explanation” why they will work with other reagents frequently inferior to F2/N2mixtures. It should be remembered that dilute fluorine is less dangerous and easier to work with than chlorine, for example, as if released it may spread to much shorter distances, its pressure regulators on the...

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Studies from this laboratory described in this review have been continuously supported by the Israel Science Foundation.


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Authors and Affiliations

  1. 1.School of Chemistry, Tel-Aviv UniversityTel-AvivIsrael