Living Edition
| Editors: Jinbo Hu, Teruo Umemoto

Fluorination of Aryl-Alkenyl-Iodonium Salts for Preparing Alkenyl Fluorides

  • Wenchao Qu
  • Ximin Li
Living reference work entry
DOI: https://doi.org/10.1007/978-981-10-1855-8_13-1

Brief Introduction

Alkenyl fluorides are important building blocks for constructing fluoroalkene moiety containing complex organic molecules, which may possess interesting biological activities and thus are particularly attractive to the pharmaceutical and agrochemical industries [1, 2, 3]. In addition, they can be used as monomers for polymerization and copolymerization to form fluoropolymers with certain special properties [4, 5, 6]. Numerous synthetic approaches have been developed to obtain selectively functionalized alkenyl fluorides which can be classified into five major categories based upon the organic reactions: (1) Horner-Wadsworth-Emmons, Horner-Wittig, Julia, Peterson, and Reformatsky-type olefination reactions, (2) hydrofluorination of alkynes, (3) electronic fluorination of alkenyl metals, (4) reductive elimination reaction of multi-halo compounds, and (5) various metal catalyzed cross-coupling reactions using fluoroalkenyl moiety containing synthons, etc. These...

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Citigroup of Biomedical Imaging CenterWeill Cornell MedicineNew YorkUSA
  2. 2.Avid Radiopharmaceuticals, IncPhiladelphiaUSA