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Psychosis and Physical Comorbidity

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Book cover Mental Health and Illness of Women

Part of the book series: Mental Health and Illness Worldwide ((MHIW))

Abstract

The life expectancy of men and women who suffer from psychotic illnesses is substantially shorter than that of the general population, with 90% of deaths attributable to the sequelae of physical illness. Suicide, accidents, and homicide account for the remaining 10%. Many of the responsible physical illnesses are brought on by heavy smoking, drinking, and lack of activity in the lives of individuals with psychosis. Some of the comorbidity may arise from psychotic illnesses sharing susceptibility genes with seemingly unrelated physical illnesses. Many diseases result from the adverse effects of antipsychotic treatment. It is also reported that the high mortality is due, to some degree, to delays in diagnosis and treatment for which physician stigmatization of mental illness is partially to blame. In many of the comorbid conditions, men and women are unequally affected. This chapter reviews the physical illnesses that complicate the lives of individuals with psychosis and suggests that the responsibility for preventing them is shared among patients, healthcare providers, and health systems. New ways of approaching this escalating problem are urgently needed.

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References

  • Attar R, Johansen MB, Valentin JB, Aagaard J, Jensen SE (2017) Treatment following myocardial infarction in patients with schizophrenia. PLoS One. https://doi.org/10.1371/journal.pone.0189289

    Article  Google Scholar 

  • Bailly-Salin P (2006) The mentally ill under nazi occupation in France. Int J Ment Health 35:11–35

    Article  Google Scholar 

  • Barker LC, Kurdyak P, Jacob B, Vigod SN (2018) Quality of diabetes care for individuals with comorbid chronic psychotic illness: a sex-based analysis. J Women’s Health 27:290–296

    Article  Google Scholar 

  • Bassett AS, Chow EWC, Weksberg R (2000) Chromosomal abnormalities and schizophrenia. Am J Med Genet 97:5–51

    Article  Google Scholar 

  • Bernard V, Young J, Binart N (2019) Prolactin – a pleiotropic factor in health and disease. Nat Rev Endocrinol. https://doi.org/10.1038/s41574-019-0194-6. [Epub ahead of print]

    Article  CAS  Google Scholar 

  • Bjornestad J, Davidson L, Joa I, Larsen TK, Hegelstad WTV, Langeveld J et al (2017) Antipsychotic treatment: experiences of fully recovered service users. J Ment Health 26:264–270

    Article  Google Scholar 

  • Blazer D (2018) Hearing loss: the silent risk for psychiatric disorders in late life. Psychiatr Clin N Am 41:19–27

    Article  Google Scholar 

  • Carson CM, Phillip N, Miller BJ (2017) Urinary tract infections in children and adolescents with acute psychosis. Schizophr Res 183:36–40

    Article  Google Scholar 

  • Chen SJ, Chao YL, Chen CY, Chang CM, Wu EC, Yeh HH et al (2012) Prevalence of autoimmune diseases in in-patients with schizophrenia: nationwide population-based study. Br J Psychiatry 200:374–380

    Article  Google Scholar 

  • Clancy MJ, Clarke MC, Connor DJ, Cannon M, Cotter DR (2014) The prevalence of psychosis in epilepsy; a systematic review and meta-analysis. BMC Psychiatry 14:75

    Article  Google Scholar 

  • Correll CU, Detraux J, De Lepeleire J, De Hert M (2015) Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder. World Psychiatry 14:119–136

    Article  Google Scholar 

  • Correll CU, Rubio JM, Kane JM (2018) What is the risk-benefit ratio of long-term antipsychotic treatment in people with schizophrenia? World Psychiatry 17:149–160

    Article  Google Scholar 

  • Curhan SG, Eliassen AH, Eavey RD, Wan M, Lin BM, Curhan GC (2017) Menopause and postmenopausal hormone therapy and risk of hearing loss. Menopause 24:1049–1056

    Article  Google Scholar 

  • Darpo B, Karnad DR, Badilini F, Florian J, Garnett CE, Kothari S et al (2014) Are women more susceptible than men to drug-induced QT prolongation? Concentration–QTc modelling in a phase 1 study with oral rac-sotalol. Br J Clin Pharmacol 77:522–531

    Article  CAS  Google Scholar 

  • De Hert M, Correll CU, Bobes J, Cetkovich-Bakmas M, Cohen D, Asai I et al (2011) Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care. World Psychiatry 10:52–77

    Article  Google Scholar 

  • Dekker JJM, Theunissen J, Van R, Peen J, Duurkoop P, Kikkert M (2010) Victimization of patients with severe psychiatric disorders: prevalence, risk factors, protective factors and consequences for mental health. A longitudinal study. BMC Pub Health 10:687

    Article  Google Scholar 

  • Dornquast C, Tomzik J, Reinhold T, Walle M, Mönter N, Berghöfer A (2017) To what extent are psychiatrists aware of the comorbid somatic illnesses of their patients with serious mental illnesses? – a cross-sectional secondary data analysis. BMC Health Serv Res 17:162

    Article  Google Scholar 

  • Eaton WE, Mortensen PB, Agerbo E, Byrne M, Mors O, Ewald H (2004) Coeliac disease and schizophrenia: population based case control study with linkage of Danish national registers. BMJ 328:438–439

    Article  Google Scholar 

  • Eaton WW, Byrne M, Ewald H, Mors O, Agerbo E, Mortensen PB (2006) Association of schizophrenia and autoimmune diseases: linkage of Danish national registers. Am J Psychiatry 163:521–528

    Article  Google Scholar 

  • Ehrlich C, Chester P, Kisely S, Crompton D, Kendall E (2018) Making sense of self-care practices at the intersection of severe mental illness and physical health – an Australian study. Health Soc Care Community 26:e47–e55

    Article  Google Scholar 

  • Eskelinen S, Sailas E, Joutsenniemi K, Holi M, Koskela TH, Suvisaari J (2017) Multiple physical healthcare needs among outpatients with schizophrenia: findings from a health examination study. Nord J Psychiatry 71:448–454

    Article  Google Scholar 

  • González-Rodríguez A, Catalán R, Penadés R, Ruiz Cortés VBN, Torra M, Seeman MV et al (2016) Antipsychotic response worsens with postmenopausal duration in women with schizophrenia. J Clin Psychopharmacol 36:580–587

    Article  Google Scholar 

  • Goubert L, Trompetter H (2017) Towards a science and practice of resilience in the face of pain. Eur J Pain 21:1301–1315

    Article  CAS  Google Scholar 

  • Green S, Beveridge E, Evans L, Trite J, Jayacodi S, Evered R et al (2018) Implementing guidelines on physical health in the acute mental health setting: a quality improvement approach. Int J Ment Health Syst 12:1

    Article  Google Scholar 

  • Griswold KS, Del Regno PA, Berger RC (2015) Recognition and differential diagnosis of psychosis in primary care. Am Fam Physician 91:856–863

    PubMed  Google Scholar 

  • Guerreiro DF, Navarro R, Silva M, Carvalho M, Gois C (2009) Psychosis secondary to traumatic brain injury. Brain Inj 23:358–336

    Article  CAS  Google Scholar 

  • Heald A, Livingston M, Yung A, De Hert MA (2017) Prescribing in schizophrenia and psychosis: increasing polypharmacy over time. Hum Psychopharmacol 32:e2579

    Article  Google Scholar 

  • Heinrich TW, Grahm G (2003) Hypothyroidism presenting as psychosis: myxedema madness revisited. Prim Care Companion J Clin Psychiatry 5:260–266

    Article  Google Scholar 

  • Hochner-Celnikier D, Manor O, Garbi B, Chajek-Shaul T (2005) Gender gap in cerebrovascular accidents: comparison of the extent, severity, and risk factors in men and women aged 45–65. Int J Fertil Womens Med 50:122–128

    PubMed  Google Scholar 

  • Horvitz-Lennon M, Kilbourne AM, Pincus HA (2006) From silos to bridges: meeting the general health care needs of adults with severe mental illnesses. Health Aff 25:659–669

    Article  Google Scholar 

  • Ittig S, Studerus E, Heitz U, Menghini-Müller S, Beck K, Egloff L et al (2017) Sex differences in prolactin levels in emerging psychosis: indication for enhanced stress reactivity in women. Schizophr Res 189:111–116

    Article  Google Scholar 

  • Iversen TSJ, Steen NE, Dieset I, Hope S, Mørch R, Gardsjord ES et al (2017) Side effect burden of antipsychotic drugs in real life – impact of gender and polypharmacy. Prog Neuro-Psychopharmacol Biol Psychiatry 82:263–271

    Article  Google Scholar 

  • Jia JM, Zhao J, Hu Z, Lindberg D, Li Z (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16:1627–1636

    Article  CAS  Google Scholar 

  • Jung SY, Park JW, Kim DH, Jun YH, Lee JS, Lee JE (2014) Mosaic turner syndrome associated with schizophrenia. Ann Pediatr Endocrinol Metab 19:42–44

    Article  Google Scholar 

  • Khalifeh H, Moran P, Borschmann R, Dean K, Hart C, Hogg J et al (2015) Domestic and sexual violence against patients with severe mental illness. Psychol Med 45:875–886

    Article  CAS  Google Scholar 

  • Marriott I, Huet-Hudson YM (2006) Sexual dimorphism in innate immune responses to infectious organisms. Immunol Res 34:177–192

    Article  CAS  Google Scholar 

  • McKee AC, Daneshvar DH (2015) The neuropathology of traumatic brain injury. Handb Clin Neurol 127:45–66

    Article  Google Scholar 

  • Meade CS, Sikkema KJ (2005) Voluntary HIV testing among adults with severe mental illness: frequency and associated factors. AIDS Behav 9:465–473

    Article  Google Scholar 

  • Mendrek A, Fattore L (2017) Sex differences in drug-induced psychosis. Curr Opin Behav Sci 13:152–157

    Article  Google Scholar 

  • Moore S, Shiers D, Daly B, Mitchell AJ, Gaughran F (2015) Promoting physical health for people with schizophrenia by reducing disparities in medical and dental care. Acta Psychiatr Scand 132:109–121

    Article  CAS  Google Scholar 

  • Niemi LT, Suvisaari JM, Tuulio-Henriksson A, Lönnqvist JK (2003) Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies. Schizophr Res 60:239–258

    Article  Google Scholar 

  • Oram S, Khalifeh H, Howard LM (2016) Violence against women and mental health. Lancet Psychiatry 4:159–170

    Article  Google Scholar 

  • Perälä J, Suvisaari J, Saarni SI, Kuoppasalmi K, Isometsä E, Pirkola S et al (2007) Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch Gen Psychiatry 64:19–28

    Article  Google Scholar 

  • Rademaker M (2001) Do women have more adverse drug reactions? Am J Clin Dermatol 2:349–351

    Article  CAS  Google Scholar 

  • Rado J (2017) The complex inter-relationship between diabetes and schizophrenia. Curr Diabetes Rev 13:195–212

    Article  Google Scholar 

  • Rasolofo-Razanamparany V, Menard D, Ratsitorahina M, Auregan G, Gicquel B, Chanteau S (2000) Transmission of tuberculosis in the prison of Antananarivo (Madagascar). Res Microbiol 151:785–795

    Article  CAS  Google Scholar 

  • Reddy DS (2014) Neurosteroids and their role in sex-specific epilepsies. Neurobiol Dis 72(PtB): 198–209

    Article  CAS  Google Scholar 

  • Reeve S, Emsley R, Sheaves B, Freeman D (2018) Disrupting sleep: the effects of sleep loss on psychotic experiences tested in an experimental study with mediation analysis. Schizophr Bull 44:662–671

    PubMed  Google Scholar 

  • Riecher-Rössler A (2017) Oestrogens, prolactin, hypothalamic-pituitary-gonadal axis, and schizophrenic psychoses. Lancet Psychiatry 4:63–72

    Article  Google Scholar 

  • Riecher-Rössler A, Löffler W, Munk-Jørgensen P (1997) What do we really know about late-onset schizophrenia? Eur Arch Psychiatry Clin Neurosci 247:195–208

    Article  Google Scholar 

  • Sahoo S, Grover S (2016) Hyponatremia and psychotropics. J Geriatr Ment Health 3:108–122

    Article  Google Scholar 

  • Seeman P (2011) All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2High receptors. CNS Neurosci Therap 17:118–132

    Article  CAS  Google Scholar 

  • Seeman MV (2012) Antipsychotic-induced somnolence in mothers with schizophrenia. Psychiatry Q 83:83–89

    Article  Google Scholar 

  • Seeman MV (2015) The role of mental health services in addressing HIV infection among women with serious mental illness. Psychiatr Serv 66:966–974

    Article  Google Scholar 

  • Seeman MV (2017) Breast cancer prevention and treatment in women with severe mental illness. Int J Womens Health Wellness 3:064

    Google Scholar 

  • Severance EG, Yolken RH, Eaton WW (2016) Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling. Schizophr Res 176:23–35

    Article  Google Scholar 

  • Solmi M, Murru A, Pacchiarotti I, Undurraga J, Veronese N, Fornaro M et al (2017) Safety, tolerability, and risks associated with first- and second-generation antipsychotics: a state-of-the-art clinical review. Ther Clin Risk Manag 13:757–777

    Article  CAS  Google Scholar 

  • Sørensen HJ, Nielsen PR, Benros ME, Pedersen CB, Mortensen PB (2015) Somatic diseases and conditions before the first diagnosis of schizophrenia: a nationwide population-based cohort study in more than 900 000 individuals. Schizophr Bull 41:513–521

    Article  Google Scholar 

  • Tenback DE, van Harten PN (2011) Epidemiology and risk factors for (tardive) dyskinesia. Int Rev Neurobiol 98:211–230

    Article  CAS  Google Scholar 

  • Torrey EF, Yolken RH (2017) Schizophrenia and infections: the eyes have it. Schizophr Bull 43:247–252

    PubMed  Google Scholar 

  • Turrone P, Seeman MV, Silvestri S (2000) Estrogen receptor activation and tardive dyskinesia. Can J Psychiatr 45:288–290

    Article  CAS  Google Scholar 

  • Ungar T, Goldman S, Marcus M (2013) Reversed shared care in mental health: bringing primary physical health care to psychiatric patients. Can J Commun Ment Health 32:1–16

    Article  Google Scholar 

  • Walker ER, McGee RE, Druss BG (2015) Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiat 72:334–341

    Article  Google Scholar 

  • Wang MT, Tsai CL, Lin CW, Yeh CB, Wang YH, Lin HL (2017) Association between antipsychotic agents and risk of acute respiratory failure in patients with chronic obstructive pulmonary disease. JAMA Psychiat 74:252–260

    Article  Google Scholar 

  • Yarborough BJH, Stumbo SP, Perrin NA, Hanson GC, Muench J, Green CA (2018) Effects of primary care clinician beliefs and perceived organizational facilitators on the delivery of preventive care to individuals with mental illnesses. BMC Fam Pract 19:16

    Article  Google Scholar 

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Correspondence to Mary V. Seeman .

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Seeman, M.V. (2019). Psychosis and Physical Comorbidity. In: Chandra, P., Herrman, H., Fisher, J., Riecher-Rössler, A. (eds) Mental Health and Illness of Women. Mental Health and Illness Worldwide. Springer, Singapore. https://doi.org/10.1007/978-981-10-0371-4_20-1

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  • DOI: https://doi.org/10.1007/978-981-10-0371-4_20-1

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