(Neurobiology of) Dementia: Causes, Presentation and Management

  • David Bensamoun
  • Aurélie Mouton
  • Eric Ettore
  • Philippe Robert
  • Renaud David
Living reference work entry
Part of the Mental Health and Illness Worldwide book series (MHIW)


Alzheimer’s disease is the main type of dementia in aging populations and is characterized by a progressive impairment in cognitive abilities associated with behavioral and psychological changes and a progressive loss of autonomy. Other dementia syndromes in aging can, however, be observed but their frequency is lower. The present chapter will describe the clinical course and aetiologies of the main dementia syndromes in elderly populations as well as the main therapeutic options for the management of dementia.


Dementia Alzheimer’s disease Vascular dementia 


  1. Aarsland D, Kurz MW (2010) The epidemiology of dementia associated with Parkinson disease. J Neurol Sci 289(1–2):18–22CrossRefPubMedGoogle Scholar
  2. Abbott RD, White LR, Ross GW, Masaki KH, Curb JD, Petrovitch H (2004) Walking and dementia in physically capable elderly men. JAMA 292(12):1447–1453CrossRefPubMedGoogle Scholar
  3. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH (2011) The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):270–279CrossRefPubMedPubMedCentralGoogle Scholar
  4. APA (2013) DSM-V: Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, ArlingtonGoogle Scholar
  5. Baldi I, Lebailly P, Mohammed-Brahim B, Letenneur L, Dartigues JF, Brochard P (2003) Neurodegenerative diseases and exposure to pesticides in the elderly. Am J Epidemiol 157(5):409–414CrossRefPubMedGoogle Scholar
  6. Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS (2006) The effect of social networks on the relation between Alzheimer’s disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol 5(5):406–412CrossRefPubMedGoogle Scholar
  7. Ben-Sadoun G, Sacco G, Manera V, Bourgeois J, Konig A, Foulon P, Fosty B, Bremond F, d’Arripe-Longueville F, Robert P (2016) Physical and cognitive stimulation using an exergame in subjects with normal aging, mild and moderate cognitive impairment. J Alzheimers Dis 53(4):1299–1314CrossRefPubMedGoogle Scholar
  8. Bian L, Yang JD, Guo TW, Sun Y, Duan SW, Chen WY, Pan YX, Feng GY, He L (2004) Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese. Neurology 63(2):241–245CrossRefPubMedGoogle Scholar
  9. Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P (2006) Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 5(1):64–74CrossRefPubMedGoogle Scholar
  10. Boeve BF (2011) The multiple phenotypes of corticobasal syndrome and corticobasal degeneration: implications for further study. J Mol Neurosci 45(3):350–353CrossRefPubMedGoogle Scholar
  11. Bonnechere B, Jansen B, Omelina L, Van Sint Jan S (2016) The use of commercial video games in rehabilitation: a systematic review. Int J Rehabil Res 39(4):277–290CrossRefPubMedGoogle Scholar
  12. Brunnstrom H, Gustafson L, Passant U, Englund E (2009) Prevalence of dementia subtypes: a 30-year retrospective survey of neuropathological reports. Arch Gerontol Geriatr 49(1):146–149CrossRefPubMedGoogle Scholar
  13. Cummings JL (1997) The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology 48(5 Suppl 6):S10–S16CrossRefPubMedGoogle Scholar
  14. de Oliveira AM, Radanovic M, de Mello PC, Buchain PC, Vizzotto AD, Celestino DL, Stella F, Piersol CV, Forlenza OV (2015) Nonpharmacological interventions to reduce behavioral and psychological symptoms of dementia: a systematic review. Biomed Res Int 2015:218980PubMedPubMedCentralGoogle Scholar
  15. den Heijer T, Vermeer SE, van Dijk EJ, Prins ND, Koudstaal PJ, Hofman A, Breteler MM (2003) Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia 46(12):1604–1610CrossRefGoogle Scholar
  16. De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV (2012) Alzheimer’s disease. Subcell Biochem 65:329–352CrossRefPubMedGoogle Scholar
  17. Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, Gauthier S, Hampel H, Jicha GA, Meguro K, O’Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza LC, Stern Y, Visser PJ, Scheltens P (2010) Revising the definition of Alzheimer’s disease: a new lexicon. Lancet Neurol 9(11):1118–1127CrossRefPubMedGoogle Scholar
  18. Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL (2014) Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurol 13(6):614–629CrossRefPubMedGoogle Scholar
  19. Duyckaerts C, Hauw JJ (2003) Lewy bodies, a misleading marker for Parkinson’s disease? Bull Acad Natl Med 187(2):277–292. discussion 292-273PubMedGoogle Scholar
  20. Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JC, Breteler MM (2002) Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 287(24):3223–3229CrossRefPubMedGoogle Scholar
  21. Fleminger S, Oliver DL, Lovestone S, Rabe-Hesketh S, Giora A (2003) Head injury as a risk factor for Alzheimer’s disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry 74(7):857–862CrossRefPubMedPubMedCentralGoogle Scholar
  22. Fratiglioni L, Paillard-Borg S, Winblad B (2004) An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol 3(6):343–353CrossRefPubMedGoogle Scholar
  23. Gitlin LN, Kales HC, Lyketsos CG (2012) Nonpharmacologic management of behavioral symptoms in dementia. JAMA 308(19):2020–2029CrossRefPubMedPubMedCentralGoogle Scholar
  24. Goodman RA, Lochner KA, Thambisetty M, Wingo TS, Posner SF, Ling SM (2016) Prevalence of dementia subtypes in U.S. Medicare fee-for-service beneficiaries, 2011–2013. Alzheimers Dement 13(1):28–37Google Scholar
  25. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S, C. o. E. American Heart Association Stroke Council, C. o. C. N. C. o. C. R. Prevention, Intervention, S. Council on Cardiovascular and Anesthesia (2011) Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 42(9):2672–2713CrossRefPubMedPubMedCentralGoogle Scholar
  26. Gorno-Tempini ML, Brambati SM, Ginex V, Ogar J, Dronkers NF, Marcone A, Perani D, Garibotto V, Cappa SF, Miller BL (2008) The logopenic/phonological variant of primary progressive aphasia. Neurology 71(16):1227–1234CrossRefPubMedPubMedCentralGoogle Scholar
  27. Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF, Ogar JM, Rohrer JD, Black S, Boeve BF, Manes F, Dronkers NF, Vandenberghe R, Rascovsky K, Patterson K, Miller BL, Knopman DS, Hodges JR, Mesulam MM, Grossman M (2011) Classification of primary progressive aphasia and its variants. Neurology 76(11):1006–1014CrossRefPubMedPubMedCentralGoogle Scholar
  28. Gray SL, Anderson ML, Dublin S, Hanlon JT, Hubbard R, Walker R, Yu O, Crane PK, Larson EB (2015) Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 175(3):401–407CrossRefPubMedPubMedCentralGoogle Scholar
  29. Gros A, Bensamoun D, Manera V, Fabre R, Zacconi-Cauvin A, Thummler S, Benoit M, Robert P, David R (2016) Recommendations for the use of ICT in elderly populations with affective disorders. Front Aging Neurosci 8(269)Google Scholar
  30. Grossman M (2012) The non-fluent/agrammatic variant of primary progressive aphasia. Lancet Neurol 11(6):545–555CrossRefPubMedPubMedCentralGoogle Scholar
  31. Heude B, Ducimetiere P, Berr C, Study EVA (2003) Cognitive decline and fatty acid composition of erythrocyte membranes–The EVA Study. Am J Clin Nutr 77(4):803–808PubMedGoogle Scholar
  32. Huey ED, Putnam KT, Grafman J (2006) A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia. Neurology 66(1):17–22CrossRefPubMedPubMedCentralGoogle Scholar
  33. Incalzi RA, Gemma A, Marra C, Capparella O, Fuso L, Carbonin P (1997) Verbal memory impairment in COPD: its mechanisms and clinical relevance. Chest 112(6):1506–1513CrossRefPubMedGoogle Scholar
  34. Jack CR Jr, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, Shaw LM, Vemuri P, Wiste HJ, Weigand SD, Lesnick TG, Pankratz VS, Donohue MC, Trojanowski JQ (2013) Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 12(2):207–216CrossRefPubMedPubMedCentralGoogle Scholar
  35. Jansen WJ, Handels RL, Visser PJ, Aalten P, Bouwman F, Claassen J, van Domburg P, Hoff E, Hoogmoed J, Leentjens AF, Rikkert MO, Oleksik AM, Smid M, Scheltens P, Wolfs C, Verhey F, Ramakers IH (2016) The diagnostic and prognostic value of neuropsychological assessment in memory clinic patients. J Alzheimers Dis 55(2):679–689Google Scholar
  36. Jellinger KA (2008) Morphologic diagnosis of “vascular dementia” – a critical update. J Neurol Sci 270(1-2):1–12CrossRefPubMedGoogle Scholar
  37. Kalaria RN, Maestre GE, Arizaga R, Friedland RP, Galasko D, Hall K, Luchsinger JA, Ogunniyi A, Perry EK, Potocnik F, Prince M, Stewart R, Wimo A, Zhang ZX, Antuono P, G. World Federation of Neurology Dementia Research (2008) Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol 7(9):812–826CrossRefPubMedPubMedCentralGoogle Scholar
  38. Kales HC, Gitlin LN, Lyketsos CG (2015) Assessment and management of behavioral and psychological symptoms of dementia. BMJ 350:h369CrossRefPubMedPubMedCentralGoogle Scholar
  39. Kortte KB, Rogalski EJ (2013) Behavioural interventions for enhancing life participation in behavioural variant frontotemporal dementia and primary progressive aphasia. Int Rev Psychiatry 25(2):237–245CrossRefPubMedPubMedCentralGoogle Scholar
  40. Kurz A, Kurz C, Ellis K, Lautenschlager NT (2014) What is frontotemporal dementia? Maturitas 79(2):216–219CrossRefPubMedGoogle Scholar
  41. Letenneur L, Gilleron V, Commenges D, Helmer C, Orgogozo JM, Dartigues JF (1999) Are sex and educational level independent predictors of dementia and Alzheimer’s disease? Incidence data from the PAQUID project. J Neurol Neurosurg Psychiatry 66(2):177–183CrossRefPubMedPubMedCentralGoogle Scholar
  42. Ling H (2016) Clinical approach to progressive supranuclear palsy. J Mov Disord 9(1):3–13CrossRefPubMedPubMedCentralGoogle Scholar
  43. Ling H, O’Sullivan SS, Holton JL, Revesz T, Massey LA, Williams DR, Paviour DC, Lees AJ (2010) Does corticobasal degeneration exist? A clinicopathological re-evaluation. Brain 133(Pt 7):2045–2057CrossRefPubMedGoogle Scholar
  44. Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, Goetz CG, Golbe LI, Grafman J, Growdon JH, Hallett M, Jankovic J, Quinn NP, Tolosa E, Zee DS (1996) Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 47(1):1–9CrossRefPubMedGoogle Scholar
  45. Luchsinger JA, Tang MX, Miller J, Green R, Mayeux R (2007) Relation of higher folate intake to lower risk of Alzheimer disease in the elderly. Arch Neurol 64(1):86–92CrossRefPubMedGoogle Scholar
  46. Lumsden J, Edwards EA, Lawrence NS, Coyle D, Munafo MR (2016) Gamification of cognitive assessment and cognitive training: a systematic review of applications and efficacy. JMIR Serious Games 4(2):e11CrossRefPubMedPubMedCentralGoogle Scholar
  47. Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC (2000) Mental and behavioral disturbances in dementia: findings from the cache county study on memory in aging. Am J Psychiatry 157(5):708–714CrossRefPubMedGoogle Scholar
  48. Magnin E, Teichmann M, Martinaud O, Moreaud O, Ryff I, Belliard S, Pariente J, Moulin T, Vandel P, Demonet JF (2015) Specificities of the logopenic variant of primary progressive aphasia. Rev Neurol (Paris) 171(1):16–30CrossRefGoogle Scholar
  49. Manera V, Petit PD, Derreumaux A, Orvieto I, Romagnoli M, Lyttle G, David R, Robert PH (2015) ‘Kitchen and cooking,’ a serious game for mild cognitive impairment and Alzheimer’s disease: a pilot study. Front Aging Neurosci 7:24CrossRefPubMedPubMedCentralGoogle Scholar
  50. McKeith I (2004) Dementia with Lewy bodies. Dialogues Clin Neurosci 6(3):333–341PubMedPubMedCentralGoogle Scholar
  51. McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65(12):1863–1872CrossRefPubMedGoogle Scholar
  52. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):263–269CrossRefPubMedPubMedCentralGoogle Scholar
  53. Mesulam MM (2001) Primary progressive aphasia. Ann Neurol 49(4):425–432CrossRefPubMedGoogle Scholar
  54. Morris JC, Blennow K, Froelich L, Nordberg A, Soininen H, Waldemar G, Wahlund LO, Dubois B (2014) Harmonized diagnostic criteria for Alzheimer’s disease: recommendations. J Intern Med 275(3):204–213CrossRefPubMedGoogle Scholar
  55. O’Brien JT, Burns A (2011) Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for Psychopharmacology. J Psychopharmacol 25(8):997–1019CrossRefPubMedGoogle Scholar
  56. O’Brien JT, Thomas A (2015) Vascular dementia. Lancet 386(10004):1698–1706CrossRefPubMedGoogle Scholar
  57. Ott A, Andersen K, Dewey ME, Letenneur L, Brayne C, Copeland JR, Dartigues JF, Kragh-Sorensen P, Lobo A, Martinez-Lage JM, Stijnen T, Hofman A, Launer LJ, E. I. R. Group (2004) Effect of smoking on global cognitive function in nondemented elderly. Neurology 62(6):920–924CrossRefPubMedGoogle Scholar
  58. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild cognitive impairment: clinical characterization and outcome. Arch Neuro 56:303–308CrossRefGoogle Scholar
  59. Petrovitch H, White LR, Izmirilian G, Ross GW, Havlik RJ, Markesbery W, Nelson J, Davis DG, Hardman J, Foley DJ, Launer LJ (2000) Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study. Neurobiol Aging 21(1):57–62CrossRefPubMedGoogle Scholar
  60. Plassman BL, Havlik RJ, Steffens DC, Helms MJ, Newman TN, Drosdick D, Phillips C, Gau BA, Welsh-Bohmer KA, Burke JR, Guralnik JM, Breitner JC (2000) Documented head injury in early adulthood and risk of Alzheimer’s disease and other dementias. Neurology 55(8):1158–1166CrossRefPubMedGoogle Scholar
  61. Press-Sandler O, Freud T, Volkov I, Peleg R, Press Y (2016) Aromatherapy for the treatment of patients with behavioral and psychological symptoms of dementia: a descriptive analysis of RCTs. J Altern Complement Med 22(6):422–428CrossRefPubMedGoogle Scholar
  62. Qiu C, Winblad B, Fratiglioni L (2005) The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol 4(8):487–499CrossRefPubMedGoogle Scholar
  63. Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134(Pt 9):2456–2477CrossRefPubMedPubMedCentralGoogle Scholar
  64. Ravaglia G, Forti P, Maioli F, Martelli M, Servadei L, Brunetti N, Porcellini E, Licastro F (2005) Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 82(3):636–643PubMedGoogle Scholar
  65. Reese TR, Thiel DJ, Cocker KE (2016) Behavioral disorders in dementia: appropriate nondrug interventions and antipsychotic use. Am Fam Physician 94(4):276–282PubMedGoogle Scholar
  66. Reppas-Rindlisbacher CE, Fischer HD, Fung K, Gill SS, Seitz D, Tannenbaum C, Austin PC, Rochon PA (2016) Anticholinergic drug burden in persons with dementia taking a cholinesterase inhibitor: the effect of multiple physicians. J Am Geriatr Soc 64(3):492–500CrossRefPubMedPubMedCentralGoogle Scholar
  67. Robert PH, Konig A, Andrieu S, Bremond F, Chemin I, Chung PC, Dartigues JF, Dubois B, Feutren G, Guillemaud R, Kenisberg PA, Nave S, Vellas B, Verhey F, Yesavage J, Mallea P (2013) Recommendations for ICT use in Alzheimer’s disease assessment: Monaco CTAD expert meeting. J Nutr Health Aging 17(8):653–660CrossRefPubMedGoogle Scholar
  68. Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A et al (1993) Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 43(2):250–260CrossRefPubMedGoogle Scholar
  69. Rondeau V (2002) A review of epidemiologic studies on aluminum and silica in relation to Alzheimer’s disease and associated disorders. Rev Environ Health 17(2):107–121CrossRefPubMedPubMedCentralGoogle Scholar
  70. Rondeau V, Commenges D, Jacqmin-Gadda H, Dartigues JF (2000) Relation between aluminum concentrations in drinking water and Alzheimer’s disease: an 8-year follow-up study. Am J Epidemiol 152(1):59–66CrossRefPubMedPubMedCentralGoogle Scholar
  71. Saczynski JS, Pfeifer LA, Masaki K, Korf ES, Laurin D, White L, Launer LJ (2006) The effect of social engagement on incident dementia: the Honolulu-Asia aging study. Am J Epidemiol 163(5):433–440CrossRefPubMedGoogle Scholar
  72. Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE (2004) Cholesterol and Alzheimer’s disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr Drug Targets 5(6):517–528CrossRefPubMedGoogle Scholar
  73. Sarazin M, Berr C, De Rotrou J, Fabrigoule C, Pasquier F, Legrain S, Michel B, Puel M, Volteau M, Touchon J, Verny M, Dubois B (2007) Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study. Neurology 69(19):1859–1867CrossRefPubMedGoogle Scholar
  74. Schrag A, Ben-Shlomo Y, Quinn NP (1999) Prevalence of progressive supranuclear palsy and multiple system atrophy: a cross-sectional study. Lancet 354(9192):1771–1775CrossRefPubMedGoogle Scholar
  75. Selkoe DJ, Hardy J (2016) The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med 8(6):595–608CrossRefPubMedPubMedCentralGoogle Scholar
  76. Stewart R, Masaki K, Xue QL, Peila R, Petrovitch H, White LR, Launer LJ (2005) A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Arch Neurol 62(1):55–60CrossRefPubMedGoogle Scholar
  77. Tzourio C, Dufouil C, Ducimetiere P, Alperovitch A (1999) Cognitive decline in individuals with high blood pressure: a longitudinal study in the elderly. EVA Study Group. Epidemiology of Vascular Aging. Neurology 53(9):1948–1952CrossRefPubMedGoogle Scholar
  78. Waldemar G, Burns A (2016) Managing behavioral and psychological symptoms in ALzheimer’s disease. O. U. Press, Oxford, pp 71–84Google Scholar
  79. Walker Z, Possin KL, Boeve BF, Aarsland D (2015) Lewy body dementias. Lancet 386(10004):1683–1697CrossRefPubMedGoogle Scholar
  80. Wang L, Larson EB, Bowen JD, van Belle G (2006) Performance-based physical function and future dementia in older people. Arch Intern Med 166(10):1115–1120CrossRefPubMedGoogle Scholar
  81. Weuve J, Kang JH, Manson JE, Breteler MM, Ware JH, Grodstein F (2004) Physical activity, including walking, and cognitive function in older women. JAMA 292(12):1454–1461CrossRefPubMedGoogle Scholar
  82. Whitmer RA, Gunderson EP, Barrett-Connor E, Quesenberry CP Jr, Yaffe K (2005) Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ 330(7504):1360CrossRefPubMedPubMedCentralGoogle Scholar
  83. Williams DR, de Silva R, Paviour DC, Pittman A, Watt HC, Kilford L, Holton JL, Revesz T, Lees AJ (2005) Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson’s syndrome and PSP-parkinsonism. Brain 128(Pt 6):1247–1258CrossRefPubMedGoogle Scholar
  84. Williams DR, Holton JL, Strand K, Revesz T, Lees AJ (2007) Pure akinesia with gait freezing: a third clinical phenotype of progressive supranuclear palsy. Mov Disord 22(15):2235–2241CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2016

Authors and Affiliations

  • David Bensamoun
    • 1
  • Aurélie Mouton
    • 1
  • Eric Ettore
    • 1
  • Philippe Robert
    • 1
  • Renaud David
    • 1
  1. 1.Centre Memoire de Ressources et de RechercheCoBTek “Cognition Behaviour Technology” Research Team, Institut Claude Pompidou, Nice University HospitalNiceFrance

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