Encyclopedia of Lipidomics

Living Edition
| Editors: Markus R. Wenk

Glycerophospholipids

Living reference work entry
DOI: https://doi.org/10.1007/978-94-007-7864-1_58-1

Synonyms

Definition

Glycerophospholipids are a class of lipids comprising several subclasses. Their basic building blocks (Fig. 1) are:
  • Glycerol

  • A phosphate group, esterified to a terminal hydroxyl group of glycerol

  • One or two fatty acids, linked via either acyl-, alkyl-, or alkenyl-bonds to the remaining hydroxyl groups. Although the length and degree of unsaturation of the fatty acids vary, phospholipids typically contain a saturated fatty acid at the sn-1 position and an unsaturated or polyunsaturated fatty acid at the sn-2 position.

  • A head group, determining the subclass

Keywords

Fatty Acid Composition Head Group Vinyl Ether Ethanolamine Plasmalogens Choline Phosphotransferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Braverman NE, Moser AB. Functions of plasmalogen lipids in health and disease. Biochim Biophys Acta Mol Basis Dis. 2012;1822:1442–52. doi:10.1016/j.bbadis.2012.05.008.CrossRefGoogle Scholar
  2. Fagone P, Jackowski S. Membrane phospholipid synthesis and endoplasmic reticulum function. J Lipid Res. 2009;50(Suppl):S311–6. doi:10.1194/jlr.R800049-JLR200.PubMedPubMedCentralGoogle Scholar
  3. Fahy E, Subramaniam S, Brown HA, et al. A comprehensive classification system for lipids. J Lipid Res. 2005;46:839–61. doi:10.1194/jlr.E400004-JLR200.CrossRefPubMedGoogle Scholar
  4. Okudaira M, Inoue A, Shuto A, et al. Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MS. J Lipid Res. 2014;55:2178–92. doi:10.1194/jlr.D048439.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Shindou H, Shimizu T. Acyl-CoA:lysophospholipid acyltransferases. J Biol Chem. 2009;284:1–5. doi:10.1074/jbc.R800046200.CrossRefPubMedGoogle Scholar
  6. Van Meer G, Voelker DR, Feigenson GW. Membrane lipids: where they are and how they behave. Nat Rev Mol Cell Biol. 2008;9:112–24. doi:10.1038/nrm2330.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  1. 1.Zentrum für Medizinische Forschung (ZMF)Medizinische Universität GrazGrazAustria