Definition
Drift of an analytical method is a gradual, directional change of the method’s performance as a function of time. In other words, we observe drift in a given method, when in a series of measurements of identical samples a gradual increase or decrease of performance (for example, its precision, accuracy, or simply measured values) occurs over time.
Drift can be caused by changes in chromatographic performance (e.g., column aging), contamination or dirtying of the ion source, changes in quality of chemicals during the analysis, sample decomposition during the time it awaits its measurement, background intensity changes, and instrumental drift or offset (Kamleh et al. 2012).
There are several ways of reducing drift or correcting for it. It can be reduced by analyzing samples in small batches batch effect only and thereby minimizing the time between the acquisition of the first and the last sample (Zelena et al. 2009). Furthermore, equilibration of the analytical system until...
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Klose, C. (2015). Sample Handling and Automation: Drift. In: Wenk, M. (eds) Encyclopedia of Lipidomics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7864-1_55-1
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DOI: https://doi.org/10.1007/978-94-007-7864-1_55-1
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