Introduction
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, which accounts for about 85%–90% of all the cases. It is the sixth most common cancer worldwide and ranks third in overall cancer-caused mortalities. More than 782, 000 cases of this disease were diagnosed in 2012, and in the same year it caused 746,000 deaths. Even though the majority of HCC cases (> 83%) occur in less developed regions, especially sub-Saharan Africa and Eastern and Southeastern Asia, the number of new cases in America and Europe is also on the rise in recent years, which makes HCC a worldwide health threat.
The high mortality of HCC is due to various contributing factors, including the lack of monitoring in populations at high-risk, insufficient diagnostic methods, and limited treatment options. Even though in recent decades the understanding of epidemiological factors and molecular mechanisms associated with HCC has improved a lot as well as disease treatment, the prognosis...
References
Baniasadi H, Gowda GAN, Gu H, Zeng A, Zhuang S, Skill N, et al. Targeted metabolic profiling of hepatocellular carcinoma and hepatitis C using LC-MS/MS. Electrophoresis. 2013;34(19):2910–7.
Bell AW. Lipid metabolism in liver and selected tissues and in the whole body of ruminant animals. Prog Lipid Res. 1979;18(3):117–64.
Chen T, Xie G, Wang X, Fan J, Qui Y, Zheng X, et al. Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma. Mol Cell Proteomics. 2011;10(11):1.
Chen S, Kong H, Lu X, Li Y, Yin P, Zeng Z, et al. Pseudotargeted metabolomics method and its application in serum biomarker discovery for hepatocellular carcinoma based on ultra high-performance liquid chromatography/triple quadrupole mass spectrometry. Anal Chem. 2013a;85(17):8326–33.
Chen S, Yin P, Zhao X, Xing W, Hu C, Zhou L, et al. Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS. Electrophoresis. 2013b;34(19):2848–56.
Kumar K, Sachdanandam P, Arivazhagan R. Studies on the changes in plasma-lipids and lipoproteins in patients with benign and malignant breast-cancer. Biochem Int. 1991;23(3):581–9.
Legaspi A, Jeevanandam M, Starnes HF, Brennan MF. Whole-body lipid and energy-metabolism in the cancer-patient. Metabolism. 1987;36(10):958–63.
Liang Q, Wang C, Li B, Zhang A-h. Lipidomics analysis based on liquid chromatography mass spectrometry for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. RSC Adv. 2015;5(78):63711–8.
Linkous AG, Yazlovitskaya EM, Hallahan DE. Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis. J Natl Cancer Inst. 2010;102(18):1398–412.
Ma X, Chong L, Tian R, Shi R, TY H, Ouyang Z, et al. Identification and quantitation of lipid C═C location isomers: a shotgun lipidomics approach enabled by photochemical reaction. Proc Natl Acad Sci U S A. 2016;113(10):2573–8.
Morita Y, Sakaguchi T, Ikegami K, Goto-Inoue N, Hayasaka T, Vu Thi H, et al. Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression. J Hepatol. 2013;59(2):292–9.
Ressom HW, Xiao JF, Tuli L, Varghese RS, Zhou B, Tsai T-H, et al. Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis. Anal Chim Acta. 2012;743:90–100.
Spener F, Lagarde M, Geloen A, Record M. What is lipidomics? Eur J Lipid Sci Technol. 2003;105(9):481–2.
Wenk MR. Lipidomics: new tools and applications. Cell. 2010;143(6):888–95.
Yang L, Li M, Shan Y, Shen S, Bai Y, Liu H. Recent advances in lipidomics for disease research. J Sep Sci. 2016;39(1):38–50.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media B.V.
About this entry
Cite this entry
Shen, S., Bai, Y., Liu, H. (2018). Lipid Biomarker for Liver Cancer. In: Wenk, M. (eds) Encyclopedia of Lipidomics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7864-1_171-1
Download citation
DOI: https://doi.org/10.1007/978-94-007-7864-1_171-1
Received:
Accepted:
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-7864-1
Online ISBN: 978-94-007-7864-1
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences