Skip to main content

Lipid Biomarker for Liver Cancer

  • Living reference work entry
  • First Online:
Encyclopedia of Lipidomics
  • 123 Accesses

Introduction

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, which accounts for about 85%–90% of all the cases. It is the sixth most common cancer worldwide and ranks third in overall cancer-caused mortalities. More than 782, 000 cases of this disease were diagnosed in 2012, and in the same year it caused 746,000 deaths. Even though the majority of HCC cases (> 83%) occur in less developed regions, especially sub-Saharan Africa and Eastern and Southeastern Asia, the number of new cases in America and Europe is also on the rise in recent years, which makes HCC a worldwide health threat.

The high mortality of HCC is due to various contributing factors, including the lack of monitoring in populations at high-risk, insufficient diagnostic methods, and limited treatment options. Even though in recent decades the understanding of epidemiological factors and molecular mechanisms associated with HCC has improved a lot as well as disease treatment, the prognosis...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Baniasadi H, Gowda GAN, Gu H, Zeng A, Zhuang S, Skill N, et al. Targeted metabolic profiling of hepatocellular carcinoma and hepatitis C using LC-MS/MS. Electrophoresis. 2013;34(19):2910–7.

    CAS  PubMed  Google Scholar 

  • Bell AW. Lipid metabolism in liver and selected tissues and in the whole body of ruminant animals. Prog Lipid Res. 1979;18(3):117–64.

    Article  CAS  PubMed  Google Scholar 

  • Chen T, Xie G, Wang X, Fan J, Qui Y, Zheng X, et al. Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma. Mol Cell Proteomics. 2011;10(11):1.

    Article  Google Scholar 

  • Chen S, Kong H, Lu X, Li Y, Yin P, Zeng Z, et al. Pseudotargeted metabolomics method and its application in serum biomarker discovery for hepatocellular carcinoma based on ultra high-performance liquid chromatography/triple quadrupole mass spectrometry. Anal Chem. 2013a;85(17):8326–33.

    Article  CAS  PubMed  Google Scholar 

  • Chen S, Yin P, Zhao X, Xing W, Hu C, Zhou L, et al. Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS. Electrophoresis. 2013b;34(19):2848–56.

    CAS  PubMed  Google Scholar 

  • Kumar K, Sachdanandam P, Arivazhagan R. Studies on the changes in plasma-lipids and lipoproteins in patients with benign and malignant breast-cancer. Biochem Int. 1991;23(3):581–9.

    CAS  PubMed  Google Scholar 

  • Legaspi A, Jeevanandam M, Starnes HF, Brennan MF. Whole-body lipid and energy-metabolism in the cancer-patient. Metabolism. 1987;36(10):958–63.

    Article  CAS  PubMed  Google Scholar 

  • Liang Q, Wang C, Li B, Zhang A-h. Lipidomics analysis based on liquid chromatography mass spectrometry for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. RSC Adv. 2015;5(78):63711–8.

    Article  CAS  Google Scholar 

  • Linkous AG, Yazlovitskaya EM, Hallahan DE. Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis. J Natl Cancer Inst. 2010;102(18):1398–412.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ma X, Chong L, Tian R, Shi R, TY H, Ouyang Z, et al. Identification and quantitation of lipid C═C location isomers: a shotgun lipidomics approach enabled by photochemical reaction. Proc Natl Acad Sci U S A. 2016;113(10):2573–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Morita Y, Sakaguchi T, Ikegami K, Goto-Inoue N, Hayasaka T, Vu Thi H, et al. Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression. J Hepatol. 2013;59(2):292–9.

    Article  CAS  PubMed  Google Scholar 

  • Ressom HW, Xiao JF, Tuli L, Varghese RS, Zhou B, Tsai T-H, et al. Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis. Anal Chim Acta. 2012;743:90–100.

    Article  CAS  PubMed  Google Scholar 

  • Spener F, Lagarde M, Geloen A, Record M. What is lipidomics? Eur J Lipid Sci Technol. 2003;105(9):481–2.

    Article  Google Scholar 

  • Wenk MR. Lipidomics: new tools and applications. Cell. 2010;143(6):888–95.

    Article  CAS  PubMed  Google Scholar 

  • Yang L, Li M, Shan Y, Shen S, Bai Y, Liu H. Recent advances in lipidomics for disease research. J Sep Sci. 2016;39(1):38–50.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Huwei Liu .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Science+Business Media B.V.

About this entry

Cite this entry

Shen, S., Bai, Y., Liu, H. (2018). Lipid Biomarker for Liver Cancer. In: Wenk, M. (eds) Encyclopedia of Lipidomics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7864-1_171-1

Download citation

  • DOI: https://doi.org/10.1007/978-94-007-7864-1_171-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-7864-1

  • Online ISBN: 978-94-007-7864-1

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics