Encyclopedia of Lipidomics

Living Edition
| Editors: Markus R. Wenk

Supercritical Fluid Extraction: Modifier

  • Hiroaki Takeda
  • Yoshihiro Izumi
  • Takeshi Bamba
Living reference work entry
DOI: https://doi.org/10.1007/978-94-007-7864-1_101-1


Expansion of Targeted Hydrophobic Compounds Using a Modifier

As previously described, SC–CO 2 is a suitable medium to extract hydrophobic compounds. On the other hand, complex lipids (e.g., phospholipids, PLs, and glycolipids, GLs) have higher polarity than neutral lipids (e.g., TAG), because they have a hydrophilic head groups (i.e., phosphate groups or sugars). Therefore, extraction efficiencies of complex lipids are lower than that of neutral lipids by SFE with SC–CO 2. However, the polarity of SC–CO 2can be changed considerably by adding a polar organic solvent such as methanol, ethanol, etc., as a modifier. Thus, in recent years, many SFE applications using greener and less toxic...
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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Hiroaki Takeda
    • 1
  • Yoshihiro Izumi
    • 1
  • Takeshi Bamba
    • 1
  1. 1.Division of Metabolomics, Medical Institute of BioregulationKyushu UniversityFukuokaJapan