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Use of Bone Biomarkers After Weight Loss: Example of Bariatric Surgery

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Biomarkers in Bone Disease

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Abstract

The prevalence of obesity has increased around the world, and the frequency of bariatric surgery, one of the therapeutic alternatives for specific cases, has also increased progressively. Despite the beneficial effects of bariatric surgery on various obesity-related comorbidities, the most significant postoperative weight losses have been associated with negative skeletal repercussions. In this context, serum bone health markers could provide early warning to the higher skeletal risk. In this chapter we will discuss the mechanisms involved in the relationship between obesity, its treatment with bariatric surgery, and bone metabolism, in addition to how changes in this relationship influence the main bone biomarkers.

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Abbreviations

ALP:

Total alkaline phosphatase

BSAP:

Bone-specific alkaline phosphatase

BMD:

Bone mineral density

BMI:

Body mass index

BMP:

Bone morphogenetic proteins

BTM:

Bone turnover markers

CTX:

Collagen-type I C-telopeptide

DAN:

Differential screening-selected gene aberrative in neuroblastoma

ICTP:

Carboxy-terminal telopeptide of type I collagen

IGF-1:

Insulin growth factor 1

LRP5:

Low-density lipoprotein receptor-related protein 5

LRP6:

Low-density lipoprotein receptor-related protein 6

NIH:

National Institutes of Health

NTX:

Collagen-type I N-telopeptide

OPG:

Osteoprotegerin

PTH:

Parathyroid hormone

PICP:

Carboxy-terminal procollagen propeptides of collagen type I

PINP:

Procollagen type I amino-terminal propeptide

PIIINP:

Amino-terminal procollagen propeptides of collagen type III

RANK:

Receptor that activates the nuclear factor kappa B

RANKL:

RANK ligand

RYGB:

Gastroplasty with Roux-en-Y gastric bypass

TPH1:

1-Tryptophan hydroxylase

TRAP5b:

Tartrate-resistant acid phosphatase isoenzyme 5b

WHO:

World Health Organization

1,25OHD:

1,25-Hydroxy-vitamin D

25OHD:

25-Hydroxy-vitamin D

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Authors and Affiliations

  1. Internal Medicine Department, Botucatu Medical School, Unesp, Botucatu, São Paulo, 18618-970, Brazil

    Maria F. G. Biagioni, Adriana L. Mendes, Sergio A. R. Paiva & Glaucia M. F. S. Mazeto

Authors
  1. Maria F. G. Biagioni
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  2. Adriana L. Mendes
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  3. Sergio A. R. Paiva
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  4. Glaucia M. F. S. Mazeto
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Corresponding authors

Correspondence to Maria F. G. Biagioni , Adriana L. Mendes , Sergio A. R. Paiva or Glaucia M. F. S. Mazeto .

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Editors and Affiliations

  1. Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Department of Nutrition and Dietetics, Division of Diabetes and Nutritional Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom

    Victor R. Preedy

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Biagioni, M.F.G., Mendes, A.L., Paiva, S.A.R., Mazeto, G.M.F.S. (2017). Use of Bone Biomarkers After Weight Loss: Example of Bariatric Surgery. In: Patel, V., Preedy, V. (eds) Biomarkers in Bone Disease. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7693-7_8

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