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Registered Micro-Computed Tomography Data as a Four-Dimensional Imaging Biomarker of Bone Formation and Resorption

  • Annette I. Birkhold
  • Bettina M. Willie
Reference work entry
Part of the Biomarkers in Disease: Methods, Discoveries and Applications book series (BDMDA)

Abstract

There are significant clinical reasons motivating scientists to better understand how loading conditions, diseases, synthetic implants, and drug treatments affect bone formation and resorption. Changes in bone turnover have enormous impact on the quality and mechanical competence of the skeleton. Until recently, bone formation and resorption were primarily measured using biochemical markers of bone turnover or histomorphometry. However, recent advances in computed tomography allow one to follow structural changes in the cortical and trabecular bone of living animals and human patients. The aim of this chapter is to describe recently developed methods that allow the monitoring of bone modeling and remodeling processes in vivo by using registered longitudinal micro-computed tomography data, which serves as an imaging biomarker of bone formation and resorption. The chapter provides an overview of bone modeling and remodeling processes and the standard methods that have been used in the past and present to assess bone formation and resorption. Micro-computed tomography-based imaging of the bone is then discussed. A detailed description is then given of recently developed computation methods that allow monitoring of bone modeling and remodeling using registered longitudinal micro-computed tomography data as an imaging biomarker of bone formation and resorption. The chapter ends with a discussion of how these imaging-based biomarkers of formation and resorption can be used to complement and in some cases replace conventional experimental and clinical methods of monitoring bone turnover.

Keywords

Bone formation Bone resorption Remodeling Modeling Bone turnover Imaging biomarker Micro-computed tomography 

List of Abbreviations

AFR

Activation, formation, and resorption

BALP

Bone-specific alkaline phosphatase

BFR

Bone formation rate

BMU

Basic multicellular unit

BRR

Bone resorption rate

BS

Bone surface

BSP

Bone sialoprotein

BV

Bone volume

CTX

Carboxy-terminal cross-linked telopeptide of type I collagen

DPD

Deoxypyridinoline

ES

Eroded surface

EV

Eroded volume

HR-pQCT

High-resolution peripheral quantitative computed tomography

LRP5/6

Lipoprotein receptor-related protein 5 and 6

MAR

Mineral apposition rate

microCT

Micro-computed tomography

MRR

Mineral resorption rate

MS

Mineralizing surface

MV

Mineralized volume

NTX

Amino-terminal cross-linked telopeptide of type I collagen

OC

Osteocalcin

PICP

Procollagen type I C-terminal propeptide

PINP

Procollagen type I N-terminal propeptide

PYD

Pyridinoline

TRACP5b

5b isoenzyme of tartrate-resistant acid phosphatase

TRAP

Tartrate-resistant acid phosphatase

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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  1. 1.Continuum Biomechanics and Mechanobiology Research GroupInstitute of Applied Mechanics, University of StuttgartStuttgartGermany
  2. 2.Department of Pediatric Surgery, McGill UniversityResearch Centre, Shriners Hospital for Children-CanadaMontrealCanada

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