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Nuclear BMI-1 as a Biomarker in Laryngeal Cancer

  • Eugenia Allegra
  • Serena Trapasso
Reference work entry
Part of the Biomarkers in Disease: Methods, Discoveries and Applications book series

Abstract

The main cause of treatment failure and death in laryngeal squamous cell carcinoma is metastasis to the regional lymph nodes. The current clinical staging criteria fail to differentiate patients with occult metastasis from patients without metastasis. Identifying molecular markers of the disease might improve our understanding of the molecular mechanisms underlying the pathogenesis and development of laryngeal carcinoma and may help improve clinical staging and treatment.

Emerging studies show BMI1 has an important function as a biomarker of cancer stem cells (CSCs), which are cells with self-renewal characteristics and capable of initiation, progression, invasion, metastasis, tumor recurrence, and resistance to chemotherapy and radiotherapy. There are increasing studies that consider the role of CSCs in head and neck cancers and the potential result of this knowledge on clinical-surgical outcome. A promising intracellular marker of CSCs in head and neck cancer is the oncoprotein BMI1, with specific data about its prognostic value based on the specific location. More precisely, the nuclear expression of BMI1 in patients with laryngeal carcinoma seems to correlate with lymph node metastasis.

Keywords

Cancer Stem Cell Laryngeal Squamous Cell Carcinoma Laryngeal Carcinoma BMI1 Expression Laryngeal Squamous Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations

BMI1

B-Cell-Specific moloney Murine Leukemia Virus Integration site 1

BTRC

Beta-Transducin Repeat Containing

cBMI1

Cytoplasmatic B-Cell-Specific Moloney Murine Leukemia Virus Integration Site 1

CSCs

Cancer Stem Cells

EMT

Epithelial-Mesenchymal Transition

HTH

Helix-Turn-Helix

LSCC

Laryngeal Squamous Cell Carcinoma

nBMI1

Nuclear B-Cell-Specific Moloney Murine Leukemia Virus Integration Site 1

PcG

Polycomb Group

PRC1

Polycomb-Repressive Complex 1

PRC2

Polycomb-Repressive Complex 2

PSC

Posterior Sex Control

RF

Ring Finger

TERT

Telomerase Reverse Transcriptase

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Otolaryngology-Head and Neck Surgery, Department of Medical and Surgical SciencesUniversity Magna Graecia of CatanzaroCatanzaroItaly

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