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Role of Reproductive Hormones in Islet Adaptation to Metabolic Stress

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Islets of Langerhans

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Abstract

There is an interaction between reproduction and energy stores. Both the production and secretion of insulin by pancreatic islet β-cells must adapt to the metabolic demands of various environmental stresses related to reproduction and energy status. These adaptations must occur in a sex-specific manner. It is therefore conceivable that reproductive hormones play a role in β-cell adaptation to environmental stresses. This review explores the roles of estrogen, androgen, progesterone, and lactogens in pancreatic β-cell mass and function under conditions of metabolic stress such as pregnancy, obesity, and diabetes.

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Acknowledgments

This work was supported by grants from NIH RO1 DK074970, the Juvenile Diabetes Research Foundation (1-2006-837) and the March of Dimes (6-FY7-312).

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, 1430 Tulane Avenue SL53, New Orleans, LA, 70112, USA

    Ana Isabel Alvarez-Mercado & Franck Mauvais-Jarvis

  2. Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60611, USA

    Guadalupe Navarro & Franck Mauvais-Jarvis

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  1. Ana Isabel Alvarez-Mercado
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  2. Guadalupe Navarro
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  3. Franck Mauvais-Jarvis
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Correspondence to Franck Mauvais-Jarvis .

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  1. Department of Clinical Sciences and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

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Alvarez-Mercado, A.I., Navarro, G., Mauvais-Jarvis, F. (2015). Role of Reproductive Hormones in Islet Adaptation to Metabolic Stress. In: Islam, M. (eds) Islets of Langerhans. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6686-0_44

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