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Three-Dimensional Structures and Mechanisms of Snake Venom Serine Proteinases, Metalloproteinases, and Phospholipase A2s

  • M. A. Coronado
  • F. R. de Moraes
  • A. Ullah
  • R. Masood
  • V. S. Santana
  • R. Mariutti
  • H. Brognaro
  • D. Georgieva
  • M. T. Murakami
  • C. Betzel
  • R. K. Arni
Living reference work entry

Abstract

High-resolution crystal structures provide accurate information of the positions of the atoms which can be used to understand substrate specificity, secondary binding sites, and catalytic mechanisms. Detailed structural information and mechanisms of serine proteinases, metalloproteinases, and phospholipases A2s are presented.

Keywords

Disulfide Bridge Snake Venom Catalytic Triad Carbonyl Oxygen Atom Solvent Water Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • M. A. Coronado
    • 1
  • F. R. de Moraes
    • 1
  • A. Ullah
    • 1
  • R. Masood
    • 1
  • V. S. Santana
    • 1
  • R. Mariutti
    • 1
  • H. Brognaro
    • 1
  • D. Georgieva
    • 2
  • M. T. Murakami
    • 3
  • C. Betzel
    • 2
  • R. K. Arni
    • 1
  1. 1.Department of Physics, IBILCE/UNESPMulti User Center for Biomolecular InnovationSão Jose do Rio Preto-SPBrazil
  2. 2.Institute of Biochemistry and Molecular BiologyUniversity of Hamburg, Laboratory of Structural Biology of Infection and Inflammation, c/o DESYHamburgGermany
  3. 3.National Laboratory for BiosciencesNational Center for Research in Energy and MaterialsCampinasBrazil

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