Anticholinergics Syndrome Related to Plants and Herbs

Reference work entry
Part of the Toxinology book series (TOXI, volume 2)

Abstract

Anticholinergic poisoning is one of the typical toxidromes. Plant tropane alkaloids – atropine, scopolamine and hyoscyamine – are the common causes of this toxidrome when they enter the human body through GI absorption and/or skin contact. Because the toxins mimic to the essential neurotransmitter acetylcholine, they cause antagonist effects on the parasympathetic nerves with specific receptors that control mucous secretion, sweating, and heart rate. The plants that containing tropane alkaloids are Solanaceae, such as Atropa, Datura, and Mandragora, with the distribution to the individual plant and the ratio of toxins different from species to species. Although the clinical presentations may be slightly different, the antidotes of all the intoxications are physostigmine. Decontamination and supportive care may be required.

Keywords

Muscarinic Receptor Nicotinic Receptor Motion Sickness Tropane Alkaloid Lupine Seed 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Division of Toxicology, Trauma and Emergency CenterChina Medical University HospitalTaichungTaiwan
  2. 2.Graduate Institute of Clinical Medical ScienceChina Medical UniversityTaichungTaiwan
  3. 3.Faculty of Pharmacology and ToxicologyUniversity of TorontoTorontoCanada

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