Encyclopedia of Nanotechnology

Living Edition
| Editors: Bharat Bhushan

In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles

  • Meghan E. Samberg
  • Zhoumeng Lin
  • Nancy A. Monteiro-Riviere
Living reference work entry
DOI: https://doi.org/10.1007/978-94-007-6178-0_331-2



Silver nanoparticles (Ag-nps): Any shaped particle that has silver as its majority constituent and one dimension ranging from 1 to 100 nm; its surface may be modified with intricate or conjugated complexes.

Nanotechnology has enabled the incorporation of silver nanoparticles (Ag-nps) into hundreds of products used as antimicrobial agents in both professional and personal healthcare fields. The quantity of Ag-nps produced annually is rapidly increasing and fueled by the growing markets for products that incorporate them. This increased usage will lead to the accumulation of Ag-nps in the air, water, soil, and within organisms. Additionally, possible human and environmental toxicological risks associated with Ag-np exposure may arise during material fabrication, handling, usage, and waste disposal. For example, up to 100 % of the Ag-nps incorporated into socks to kill the bacteria...


Stratum Corneum PBPK Model Exposure Route Wound Dressing Oral Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Meghan E. Samberg
    • 1
  • Zhoumeng Lin
    • 2
  • Nancy A. Monteiro-Riviere
    • 3
  1. 1.Arteriocyte, Inc.ClevelandUSA
  2. 2.Institute of Computational Comparative Medicine, Department of Anatomy and PhysiologyKansas State UniversityManhattanUSA
  3. 3.Nanotechnology Innovation Center of Kansas State, Department of Anatomy and PhysiologyKansas State UniversityManhattanUSA