Structure and Stability of Protein Materials
Protein-based materials are polymeric biomaterials comprising amino acid subunits that are connected together by peptide bonds. These materials are usually biomimetic, self-assemble into higher-order nanometer-scale architectures, and can interact with biological entities. Determination of their structure and stability is an important component of assessing their utility and function.
The control of architecture at the nanoscale is a challenge in which nature has been highly successful. Since genetic manipulation enables the definition of every monomer in a polymeric protein structure, giving far greater control than conventional chemical synthesis, one approach in material synthesis is the use of protein engineering to create biologically inspired materials . By combining natural scaffolds, structural elements, and biologically reactive sites, materials with novel architectures and properties can be...