Synonyms
Definition
Synthetic biology is the design and construction of biological components (e.g., enzymes, gene circuits, and whole cells) from scratch or from standardized parts.
Overview
The term “synthetic biology” was first used in 1980 by Barbara Hobom to describe genetically engineered bacteria using recombinant DNA technology. In 2000, the term reappeared again by Eric Kool and others at the annual meeting of the American Chemical Society to refer to synthesis of unnatural chemical products (e.g., organic molecules) as an extension of synthetic chemistry [1].
Although the scope of synthetic biology has explosively expanded in the last decade, synthetic biology can be best described as “efforts to redesign life,” that is, the design and construction of biological components (e.g., enzymes, gene circuits, and whole cells) using living cells. Similar approaches have already been taken long before the advent of synthetic biology, for example, by genetic...
References
Benner, S.A., Sismour, A.M.: Synthetic biology. Nat. Rev. Genet. 6(7), 533–543 (2005)
Andrianantoandro, E., Basu, S., Karig, D.K., Weiss, R.: Synthetic biology: new engineering rules for an emerging discipline. Mol. Syst. Biol. 2(1), 2006.0028 (2006)
The BioBricks Foundation. http://bbf.openwetware.org/
Knight, T.: Idempotent vector design for standard assembly of biobricks standard biobrick sequence interface. MIT Synthetic Biology Working Group Report, MIT Artificial Intelligence Laboratory. 1–11 (2003)
Endy, D.: Foundations for engineering biology. Nature 438(7067), 449–453 (2005)
Nielsen, P.E., Egholm, M.: An introduction to peptide nucleic acid. Curr. Issues Mol. Biol. 1(1–2), 89–104 (1999)
McDaniel, R., Weiss, R.: Advances in synthetic biology: on the path from prototypes to applications. Curr. Opin. Biotechnol. 16(4), 476–483 (2005)
Hooshangi, S., Thiberge, S., Weiss, R.: Ultrasensitivity and noise propagation in a synthetic transcriptional cascade. Proc. Natl. Acad. Sci. U. S. A. 102(10), 3581–3586 (2005)
Basu, S., Mehreja, R., Thiberge, S., Chen, M.-T., Weiss, R.: Spatiotemporal control of gene expression with pulse-generating networks. Proc. Natl. Acad. Sci. U. S. A. 101(17), 6355–6360 (2004)
Becskei, A., Serrano, L.: Engineering stability in gene networks by autoregulation. Nature 405, 590–593 (2000)
Nevozhay, D., Adams, R.M., Murphy, K.F., Josic, K., Balzsi, G.: Negative autoregulation linearizes the dose–response and suppresses the heterogeneity of gene expression. Proc. Natl. Acad. Sci. U. S. A. 106(13), 5123–5128 (2009)
Gardner, T.S., Cantor, C.R., Collins, J.J.: Construction of a genetic toggle switch in Escherichia coli. Nature 403(6767), 339–342 (2000)
Judd, E.M., Laub, M.T., McAdams, H.H.: Toggles and oscillators: new genetic circuit designs. Bioessays 22(6), 507–509 (2000)
Smith, H.O., Hutchison, C.A., Pfannkoch, C., Venter, J.C.: Generating a synthetic genome by whole genome assembly: x174 bacteriophage from synthetic oligonucleotides. Proc. Natl. Acad. Sci. U. S. A. 100(26), 15440–15445 (2003)
Gibson, D.G., Glass, J.I., Lartigue, C., Noskov, V.N., Chuang, R.-Y., Algire, M.A., Benders, G.A., Montague, M.G., Ma, L., Moodie, M.M., Merryman, C., Vashee, S., Krishnakumar, R., Assad-Garcia, N., Andrews-Pfannkoch, C., Denisova, E.A., Young, L., Qi, Z.-Q., Segall-Shapiro, T.H., Calvey, C.H., Parmar, P.P., Hutchison, C.A., Smith, H.O., Venter, J.C.: Creation of a bacterial cell controlled by a chemically synthesized genome. Science 329(May), 52–56 (2010)
Forster, A.C., Church, G.M.: Towards synthesis of a minimal cell. Mol. Syst. Biol. 2(45), 45 (2006)
Luisi, P.L., Ferri, F., Stano, P.: Approaches to semi-synthetic minimal cells: a review. Naturwissenschaften 93(1), 1–13 (2006)
Theberge, A.B.., Courtois, F., Schaerli, Y., Fischlechner, M., Abell, C., Hollfelder, F., Huck, W.T.S.: Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. Angew. Chem. Int. Ed. 49(34), 5846–5868 (2010)
Synthetic Genomics Inc. Press Release http://www.syntheticgenomics.com/media/press/71409.html. Accessed 14 July 2009
ETC group report, Extreme Genetic Engineering: An Introduction to Synthetic Biology, http://www.etcgroup.org/content/extreme-genetic-engineering-introduction-synthetic-biology (2007) Accessed 7 May 2015
Khosla, C., Keasling, J.D.: Metabolic engineering for drug discovery and development. Nat. Rev. Drug Discov. 2(12), 1019–1025 (2003)
Keasling, J.: Synthetic biology for synthetic chemistry. ACS Chem. Biol. 3(1), 64–76 (2008)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media Dordrecht
About this entry
Cite this entry
Tsuda, S. (2015). Synthetic Biology. In: Bhushan, B. (eds) Encyclopedia of Nanotechnology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6178-0_139-2
Download citation
DOI: https://doi.org/10.1007/978-94-007-6178-0_139-2
Received:
Accepted:
Published:
Publisher Name: Springer, Dordrecht
Online ISBN: 978-94-007-6178-0
eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics