Surface-Enhanced Raman Scattering for Imaging Biological Cells
Nanoparticles, as a term, generally refer to any type of particle that is composed of metallic, semiconductor, or even biological material. The particles sizes that fall under the term usually range from around 1 to 100 nm in diameter. Very small size nanoparticles, where the number and arrangement of atoms are well determined, are also termed nanoclusters (e.g., a 22-atom gold nanoparticle is usually referred to as a nanocluster). In the current article, the term “nanoparticles” is used to refer to 50 nm diameter gold nanoparticles, unless otherwise noted. Surface-enhanced Raman scattering (SERS) is a term that refers to the amplification of the wavelength shift in scattered light where the shift is caused by vibrations in a sample (similar to a Doppler shift), and the amplification is caused by the presence of a surface. “Biological cells” usually refer to living cells, either in tissue or cultured on a substrate. Whether mammalian or not, cells are the building blocks of...
KeywordsGold Nanoparticles SERS Spectrum SERS Signal Plasmonic Property Intracellular Molecule
- 2.Mohr, F. (ed.): Gold Chemistry: Applications and Future Directions in the Life Sciences. Wiley-VCH, Weinheim (2009)Google Scholar
- 3.Sau, T.K., Rogach, A.L. (eds.): Complex-Shaped Metal Nanoparticles. Wiley-VCH, Weinheim (2012)Google Scholar
- 5.Chau, L.-K., Chang, H.-T.: From Bioimaging to Biosensors: Noble Metal Nanoparticles in Biodetection. Pan Stanford, Singapore (2013)Google Scholar