Synonyms
Mixture ecotoxicity; Multiple stressor ecotoxicity
Glossary
- Antagonism:
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A class of interactive joint action between compounds where the potency effects of the mixture are lower than expected, i.e., where the joint action is interactive.
- Assessment endpoint:
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Parameter measured after a test exposure on a given organism, e.g., mortality and reproduction. A measurement endpoint designates calculated values such as NOEC or EC50.
- Baseline toxicity:
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Baseline toxicity is the minimal toxicity of any given chemical. It is due to a nonspecific mode of action that exerts a narcotic toxicity. For example, the toxicity of triazines on insects or fish can be seen as baseline toxicity. Indeed triazines act as photosynthesis inhibitors, but this process has no effect on these organisms.
- Concentration addition (CA):
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The concentration addition (or dose addition) model is commonly used to predict mixture toxicity for similarly acting compounds (with a similar mode of toxic action). This concept...
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References
Altenburger R, Backhaus T, Boedecker W et al (2000) Predictability of the toxicity of multiple chemical mixtures to Vibrio fischeri: mixtures composed of similarly acting chemicals. Environ Toxicol Chem 19:2341–2347
Arrhenius A, Grönvall F, Scholze M et al (2004) Predictability of the mixture toxicity of 12 similarly acting congeneric inhibitors of photosystem II in marine periphyton and epipsammon communities. Aquat Toxicol 68:351–367
Ashford J (1981) General models for the joint action of mixtures of drugs. Biometrics 37:457–474
Backhaus T, Altenburger R, Boedecker W et al (2000) Predictability of the toxicity of multiple mixture of dissimilarly acting chemicals to Vibrio fischeri. Environ Toxicol Chem 19:2348–2356
Backhaus T, Altenburger R, Arrhenius A et al (2003) The BEAM-project: prediction and assessment of mixture toxicities in the aquatic environment. Cont Shelf Res 23:1757–1769
Belden JB, Gilliom R, Lydy MJ (2007) How well can we predict the toxicity of pesticide mixtures to aquatic life? IEAM 3:364–372
Bliss (1939) The toxicity of poisons applied jointly. Ann Appl Biol 26:412–585
Cedergreen N, Abbaspoor M et al (2007) Is mixture toxicity measured on a biomarker indicative of what happens on a population level? A study with Lemna minor. Ecotoxicol Environ Saf 67:323–332
Chèvre N, Loepfe C, Singer H et al (2006) Including mixtures in the determination of water quality criteria for herbicides in surface water. Environ Sci Technol 40:426–435
de Zwart D (2005a). Impact of toxicity on species composition of aquatic communities: concordance of predictions and field observations. PhD Thesis. University of Amsterdam, Amsterdam
de Zwart D (2005b) Ecological effects of pesticide use in the Netherlands: modeled and observed effects in the field ditch. IEAM 1:123–134
de Zwart D, Posthuma L (2005) Complex mixture toxicity for single and multiple species: proposed methodologies. Environ Toxicol Chem 24:2665–2676
Hewlett P, Plackett R (1959) A unified theory for quantal responses to mixtures of drugs: non interactive action. Biometrics 15:591–610
Junghans M, Backhaus T, Faust M et al (2006) Application and validation of approaches for the predictive hazard assessment of realistic pesticide mixtures. Aquat Toxicol 76:93–110
Knauert S, Dawo U, Hollender J et al (2009) Effects of photosystem II inhibitors and their mixture on freshwater phytoplankton succession in outdoor mesocosms. Environ Toxicol Chem 28:836–845
Könemann H (1981) Fish toxicity tests with mixtures of more than two chemicals: a proposal for a quantitative approach and experimental results. Toxicology 19:229–238
Loewe S, Muischnek H (1926) Über Kombinationswirkungen. Arch für Exp Pathol Pharmakol 114:313–326
Plackett R, Hewlett P (1952) Quantal responses to mixtures of poisons. J R Stat Soc B XIV:143–163
Posthuma L, de Zwart D (2006) Predicted effects of toxicant mixtures are confirmed by changes in fish assemblages in Ohio, USA, Rivers. Environ Toxicol Chem 25:1094–1105
Silva E, Rajapakse N, Kortenkamp A (2002) Something from “nothing” – eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environ Sci Technol 36:1751–1756
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Chèvre, N., Gregorio, V. (2013). Mixture Effects in Ecotoxicology. In: Férard, JF., Blaise, C. (eds) Encyclopedia of Aquatic Ecotoxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5704-2_67
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