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Handbook of Photonics for Biomedical Engineering pp 29–60Cite as

SERS for Sensitive Biosensing and Imaging

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Abstract

Surface-enhanced Raman scattering spectroscopy or SERS has gained wide popularity over the past two decades in the field of biomedicine due to its unique analytical capability and ease of use. This chapter provides an account of the recent developments in SERS for selected biomedical applications. Label free and labeled detection with Raman reporter schemes have been employed to detect and identify various biomolecules such as nucleic acids, lipids, peptides, and proteins, as well as for in vivo and cellular sensing. A detailed account of various SERS biosensing strategies is reviewed with emphasis on the sensitivity and specificity by elaborating some recent examples of preclinical and clinical applications. Finally, a critical analysis of the technology is provided with regard to the challenges yet to be addressed and its future trend in biomedicine.

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Author information

Authors and Affiliations

  1. Bio-Optical Imaging Group, Singapore Bioimaging Consortium (SBIC), A*STAR, 11 Biopolis Way, #02-02, Helios, 138667, Singapore, Singapore

    U. S. Dinish & Malini Olivo

  2. Bio-photonics Group, School of Physics, National University of Ireland, Galway, Ireland

    Malini Olivo

Authors
  1. U. S. Dinish
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  2. Malini Olivo
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Corresponding authors

Correspondence to U. S. Dinish or Malini Olivo .

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Editors and Affiliations

  1. Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong

    Aaron Ho-Pui Ho

  2. School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea (Republic of)

    Donghyun Kim

  3. Department of Electronic and Information Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong

    Michael G. Somekh

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Dinish, U.S., Olivo, M. (2017). SERS for Sensitive Biosensing and Imaging. In: Ho, AP., Kim, D., Somekh, M. (eds) Handbook of Photonics for Biomedical Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5052-4_24

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