Deep Brain Stimulation for Parkinson’s Disease: Historical and Neuroethical Aspects

  • Paul Foley
Reference work entry


The introduction of deep brain stimulation for movement disorders has raised concerns about the impact of therapy upon the personal identity of the patients. It is argued that, while caution is naturally advisable, these concerns have been somewhat exaggerated, and that the ethical approach to the therapy of movement aims to maximize both the motor and psychiatric benefits for the patient, as it is their personal welfare that must be placed at the center of questions of therapy and investigation. The historical development of DBS techniques as applied to the therapy of Parkinson’s disease is explored, including their status as less destructive and partially reversible successors to surgical techniques employed in the pre-l-DOPA era.


Deep Brain Stimulation Movement Disorder Essential Tremor Impulse Control Disorder Encephalitis Lethargica 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Agid, Y., Schüpbach, M., Mallet, L., Houeto, J. L., Behar, C., Maltete, D., & Welter, M. L. (2006). Neurosurgery in Parkinson’s disease: The doctor is happy, the patient less so? Journal of Neural Transmission. Supplementum, 70, 409–414.CrossRefGoogle Scholar
  2. Alvarez, L., Macias, R., Lopez, G., Alvarez, E., Pavon, N., Rodriguez-Oroz, M. C., Juncos, J. L., Maragoto, C., Guridi, J., Litvan, I., Tolosa, E. S., Koller, W., Vitek, J., DeLong, M. R., & Obeso, J. A. (2005). Bilateral subthalamotomy in Parkinson’s disease: Initial and long-term response. Brain, 128, 570–583.CrossRefGoogle Scholar
  3. Amadio, J. P., & Boulis, N. M. (2011). Practical considerations in the ethics of parkinsonian deep brain stimulation. AJOB Neuroscience, 2, 24–26.CrossRefGoogle Scholar
  4. Andrews, R. J. (2010a). Neuromodulation. Advances in the next decade. Annals of the New York Academy of Sciences, 1199, 212–220.CrossRefGoogle Scholar
  5. Andrews, R. J. (2010b). Neuromodulation. Advances in the next five years. Annals of the New York Academy of Sciences, 1199, 204–211.CrossRefGoogle Scholar
  6. Appel-Cresswell, S., & Stoessl, A. J. (2011). Ethical issues in the management of Parkinson’s disease. In J. Illes & B. J. Sahakian (Eds.), The Oxford handbook of neuroethics (pp. 575–600). Oxford: Oxford University Press.Google Scholar
  7. Ashkan, K., Samuel, M., Reddy, P., & Chaudhuri, K. R. (2013). The impact of deep brain stimulation on the nonmotor symptoms of Parkinson’s disease. Journal of Neural Transmission, 120, 639–642.CrossRefGoogle Scholar
  8. Baláž, M., Bocková, M., Bareš, M., Rektorová, I., Dírerová, V., & Rektor, I. (2011a). Kvalita života po hluboké mozkové stimulaci u pacientu s pokrocilou Parkinsonovou nemocí. Ceska a Slovenska Neurologie a Neurochirurgie, 74, 564–568.Google Scholar
  9. Baláž, M., Bočková, M., Rektorová, I., & Rektor, I. (2011b). Involvement of the subthalamic nucleus in cognitive functions – A concept. Journal of the Neurological Sciences, 310, 96–99.CrossRefGoogle Scholar
  10. Baumeister, A. (2000). The Tulane electrical brain stimulation program. A historical case study in medical ethics. Journal of the History of the Neurosciences, 9, 262–278.CrossRefGoogle Scholar
  11. Baylis, F. (2011). “I am who I am”: On the perceived threats to personal identity from deep brain stimulation. Neuroethics, 14 pp. doi:10.1007/s12152-011-9137-1.Google Scholar
  12. Bell, E., Maxwell, B., McAndrews, M. P., Sadikot, A., & Racine, E. (2011a). Deep brain stimulation and ethics: Perspectives from a multisite qualitative study of Canadian neurosurgical centers. World Neurosurgery, 76, 537–547.CrossRefGoogle Scholar
  13. Bell, E., Maxwell, B., McAndrews, M. P., Sadikot, A. F., & Racine, E. (2011b). A review of social and relational aspects of deep brain stimulation in Parkinson’s disease informed by healthcare provider experiences. Parkinsons Disease, 8 pp. ID 871874.Google Scholar
  14. Benabid, A. L., Pollak, P., Gervason, C., Hoffmann, D., Gao, D. M., Hommel, M., Perret, J. E., & de Rougemont, J. (1991). Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet Neurology, 337, 403–406.CrossRefGoogle Scholar
  15. Benabid, A. L., Pollak, P., Seigneuret, E., Hoffmann, D., Gay, E., & Perret, J. (1993). Chronic VIM thalamic stimulation in Parkinson’s disease, essential tremor and extra-pyramidal dyskinesias. Acta Neurochirurgica. Supplementum, 58, 39–44.Google Scholar
  16. Benabid, A. L., Pollak, P., Gao, D., Hoffmann, D., Limousin, P., Gay, E., Payen, I., & Benazzouz, A. (1996). Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. Journal of Neurosurgery, 84, 203–214.CrossRefGoogle Scholar
  17. Benabid, A. L., Chabardes, S., Torres, N., Piallat, B., Krack, P., Fraix, V., & Pollak, P. (2009). Functional neurosurgery for movement disorders: A historical perspective. Progress in Brain Research, 175, 379–391.CrossRefGoogle Scholar
  18. Bergman, H., Wichmann, T., & DeLong, M. R. (1990). Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science, 249, 1436–1438.CrossRefGoogle Scholar
  19. Blomstedt, P., & Hariz, M. I. (2010). Deep brain stimulation for movement disorders before DBS for movement disorders. Parkinsonism & Related Disorders, 16, 429–433.CrossRefGoogle Scholar
  20. Broen, M., Duits, A., Visser-Vandewalle, V., Temel, Y., & Winogrodzka, A. (2011). Impulse control and related disorders in Parkinson’s disease patients treated with bilateral subthalamic nucleus stimulation: A review. Parkinsonism & Related Disorders, 17, 413–417.CrossRefGoogle Scholar
  21. Bronstein, J. M., Tagliati, M., Alterman, R. L., Lozano, A. M., Volkmann, J., Stefani, A., Horak, F. B., Okun, M. S., Foote, K. D., Krack, P., Pahwa, R., Henderson, J. M., Hariz, M. I., Bakay, R. A., Rezai, A., Marks, W. J., Moro, E., Vitek, J. L., Weaver, F. M., Gross, R. E., & DeLong, M. R. (2011). Deep brain stimulation for Parkinson disease. An expert consensus and review of key issues. Archives of Neurology, 68, 165–171.CrossRefGoogle Scholar
  22. Burdick, A. P., Foote, K. D., Wu, S., Bowers, D., Zeilman, P., Jacobson, C. E., Ward, H. E., & Okun, M. S. (2011). Do patient’s [sic] get angrier following STN, GPi, and thalamic deep brain stimulation. NeuroImage, 54(Suppl. 1), S227–S232.CrossRefGoogle Scholar
  23. Clausen, J. (2010). Ethical brain stimulation – Neuroethics of deep brain stimulation in research and clinical practice. European Journal of Neuroscience, 32, 1152–1162.CrossRefGoogle Scholar
  24. Clausen, J. (2011). Conceptual and ethical issues with brain-hardware interfaces. Current Opinion in Psychiatry, 24, 495–501.Google Scholar
  25. Cooper, I. S. (1961). Parkinsonism. Its medical and surgical therapy. Springfield, IL: Charles C. Thomas.Google Scholar
  26. Dams, J., Bornschein, B., Reese, J. P., Conrads-Frank, A., Oertel, W. H., Siebert, U., & Dodel, R. (2011). Modelling the cost effectiveness of treatments for Parkinson’s disease: A methodological review. PharmacoEconomics, 29, 1025–1049.CrossRefGoogle Scholar
  27. Defer, G.-L., Widner, H., Marié, R.-M., Rémy, P., Levivier, M., and the conference participants. (1999). Core assessment program for surgical interventional therapies in Parkinson’s disease (CAPSIT-PD). Movement Disorders, 14, 572–584.Google Scholar
  28. Dörr, D. (2010). Einfluss der Tiefen Hirnstimulation auf die Lebensqualität von Parkinson-Patienten. In D. Groß, G. Gründer, & V. Simonovic (Eds.) Akzeptanz, Nutzungsbarrieren und ethische Implikationen neuer Medizintechnologien. Die Anwendungsfelder Telemedizin und Inkorporierte Technik. Proceedings-Band (pp. 133–136). Studien des Aachener Kompetenzzentrums für Wissenschaftsgeschichte, 8. Kassel: Kassel University Press.Google Scholar
  29. Dubiel, H. (2009). Deep in the brain (trans. P. Schmitz). New York: Europa Editions.Google Scholar
  30. Fasano, A., Romito, L. M., Daniele, A., Piano, C., Zinno, M., Bentivoglio, A. R., & Albanese, A. (2010). Motor and cognitive outcome in patients with Parkinson’s disease 8 years after subthalamic implants. Brain, 133, 2664–2676.CrossRefGoogle Scholar
  31. Fins, J. J. (2009). Deep brain stimulation, deontology and duty: The moral obligation of non-abandonment at the neural interface. Journal of Neural Engineering, 6, 050201 (4 pp.).CrossRefGoogle Scholar
  32. Fins, J. J., Schlaepfer, T. E., Nuttin, B., Kubu, C. S., Galert, T., Sturm, V., Merkel, R., & Mayberg, H. S. (2011). Ethical guidance for the management of conflicts of interest for researchers, engineers and clinicians engaged in the development of therapeutic deep brain stimulation. Journal of Neural Engineering, 8, 033001 (6 pp.).CrossRefGoogle Scholar
  33. Fleck, U. (1933). Über Selbstmorde und Selbstmordversuche bei Postencephalitikern mit Bemerkungen über die Persönlichkeitsänderung der erwachsenen parkinsonistischen Postencephalitiker. Archiv für Psychiatrie und Nervenkrankheiten, 99, 233–300.CrossRefGoogle Scholar
  34. Foley, P. (2012). The encephalitis lethargica patient as a window on the soul. In L. S. Jacyna & S. T. Casper (Eds.), The neurological patient in history (pp. 184–211). Rochester, NY: University of Rochester Press.CrossRefGoogle Scholar
  35. Frank, M. J., Samanta, J., Moustafa, A. A., & Sherman, S. J. (2007). Hold your horses: Impulsivity, deep brain stimulation, and medication in parkinsonism. Science, 318, 1309–1312.CrossRefGoogle Scholar
  36. Franzini, A., Cordella, R., Messina, G., Marras, C. E., Romito, L. M., Carella, F., Albanese, A., Rizzi, M., Nardocci, N., Zorzi, G., Zekay, E., & Broggi, G. (2011). Deep brain stimulation for movement disorders. Considerations on 276 consecutive patients. Journal of Neural Transmission, 118, 1497–1510.CrossRefGoogle Scholar
  37. Giacino, J., Fins, J. J., Machado, A., & Schiff, N. D. (2012). Central thalamic deep brain stimulation to promote recovery from chronic posttraumatic minimally conscious state: Challenges and opportunities. Neuromodulation, 15, 339–349.CrossRefGoogle Scholar
  38. Gilbert, F. (2012). The burden of normality: From ‘chronically ill’ to ‘symptom free’. New ethical challenges for deep brain stimulation postoperative treatment. Journal of Medical Ethics, 38, 408–412.CrossRefGoogle Scholar
  39. Gilbert, F., & Ovadia, D. (2011). Deep brain stimulation in the media: Over-optimistic portrayals call for a new strategy involving journalists and scientists in ethical debates. Frontiers in Integrative Neuroscience, 5, 16 (6 pp.).CrossRefGoogle Scholar
  40. Gisquet, E. (2008). Cerebral implants and Parkinson’s disease: A unique form of biographical disruption? Social Science & Medicine, 67, 1847–1851.CrossRefGoogle Scholar
  41. Glannon, W. (2009). Stimulating brains, altering minds. Journal of Medical Ethics, 35, 289–292.CrossRefGoogle Scholar
  42. Glannon, W. (2010). Consent to deep brain stimulation for neurological and psychiatric disorders. Journal of Clinical Ethics, 21, 104–111.Google Scholar
  43. Goethals, I., Jacobs, F., Van der Linden, C., Caemaert, J., & Audenaert, K. (2008). Brain activation associated with deep brain stimulation causing dissociation in a patient with Tourette’s syndrome. Journal of Trauma & Dissociation, 9, 543–549.CrossRefGoogle Scholar
  44. Haahr, A., Kirkevold, M., Hall, E. O. C., & Østergaard, K. (2013). ‘Being in it together’: Living with a partner receiving deep brain stimulation for advanced Parkinson’s disease – A hermeneutic phenomenological study. Journal of Advanced Nursing, 69, 338–347.CrossRefGoogle Scholar
  45. Hälbig, T. D. (2010). Manipulating the brain. An ethical challenge? Lessons from deep brain stimulation in movement disorders. In H. Fangerau, J. M. Fegert, & T. Trapp (Eds.), Implanted minds. The neuroethics of intracerebral stem cell transplantation and deep brain stimulation (pp. 251–280). Bielefeld: Transcript.Google Scholar
  46. Hariz, M. I. (2003). From functional neurosurgery to “interventional” neurology: Survey of publications on thalamotomy, pallidotomy, and deep brain stimulation for Parkinson’s disease from 1966 to 2001. Movement Disorders, 18, 845–852.CrossRefGoogle Scholar
  47. Hariz, M. (2012). Twenty-five years of deep brain stimulation: Celebrations and apprehensions. Movement Disorders, 27, 930–933.CrossRefGoogle Scholar
  48. Hariz, M. I., Blomstedt, P., & Zrinzo, L. (2010). Deep brain stimulation between 1947 and 1987: The untold story. Neurosurgical Focus, 29, E1 (10 pp.).CrossRefGoogle Scholar
  49. Hariz, G.-M., Limousin, P., Tisch, S., Jahanshahi, M., & Fjellman-Wiklund, A. (2011). Patients’ perceptions of life shift after deep brain stimulation for primary dystonia – A qualitative study. Movement Disorders, 26, 2101–2106.CrossRefGoogle Scholar
  50. Hassler, R., & Riechert, T. (1954). Indikationen and Lokalizationensmethode der Hirnoperationen. Nervenarzt, 25, 441–447.Google Scholar
  51. Holtzheimer, P. E., & Mayberg, H. S. (2011). Deep brain stimulation for psychiatric disorders. Annual Review of Neuroscience, 34, 289–307.CrossRefGoogle Scholar
  52. Jabre, M. G., & Bejjani, B.-P. W. (2007). Neurosurgery in Parkinson disease: A distressed mind in a repaired body? [letter]. Neurology, 68, 1164.CrossRefGoogle Scholar
  53. Jankovic, J., & Poewe, W. (2012). Therapies in Parkinson’s disease. Current Opinion in Neurology, 25, 433–447.CrossRefGoogle Scholar
  54. Jellinger, K. A. (2012). Neurobiology of cognitive impairment in Parkinson’s disease. Expert Review of Neurotherapeutics, 12, 1451–1466.CrossRefGoogle Scholar
  55. Kahn, E., D’Haese, P.-F., Dawant, B., Allen, L., Kao, C., Charles, P. D., & Konrad, P. (2012). Deep brain stimulation in early stage Parkinson’s disease: Operative experience from a prospective, randomized clinical trial. Journal of Neurology, Neurosurgery, and Psychiatry, 83, 164–170.CrossRefGoogle Scholar
  56. Klaming, L., & Haselager, P. (2010). Did my brain implant make me do it? Questions raised by DBS regarding psychological continuity, responsibility for action and mental competence. Neuroethics doi:10.1007/s12152-010-9093-1 (13pp).Google Scholar
  57. Kraemer, F. (2011). Me, myself and my brain implant: Deep brain stimulation raises questions of personal authenticity and alienation. Neuroethics. doi:10.1007/s12152-011-9115-7 (15pp).Google Scholar
  58. Krauss, J. K., & Grossman, R. (2002). Surgery for Parkinson’s disease and hyperkinetivc movement disorders. In J. J. Jankovic & E. Tolosa (Eds.), Parkinson’s disease and movement disorders (pp. 640–662). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  59. Krug, H. (2012). Das Unzufriedenheitsparadox in der Therapie mit tiefer Hirnstimulation. Nervenheilkunde, 31, 215–219.Google Scholar
  60. Krug, H., Müller, O., & Bittner, U. (2010). Technisierung des Ich? Überlegungen zu einer ethischen Beurteilung der tiefen Hirnstimulation unter Verwendung von Patienten-Narrationen. Fortschritte der Neurologie Psychiatrie, 78, 644–651.CrossRefGoogle Scholar
  61. Laryionava, K., Kreucher, S., Simonovic, V., & Groß, D. (2010a). Einstellung zur Tiefen Hirnstimulation unter Medizinstudierenden. In D. Groß, G. Gründer, & V. Simonovic (Eds.), Akzeptanz, Nutzungsbarrieren und ethische Implikationen neuer Medizintechnologien. Die Anwendungsfelder Telemedizin und Inkorporierte Technik. Proceedings-Band (Studien des Aachener Kompetenzzentrums für Wissenschaftsgeschichte, Vol. 8, pp. 111–116). Kassel: Kassel University Press.Google Scholar
  62. Laryionava, K., Simonovic, V., & Groß, D. (2010b). Tiefe Hirnstimulation im Spiegel der deutschen Laienpresse. In D. Groß, G. Gründer, & V. Simonovic (Eds.), Akzeptanz, Nutzungsbarrieren und ethische Implikationen neuer Medizintechnologien. Die Anwendungsfelder Telemedizin und Inkorporierte Technik. Proceedings-Band (Studien des Aachener Kompetenzzentrums für Wissenschaftsgeschichte, Vol. 8, pp. 97–103). Kassel: Kassel University Press.Google Scholar
  63. Leentjens, A. F. G., Visser-Vandewalle, V., Temel, Y., & Herhey, F. R. J. (2004). Manipuleerbare wilsbekwaamheid: een ethisch probleem bij elektrostimulatie van de nucleus subthalamicus voor ernstige ziekte van Parkinson. Nederlands Tijdschrift voor Geneeskunde, 148, 1394–1398.Google Scholar
  64. Lhommée, E., Klinger, H., Thobois, S., Schmitt, E., Ardouin, C., Bichon, A., Kistner, A., Fraix, V., Xie, J., Kombo, M. A., Chabardès, S., Seigneuret, E., Benabid, A.-L., Mertens, P., Polo, G., Carnicella, S., Quesada, J.-L., Bosson, J.-L., Broussolle, E., Pollak, P., & Krack, P. (2012). Subthalamic stimulation in Parkinson’s disease: Restoring the balance of motivated behaviours. Brain, 135, 1463–1477.CrossRefGoogle Scholar
  65. Lilly, J. C. (1957). Report on conference on the use of depth electrodes in human atients. In Annual report of program activities. National Institutes of Health. 1957. National Institute of Mental Health (pp. 258–259). Washington, DC: National Institutes of Health; Public Health Service; U.S. Department of Health, Education, and Welfare.Google Scholar
  66. Lyons, M. K. (2011). Deep brain stimulation: Current and future clinical applications. Mayo Clinic Proceedings, 86, 662–672.CrossRefGoogle Scholar
  67. Mackenzie, R. (2011). Must family/carers look after strangers? Post-DBS identity changes and related conflicts of interest. Frontiers in Integrative Neuroscience, 5, 12 (2 pp).Google Scholar
  68. Mallet, L., Schüpbach, M., N’Diaye, K., Remy, P., Bardinet, E., Czernecki, V., Welter, M.-L., Pelissolo, A., Ruberg, M., Agid, Y., & Yelnik, J. (2007). Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior. PNAS, 104, 10661–10666.CrossRefGoogle Scholar
  69. Mathews, D. J. H., Bok, H., & Rabins, P. V. (2009). Personal identity and fractured selve. Perspectives from philosophy, ethics, and neuroscience. Baltimore: Johns Hopkins University.Google Scholar
  70. McIntosh, E. S. (2011). Perspective on the economic evaluation of deep brain stimulation. Frontiers in Integrative Neuroscience, 5, 19 (7 pp).Google Scholar
  71. Merkel, R., Boer, G., Fegert, J., Galert, T., Hartmann, D., Nuttin, B., & Rosahl, S. (2007). Intervening in the brain. Changing psyche and society. Ethics of science and technology assessment (Vol. 29). Berlin/Heidelberg: Springer.Google Scholar
  72. Meyers, R. (1942). The modification of alternating tremors, rigidity and festination by surgery of the basal ganglia. In T. J. Putnam (Ed.), The diseases of the basal ganglia. Proceedings of the Association, December 20 and 21, 1940, New York (Association for Research in Nervous and Mental Disease, Vol. 21, pp. 602–665). New York: Hafner Publishing Company.Google Scholar
  73. Miocinovic, S., Somayajula, S., Chitnis, S., & Vitek, J. L. (2013). History, applications, and mechanisms of deep brain stimulation. JAMA Neurology, 70, 163–171.CrossRefGoogle Scholar
  74. Morgante, L., Morgante, F., Moro, E., Epifanio, A., Girlanda, P., Ragonese, P., Antonini, A., Barone, P., Bonuccelli, U., Contarino, M. F., Capus, L., Ceravolo, M. G., Marconi, R., Ceravolo, R., D’Amelio, M., & Savettieri, G. (2007). How many parkinsonian patients are suitable candidates for deep brain stimulation of subthalamic nucleus? Results of a questionnaire. Parkinsonism & Related Disorders, 13, 528–531.CrossRefGoogle Scholar
  75. Müller, S. (2010). Personality changes through deep brain stimulation of the subthalamic nucleus in parkinsonian patients – An ethical discussion. In H. Fangerau, J. Fegert, & T. Trapp (Eds.), Implanted minds. The neuroethics of intracerebral stem cell transplantation and deep brain stimulation (pp. 223–250). Bielefeld: Transcript.Google Scholar
  76. Müller, S., & Christen, M. (2011). Deep brain stimulation in parkinsonian patients – Ethical evaluation of cognitive, affective, and behavioral sequelae. AJOB Neuroscience, 2, 3–13.CrossRefGoogle Scholar
  77. Müller, O., Bittner, U., & Krug, H. (2010). Narrative Identität bei Therapie mit “Hirnschrittmacher”. Zur Integration von Patienten-Selbstbeschreibungen in die ethische Bewertung der tiefen Hirnstimulation. Ethik in der Medizin, 22, 303–315.CrossRefGoogle Scholar
  78. Nazzaro, J. M., Pahwa, R., & Lyons, K. E. (2011). The impact of bilateral subthalamic stimulation on non-motor symptoms of Parkinson’s disease. Parkinsonism & Related Disorders, 17, 606–609.CrossRefGoogle Scholar
  79. Odekerken, V. J. J., van Laar, T., Staal, M. J., Mosch, A., Hoffmann, C. F. E., Nijssen, P. C. G., Beute, G. N., van Vugt, J. P. P., Lenders, M. W. P. M., Contarino, M. F., Mink, M. S. J., Bour, L. J., van den Munckhof, P., Schmand, B. A., de Haan, R. J., Schuurman, P. R., & de Bie, R. M. A. (2013). Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease (NSTAPS study): A randomised controlled trial. Lancet Neurology, 12, 37–44.CrossRefGoogle Scholar
  80. Pacholczyk, A. (2011). DBS makes you feel good! Why some of the ethical objections to the use of DBS for neuropsychiatric disorders and enhancement are not convincing. Frontiers in Integrative Neuroscience, 5, 1 (2 pp.).CrossRefGoogle Scholar
  81. Parent, A. (1990). Extrinsic connections of the basal ganglia. Trends in Neuroscience, 13, 254–258.CrossRefGoogle Scholar
  82. Péron, J., & Dondaine, T. (2012). Émotion et noyaux gris centraux (II): Que peut-nous apprendre le modèle de la stimulation cérébrale profonde du noyau subthalamique dans la maladie de Parkinson? Revue Neurologique, 168, 642–648.CrossRefGoogle Scholar
  83. Raja, M., & Bentivoglio, A. R. (2012). Impulsive and compulsive behaviors during dopamine replacement treatment in Parkinson’s disease and other disorders. Current Drug Safety, 7, 63–75.CrossRefGoogle Scholar
  84. Redfern, R. M. (1989). History of stereotactic surgery for Parkinson’s disease. British Journal of Neurosurgery, 3, 271–304.CrossRefGoogle Scholar
  85. Samuel, G. N., & Brosnan, C. (2011). Deep brain stimulation for Parkinson’s disease: A critique of principlism as a framework for the ethical analysis of the decision-making process. AJOB Neuroscience, 2, 20–22.CrossRefGoogle Scholar
  86. Schermer, M. (2011). Ethical issues in deep brain stimulation. Frontiers in Integrative Neuroscience, 5, 17 (5 pp.).CrossRefGoogle Scholar
  87. Schmitz-Luhn, B., Katzenmeier, C., & Woopen, C. (2012). Law and ethics of deep brain stimulation. International Journal of Law and Psychiatry, 35, 130–136.CrossRefGoogle Scholar
  88. Schuepbach, W. M. M., Rau, J., Knudsen, K., Volkmann, J., Krack, P., Timmermann, L., Hälbig, T. D., Hesekamp, H., Navarro, S. M., Meier, N., Falk, D., Mehdorn, M., Paschen, S., Maarouf, M., Barbe, M. T., Fink, G. R., Kupsch, A., Gruber, D., Schneider, G.-H., Seigneuret, E., Kistner, A., Chaynes, P., Ory-Magne, F., Courbon, C. B., Vesper, J., Schnitzler, A., Wojtecki, L., Houeto, J.-L., Bataille, B., Maltête, D., Damier, P., Raoul, S., Sixel-Doering, F., Hellwig, D., Gharabaghi, A., Krüger, R., Pinsker, M. O., Amtage, F., Régis, J.-M., Witjas, T., Thobois, S., Mertens, P., Kloss, M., Hartmann, A., Oertel, W. H., Post, B., Speelman, H., Agid, Y., Schade-Brittinger, C., Deuschl, G., & the EARLYSTIM Study Group. (2013). Neurostimulation for Parkinson’s disease with early motor complications. New England Journal of Medicine, 368, 610–622.CrossRefGoogle Scholar
  89. Schüpbach, M., Gargiulo, M., Welter, M. L., Mallet, L., Béhar, C., Houeto, J. L., Maltête, D., Mesnage, V., & Agid, Y. (2006). Neurosurgery in Parkinson disease: A distressed mind in a repaired body? Neurology, 66, 1811–1816.CrossRefGoogle Scholar
  90. Sen, A. N., Campbell, P. G., Yadla, S., Jallo, J., & Sharan, A. D. (2010). Deep brain stimulation in the management of disorders of consciousness: A review of physiology, previous reports, and ethical considerations. Neurosurgical Focus, 29, E14 (6 pp.).CrossRefGoogle Scholar
  91. Shotbolt, P., Moriarty, J., Costello, A., Jha, A., David, A., Ashkan, K., & Samuel, M. (2012). Relationships between deep brain stimulation and impulse control disorders in Parkinson’s disease, with a literature review. Parkinsonism & Related Disorders, 181, 10–16.CrossRefGoogle Scholar
  92. Sliwa, J., & Benoist, E. (2011). Wireless sensor and actor networks: E-Health, e-Science, e-Decisions. In International conference on selected topics in mobile and wireless networking, iCOST 2011: 6085829 (6 pp).Google Scholar
  93. Smeding, H. M. M., Speelman, J. D., Huizenga, H. M., Schuurman, P. R., & Schmand, B. (2011). Predictors of cognitive and psychosocial outcome after STN DBS in Parkinson’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 82, 754–760.CrossRefGoogle Scholar
  94. Spieles-Engemann, A. L., Behbehani, M. M., Collier, T. J., Wohlgenant, S. L., Steece-Collier, K., Paumier, K., Daley, B. F., Gombash, S., Madhavan, L., Mandybur, G. T., Lipton, J. W., Terpstra, B. T., & Sortwell, C. E. (2010). Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss. Neurobiology of Disease, 39, 105–115.CrossRefGoogle Scholar
  95. Stahnisch, F. (2008). Über Forschungsentwicklungen der Neurostimulation nach 1945: Historische und ethische Aspekte medizinischer Manipulationen am menschlichen Gehirn. Würzburger medizinhistorische Mitteilungen, 27, 307–346.Google Scholar
  96. Synofzik, M., & Schlaepfer, T. E. (2008). Stimulating personality: Ethical criteria for deep brain stimulation in psychiatric patients and for enhancement purposes. Biotechnology Journal, 3, 1511–1520.CrossRefGoogle Scholar
  97. Synofzik, M., & Schlaepfer, T. E. (2011). Electrodes in the braind. Ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders. Brain Stimulation, 4, 7–16.CrossRefGoogle Scholar
  98. Synofzik, M., Schlaepfer, T. E., & Fins, J. J. (2012). How happy is too happy? Euphoria, neuroethics, and deep brain stimulation of the nucleus accumbens. AJOB Neuroscience, 3, 30–36.CrossRefGoogle Scholar
  99. Toft, M., & Dietrichs, E. (2013, in press). Medication costs following subthalamic nucleus deep brain stimulation for Parkinson’s disease [letter]. Movement Disorders. doi:10.1002/mds.25504.Google Scholar
  100. Valldeoriola, F., Morsi, O., Tolosa, E., Rumià, J., Martí, M. J., & Martínez-Martín, P. (2007). Prospective comparative study on cost-effectiveness of subthalamic stimulation and best medical treatment in advanced Parkinson’s disease. Movement Disorders, 22, 2183–2191.CrossRefGoogle Scholar
  101. Voges, J., Koulousakis, A., & Sturm, V. (2007). Deep brain stimulation for Parkinson’s disease. Acta Neurochirurgica. Supplement, 97, 171–184.CrossRefGoogle Scholar
  102. Voon, V., Krack, P., Lang, A. E., Lozano, A. M., Dujardin, K., Schüpbach, M., D’Ambrosia, J., Thobois, S., Tamma, F., Herzog, J., Speelman, J. D., Samanta, J., Kubu, C., Rossignol, H., Poon, Y.-Y., Saint-Cyr, J. A., Ardouin, C., & Moro, E. (2008). A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson’s disease. Brain, 131, 2720–2728.CrossRefGoogle Scholar
  103. Weaver, F. M., Follett, K., Stern, M., Hur, K., Harris, C., Marks, W. J., Rothlind, J., Sagher, O., Reda, D., Moy, C. S., Pahwa, R., Burchiel, K., Hogarth, P., Lai, E. C., Duda, J. E., Holloway, K., Samii, A., Horn, S., Bronstein, J., Stoner, G., Heemskerk, J., & Huang, G. D. (2009). Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: A randomized controlled trial. Journal of the American Medical Association, 301, 63–73.CrossRefGoogle Scholar
  104. Weaver, F. M., Follett, K. A., Stern, M., Luo, P., Harris, C. L., Hur, K., Marks, W. J., Rothlind, J., Sagher, O., Moy, C., Pahwa, R., Burchiel, K., Hogarth, P., Lai, E. C., Duda, J. E., Holloway, K., Samii, A., Horn, S., Bronstein, J. M., Stoner, G., Starr, P. A., Simpson, R., Baltuch, G., De Salles, A., Huang, G. D., Reda, D. J., & CSP 468 Study Group. (2012). Randomized trial of deep brain stimulation for Parkinson disease: Thirty-six-month outcomes. Neurology, 79, 55–65.CrossRefGoogle Scholar
  105. Wichmann, T., & Delong, M. R. (2011). Deep-brain stimulation for basal ganglia disorders. Basal Ganglia, 1, 65–77.CrossRefGoogle Scholar
  106. Williams, R. (2010). Alim-Louis Benabid: Stimulation and serendipity. Lancet Neurology, 9, 1152.CrossRefGoogle Scholar
  107. Williams, A. E., Arzola, G. M., Strutt, A. M., Simpson, R., Jankovic, J., & York, M. K. (2011). Cognitive outcome and reliable change indices two years following bilateral subthalamic nucleus deep brain stimulation. Parkinsonism & Related Disorders, 17, 321–327.CrossRefGoogle Scholar
  108. Wilson, C. J., Beverlin, B., & Netoff, T. (2011). Chaotic desynchronization as the therapeutic mechanism of deep brain stimulation. Frontiers in Integrative Neuroscience, 5, 50 (11 pp.).Google Scholar
  109. Witt, K. (2013). Das Identitätsproblem der tiefen Hirnstimulation und einige seiner praktischen Implikationen. Ethik in der Medizin, 25, 5–18.CrossRefGoogle Scholar
  110. Witt, K., Daniels, C., Reiff, J., Krack, P., Volkmann, J., Pinsker, M. O., Krause, M., Tronnier, V., Kloss, M., Schnitzler, A., Wojtecki, L., Botzel, K., Danek, A., Hilker, R., Sturm, V., Kupsch, A., Karner, E., & Deuschl, G. (2008). Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson’s disease: A randomised, multicentre study. Lancet Neurology, 7, 605–614.CrossRefGoogle Scholar
  111. Witt, K., Kuhn, J., Timmermann, L., Zurowski, M., & Woopen, C. (2011). Deep brain stimulation and the search for identity. Neuroethics. doi:10.1007/s12152-011-9100-1 (13 pp).Google Scholar
  112. Yamamoto, T., Katayama, Y., Obuchi, T., Kobayashi, K., Oshima, H., & Fukaya, C. (2013). Deep brain stimulation and spinal cord stimulation for vegetative state and minimally conscious state. World Neurosurgery. 80, S30.e1-e9.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Neuroscience Research AustraliaSydneyAustralia
  2. 2.Unit for History and Philosophy of ScienceUniversity of SydneySydneyAustralia

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