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Human Cerebellum in Motivation and Emotion

  • Dennis J. L. G. Schutter

Abstract

There is growing evidence which suggests that the cerebellum is implicated in processes related to motivation and emotion and in the regulation of these processes.

The evidence incorporates the notion of the tight link between motivation, emotion, and action as well as the rich connections of the cerebellum with the limbic system and cerebral cortex. In addition, functional neuroimaging studies have shown robust activation of the cerebellum during the processing of emotionally laden stimuli. Damage to cerebellar structures can lead to marked personality changes, emotion dysregulation and blunting of affect and structural abnormalities of the cerebellum have been reported in several psychopathological conditions. Invasive and noninvasive brain stimulation studies have further substantiated the proposed cerebellum-emotion link by providing direct evidence in controlled experiments. Current models built upon the idea that the cerebellum may work as a monitoring system integrating different aspects of limbic and cortical information processing and provides feedback to these brain areas to direct behavior. In spite of the available evidence the mechanism by which the human cerebellum contributes to processes related to motivation and emotion remain elusive and warrants further research.

Keywords

Autism Spectrum Disorder Transcranial Magnetic Stimulation Cerebellar Hemisphere Deep Cerebellar Nucleus Emotional Facial Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

This work was supported by an Innovational Research Grant (452-07-012) from the Netherlands Organization for Scientific Research (NWO). Author reports no conflict of interest.

References

  1. Andreasen NC (1999) A unitary model of schizophrenia. Arch Gen Psychiatry 56:781–787PubMedCrossRefGoogle Scholar
  2. Baillieux H, De Smet HJ, Paquier PF, De Deyn PP, Mariën P (2008) Cerebellar neurocognition: insights into the bottom of the brain. Clin Neurol Neurosurg 110:763–773PubMedCrossRefGoogle Scholar
  3. Bandler R, Keay KA, Floyd N, Price J (2000) Central circuits mediating patterned autonomic activity during active versus passive emotional coping. Brain Res Bull 53:95–104PubMedCrossRefGoogle Scholar
  4. Berquin PC, Gliedd JN, Jacobsen LK, Hamburger SD, Krain AL, Rapoport JL et al (1998) Cerebellum in attention-deficit hyperactivity disorder: a morphometric MRI study. Neurology 50:1087–1093PubMedCrossRefGoogle Scholar
  5. Beyer JL, Krishnan KR (2002) Volumetric brain imaging findings in mood disorders. Bipolar Disord 4:89–104PubMedCrossRefGoogle Scholar
  6. Buck R (1999) The biological affects: a typology. Psychol Rev 106:301–336PubMedCrossRefGoogle Scholar
  7. Courchesne E (1997) Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism. Curr Opin Neurobiol 7:269–278PubMedCrossRefGoogle Scholar
  8. Daskalakis ZJ, Christensen BK, Fitzgerald PB, Fountain SI, Chen R (2005) Reduced cerebellar inhibition in schizophrenia: a preliminary study. Am J Psychiatry 162:1203–1205PubMedCrossRefGoogle Scholar
  9. Desmond JE, Chen SH, Shieh PB (2005) Cerebellar transcranial magnetic stimulation impairs verbal working memory. Ann Neurol 58:553–560PubMedCrossRefGoogle Scholar
  10. Ebner TJ, Pasalar S (2008) Cerebellum predicts the future motor state. Cerebellum 7:583–588PubMedCrossRefGoogle Scholar
  11. Frijda NH (1986) The emotions. Cambridge University Press, CambridgeGoogle Scholar
  12. Gerber AJ, Posner J, Gorman D, Colibazzi T, Yu S, Wang Z et al (2008) An affective circumplex model of neural systems subserving valence, arousal, and cognitive overlay during the appraisal of emotional faces. Neuropsychologia 46:2129–2139PubMedCrossRefGoogle Scholar
  13. Gray JA, McNaughton N (2000) The neuropsychology of anxiety: an enquiry into the functions of the septo-hippocampal system. Oxford University Press, OxfordGoogle Scholar
  14. Gündel H, O'Connor MF, Littrell L, Fort C, Lane RD (2003) Functional neuroanatomy of grief: an fMRI study. Am J Psychiatry 160:1946–1953PubMedCrossRefGoogle Scholar
  15. Han S, Gao X, Humphreys GW, Ge J (2008) Neural processing of threat cues in social environments. Hum Brain Mapp 29:945–957PubMedCrossRefGoogle Scholar
  16. Heath RG (1977) Modulation of emotion with a brain pacemaker: treatment for intractable psychiatric illness. J Nerv Ment Dis 165:300–317PubMedCrossRefGoogle Scholar
  17. Heath RG, Dempesy CW, Fontana CJ, Myers WA (1978) Cerebellar stimulation: effects on septal region, hippocampus, and amygdala of cats and rats. Biol Psychiatry 13:501–529PubMedGoogle Scholar
  18. Hofer A, Siedentopf CM, Ischebeck A, Rettenbacher MA, Verius M, Felber S et al (2007) Sex differences in brain activation patterns during processing of positively and negatively valenced emotional words. Psychol Med 37:109–119PubMedCrossRefGoogle Scholar
  19. Hoppenbrouwers SS, Schutter DJLG, Fitzgerald PB, Chen R, Daskalakis ZJ (2008) The role of the cerebellum in the pathophysiology and treatment of neuropsychiatric disorders: a review. Brain Res Rev 59:185–200PubMedCrossRefGoogle Scholar
  20. Ichimiya T, Okubo Y, Suhara T, Sudo Y (2001) Reduced volume of the cerebellar vermis in neuroleptic-naive schizophrenia. Biol Psychiatry 49:20–27PubMedCrossRefGoogle Scholar
  21. Kandel ER, Schwartz JH, Jessel TM (2000) Principles of neural science, 4th edn. McGraw-Hill, New YorkGoogle Scholar
  22. Komaba Y, Osono E, Kitamura S, Katayama Y (2000) Crossed cerebellocerebral diaschisis in patients with cerebellar stroke. Acta Neurol Scand 101:8–12PubMedCrossRefGoogle Scholar
  23. Kossorotoff M, Gonin-Flambois C, Gitiaux C, Quijano S, Boddaert N, Bahi-Buisson N et al (2010) A cognitive and affective pattern in posterior fossa strokes in children: a case series. Dev Med Child Neurol 52:626–631PubMedCrossRefGoogle Scholar
  24. Levisohn L, Cronin-Golomb A, Schmahmann J (2000) Neuropsychological consequences of cerebellar tumour resection in children: cerebellar cognitive affective syndrome in a paediatric population. Brain 123:1041–1050PubMedCrossRefGoogle Scholar
  25. Lo YL, Fook-Chong S, Chan LL, Ong WY (2009) Cerebellar control of motor activation and cancellation in humans: an electrophysiological study. Cerebellum 8:302–311PubMedCrossRefGoogle Scholar
  26. Middleton FA, Strick PL (2001) Cerebellar projections to the prefrontal cortex of the primate. J Neurosci 21:700–712PubMedGoogle Scholar
  27. Mobbs D, Petrovic P, Marchant JL, Hassabis D, Weiskopf N, Seymour B, Dolan RJ, Frith CD (2007) When fear is near: threat imminence elicits prefrontal - periaqueductal gray shifts in humans. Science 317:1079–1083PubMedCrossRefGoogle Scholar
  28. Neil P, Mills NP, DelBello MP, Caleb M, Adler CM, Strakowski SM (2005) MRI analysis of cerebellar vermal abnormalities in bipolar disorder. Am J Psychiatry 162:1530–1533CrossRefGoogle Scholar
  29. O’Hearn E, Molliver ME (2001) Organizational principles of and microcircuitry of the cerebellum. Int Rev Psychiatry 13:232–246CrossRefGoogle Scholar
  30. Okugawa G, Nobuhara K, Sugimoto T, Kinoshita T (2005) Diffusion tensor imaging study of the middle cerebellar peduncles in patients with schizophrenia. Cerebellum 4:123–127PubMedCrossRefGoogle Scholar
  31. Papez JW (1937) A proposed mechanism of emotion. Arch Neurol Psychiatry 38:725–743Google Scholar
  32. Parvizi J, Anderson SW, Martin CO, Damasio H, Damasio AR (2001) Pathological laughter and crying: a link to the cerebellum. Brain 124:1708–1719PubMedCrossRefGoogle Scholar
  33. Prehn-Kristensen A, Wiesner C, Bergmann TO, Wolff S, Jansen O, Mehdorn HM et al (2009) Induction of empathy by the smell of anxiety. PLoS One 4:e5987PubMedCrossRefGoogle Scholar
  34. Sander D, Grafman J, Zalla T (2003) The human amygdala: an evolved system for relevance detection. Rev Neurosci 14:303–316PubMedCrossRefGoogle Scholar
  35. Schmahmann JD (1991) An emerging concept: the cerebellar contribution to higher function. Arch Neurol 48:1178–1187PubMedCrossRefGoogle Scholar
  36. Schmahmann JD (2000) The role of the cerebellum on affect and psychosis. J Neurolinguist 13:189–214CrossRefGoogle Scholar
  37. Schmahmann JD (2004) Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J Neuropsychiatry Clin Neurosci 16:367–378PubMedCrossRefGoogle Scholar
  38. Schmahmann JD, Sherman JC (1998) The cerebellar cognitive affective syndrome. Brain 121:561–579PubMedCrossRefGoogle Scholar
  39. Schopenhauer A (1818) The world as will and representation. Dover, New YorkGoogle Scholar
  40. Schutter DJLG, van Honk J (2005a) A framework for targeting alternative brain regions with repetitive transcranial magnetic stimulation in the treatment of depression. J Psychiatry Neurosci 30:91–97PubMedGoogle Scholar
  41. Schutter DJLG, van Honk J (2005b) The cerebellum on the rise in human emotion. Cerebellum 4:290–294PubMedCrossRefGoogle Scholar
  42. Schutter DJLG, van Honk J (2006) An electrophysiological link between the cerebellum, cognition and emotion: frontal theta EEG activity to single-pulse cerebellar TMS. Neuroimage 33:1227–1231PubMedCrossRefGoogle Scholar
  43. Schutter DJLG, van Honk J (2009) The cerebellum in emotion regulation: a transcranial magnetic stimulation study. Cerebellum 8:28–34PubMedCrossRefGoogle Scholar
  44. Schutter DJLG, van Honk J, d'Alfonso AAL, Peper JS, Panksepp J (2003) High frequency repetitive transcranial magnetic over the medial cerebellum induces a shift in the prefrontal electroencephalography gamma spectrum: a pilot study in humans. Neurosci Lett 336:73–76PubMedCrossRefGoogle Scholar
  45. Schutter DJLG, van Honk J, Panksepp J (2004) Introducing transcranial magnetic stimulation and its property of causal inference in investigating the brain- function relationship. Synthese 141:155–173CrossRefGoogle Scholar
  46. Schutter DJLG, Enter D, Hoppenbrouwers SS (2009) High frequency repetitive transcranial magnetic stimulation to the cerebellum and implicit information processing of happy facial expressions. J Psychiatry Neurosci 34:60–65PubMedGoogle Scholar
  47. Snider RS, Maiti A (1976) Cerebellar contributions to the Papez circuit. J Neurosci Res 2:133–146PubMedCrossRefGoogle Scholar
  48. Stanfield AC, McIntosh AM, Spencer MD, Philip R, Gaur S, Lawrie SM (2008) Towards a neuroanatomy of autism: a systematic review and meta-analysis of structural magnetic resonance imaging studies. Eur Psychiatry 23:289–299PubMedCrossRefGoogle Scholar
  49. Stoodley CJ, Schmahmann JD (2009) Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Neuroimage 44:489–501PubMedCrossRefGoogle Scholar
  50. Valera EM, Faraone SV, Murray KE, Seidman LJ (2007) Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder. Biol Psychiatry 61:1361–1369PubMedCrossRefGoogle Scholar
  51. Weaver AH (2005) Reciprocal evolution of the cerebellum and neocortex in fossil humans. Proc Natl Acad Sci USA 102:3576–3580PubMedCrossRefGoogle Scholar
  52. Wise RA (2009) Roles for nigrostriatal-not just mesocorticolimbic-dopamine in reward and addiction. Trends Neurosci 32:517–524PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of Experimental Psychology, Faculty of Social SciencesUtrecht UniversityUtrechtThe Netherlands

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