Stellate Cells: Synaptic Processing and Plasticity
Stellate and basket cells in the molecular layer of the cerebellum are inhibitory interneurons which control the activity of Purkinje cells. Recent studies using genetic approaches have revealed the important function of these interneurons during behavioral tasks, motor coordination, and motor learning. Synaptic transmission onto cerebellar interneurons and interneuron inhibition onto Purkinje cells can be dynamically regulated by synaptic activity. The capacity of molecular layer interneurons to undergo activity-dependent changes in synaptic transmission and membrane excitability provides a cellular mechanism that underlies cerebellar learning and memory.
KeywordsPurkinje Cell Stellate Cell AMPA Receptor Parallel Fiber Gaba Release
This work was supported by a National Science Foundation Grant IBN-0964517 and National Institutes of Health Grant NS58867. I thank Dr. Matthew Whim for helpful comments on the manuscript.
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