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Basal Cell Carcinoma

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Braun-Falco´s Dermatology

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Abstract

Basal cell carcinomas (BCCs) represent the most common skin tumors in humans, with an increasing incidence worldwide. They occur preferentially in chronically UV-exposed areas in elderly fair-skinned individuals/Caucasians. Basal cell carcinomas originate from stem cell-like cells of the follicular epidermis. As they tend to be locally infiltrative and are known to have low metastatic potential they are referred to as semi-malignant tumors. There are various clinicopathologic subtypes, but all of them share the same genetic alterations within the aberrantly activated Hedgehog signaling pathway. With the exception of superficial BCCs, treatment consists of surgery or radiotherapy. A more recent treatment concept for patients with metastastic or unresectable BCCs consists of the use of hedgehog pathway inhibitors

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Authors and Affiliations

  1. Clinic for Dermatology, University Hospital Düsseldorf, Düsseldorf, Germany

    Julia Reifenberger

Authors
  1. Julia Reifenberger
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Correspondence to Julia Reifenberger .

Editor information

Editors and Affiliations

  1. Department of Dermatology, Venerology and Allergology, University of Munich, Munich, Germany

    Gerd Plewig

  2. Department of Dermatology, Venerology and Allergology, University of Munich, Munich, Germany

    Lars French

  3. Department of Dermatology, Venerology and Allergology, University of Munich, Munich, Germany

    Thomas Ruzicka

  4. Department of Dermatology, Venerology and Allergology, University of Frankfurt, Frankfurt, Germany

    Roland Kaufmann

  5. Department of Dermatology and Allergology, University of Marburg, Marburg, Germany

    Michael Hertl

Section Editor information

  1. Head of the Department of Dermatology, Venerology and Allergology, Frankfurt University Hospital, Frankfurt am Main, Germany

    Roland Kaufmann

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Reifenberger, J. (2022). Basal Cell Carcinoma. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-63709-8_101

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  • DOI: https://doi.org/10.1007/978-3-662-63709-8_101

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-63708-1

  • Online ISBN: 978-3-662-63709-8

  • eBook Packages: MedicineReference Module Medicine

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