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Immunologisch bedingte Infertilität

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Andrologie

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Neben anderen immun-pathologischen Prozessen im männlichen Genitaltrakt können Antispermienantikörper (ASA) zu einer immunologisch bedingten Infertilität führen. Hierbei hängt die spontane Konzeptionswahrscheinlichkeit vom Anteil der mit ASA behafteten Spermien ab. Zu den wesentlichen Pathomechanismen einer ASA-bedingten Infertilität wird die Beeinträchtigung der Fähigkeit von Spermien zur Penetration im Zervikalmukus, die Beeinträchtigung der Kapazitation und der Akrosomreaktion der Spermien sowie die Beeinträchtigung der Spermienbindung an die Zona pellucida der Eizelle gezählt. Der Nachweis der an Spermien gebundenen IgG- oder IgA-Autoantikörper erfolgt nach den Empfehlungen der WHO im Rahmen der Ejakulatanalyse im direkten MAR- oder Immunobead-Test. Da eine Kortikoid-Therapie nur einen fraglichen Therapieerfolg zeigt, können zur Überwindung der mit ASA einhergehenden männlichen Infertilität Methoden der assistierten Reproduktion angewandt werden.

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Author information

Authors and Affiliations

  1. Institut für Anatomie und Zellbiologie, Justus-Liebig-Universität Gießen, Gießen, Deutschland

    Andreas Meinhardt

  2. Sektion Konservative Andrologie, Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie, Justus-Liebig-Universität Gießen, Universitätsklinikum Gießen und Marburg GmbH, Gießen, Deutschland

    Hans-Christian Schuppe

  3. Zentrum für Reproduktionsmedizin und Andrologie, Martin Luther Universität Halle-Wittenberg, Halle (Saale), Deutschland

    Hermann M. Behre

Authors
  1. Andreas Meinhardt
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  2. Hans-Christian Schuppe
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  3. Hermann M. Behre
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Corresponding author

Correspondence to Andreas Meinhardt .

Editor information

Editors and Affiliations

  1. Centrum für Reproduktionsmedizin und And, Universität Münster, Münster, Deutschland

    Eberhard Nieschlag

  2. Zentrum für Reproduktionsmedizin und And, Universität Halle-Wittenberg Universitätsklinikum Halle (Saale), Halle, Sachsen-Anhalt, Deutschland

    Hermann M. Behre

  3. Abt. Klinische/Operative Andrologie, Universitätsklinikum Münster, Münster, Nordrhein-Westfalen, Deutschland

    Sabine Kliesch

  4. Zentrum für Reproduktionsmedizin und And, Universitätsklinikum Münster, Münster, Deutschland

    Susan Nieschlag

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© 2021 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

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Meinhardt, A., Schuppe, HC., Behre, H.M. (2021). Immunologisch bedingte Infertilität. In: Nieschlag, E., Behre, H.M., Kliesch, S., Nieschlag, S. (eds) Andrologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-61904-9_28-1

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  • DOI: https://doi.org/10.1007/978-3-662-61904-9_28-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-61904-9

  • Online ISBN: 978-3-662-61904-9

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