Abstract
During pregnancy, complex endocrinological, immunological, metabolic, and vascular changes may lead to physiological skin changes and changes in the course of pre-existent dermatoses, as well as specific dermatoses of pregnancy. This term refers to a heterogeneous group of severely itchy inflammatory dermatoses associated only with pregnancy and/or the postpartum period. After decades of confusing nomenclature, a clinically relevant classification has been established that includes pemphigoid gestationis, polymorphic eruption of pregnancy, intrahepatic cholestasis of pregnancy, and atopic eruption of pregnancy. While some of these conditions are merely unpleasant for the mother owing to pruritus, others pose a potential risk to the child. Early diagnosis and therapy is therefore essential and facilitated by a diagnostic algorithm.
In addition, skin diseases can coincidentally coincide with a pregnancy. Both diagnosis and therapy should always be critically evaluated against the background of pregnancy in order to avoid a potential impairment of the fetus.
References
Overviews
Black MM, Edwards L, Lynch P, Ambros-Rudolph CM (eds) (2008) Obstetric and gynecologic dermatology, 3rd edn. Elsevier, London
Vaughan Jones S, Ambros-Rudolph C, Nelson-Piercy C (2014) Skin disease in pregnancy. Br Med J 348:g3489
Specific Dermatoses of Pregnancy
Ambros-Rudolph CM, Müllegger RR, Vaughan Jones SA et al (2006) The specific dermatoses of pregnancy revisited and reclassified: results of a retrospective two-center study on 505 pregnant patients. J Am Acad Dermatol 54:395–404
Bay Bjorn AM, Ehrenstein V, Holmager Hundborg H et al (2014) Use of corticosteroids in early pregnancy is not associated with risk of oral clefts and other congenital malformations in offspring. Am J Ther 21(2):73–80
Chi CC, Wang SH, Mayon-White R et al (2013) Pregnancy outcomes after maternal exposure to topical corticosteroids: a UK population based cohort study. JAMA Dermatol 149:1274–1280
Geenes V, Chappell LC, Seed PT et al (2014) Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population based case-control study. Hepatology 59:1482–1491
Lammert F, Marschall HU, Glantz A et al (2000) Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. J Hepatol 33:1012–1021
Murase JE, Heller MM, Butler DC (2014) Safety of dermatologic medications in pregnancy and lactation. Part I. Pregnancy. J Am Acad Dermatol 70:401–414
Schaefer C, Spielmann H, Vetter K et al (eds) (2012) Arzneiverordnung in Schwangerschaft und Stillzeit, 8th edn. Urban & Fischer, Munich
Dermatoses Influenced by Pregnancy
Bae YS, Van Voorhees AS, Hsu S et al (2012) Review of treatment options for psoriasis in pregnant or lactating women: from the Medical Board of the National Psoriasis Foundation. J Am Acad Dermatol 67:459–477
Drsicoll MS, Martires K, Kalowitz Bieber A et al (2016) Pregnancy and melanoma. J Am Acad Dermatol 75:669–678
Kalowitz Bieber A, MartiresKJ DMS et al (2016) Nevi and pregnancy. J Am Acad Dermatol 75:661–666
Nast A, Amelunxen L, Augustin M et al (2017) S3 – Leitlinie zur Therapie der Psoriasis vulgaris – update 2017. https://www.awmf.org/uploads/tx_szleitlinien/013-001l_S3_Therapie_Psoriasis-vulgaris_2017-12.pdf
Infections During Pregnancy
Lamont RF, Sobel JD, Vaisbuch E et al (2011) Parvovirus B19 infection in human pregnancy. BJOG 118:175–186
Lautenschlager S (2006) Cutaneous manifestations of syphilis: recognition and management. Am J Clin Dermatol 7:291–304
Müllegger RR, Häring NS, Glatz M (2016) Skin infections in pregnancy. Clin Dermatol 34:368–377
Workowski KA, Bolan GA (2015) Sexually transmitted diseases treatment guidelines. MMWR Recomm Rep 64:1–137
First Describer
Alcalay J, Ingber A, Hazazaz B et al (1988) Linear IgM dermatosis of pregnancy. J Am Acad Dermatol 18:412–415
Besnier E (1904) Prurigo of pregnancy. In: Besnier E, Brocq L, Jacquet L (eds) La pratique dermatologique, vol 1. Masson, Paris, p 75
Biermann SM (1973) Autoimmune progesterone dermatitis in pregnancy. Arch Dermatol 107:896–901
Bombardieri S, Munno OB, Di Punzo C et al (1977) Erythema nodosum associated with pregnancy and oral contraceptives. Br Med J 1:1509–1510
Bourne N (1962) Toxaemic rash of pregnancy. Proc R Soc Med 55:462–464
Holmes RC, Black MM (1982) The specific dermatoses of pregnancy: a reappraisal with special emphasis on a proposed simplified clinical classification. Clin Exp Dermatol 7:65–73
Holmes RC, Black MM (1983) The specific dermatoses of pregnancy. J Am Acad Dermatol 8:405–412
Jaquet L (1904) Prurigo gestationis. In: Besnier E, Brocq L, Jacquet L (eds) La pratique dermatologique. Traité de dermatologie appliquée, vol 4 Table II. Masson, Paris, p 74
Kehrer E (1907) Die Bedeutung des Ikterus in der Schwangerschaft für Mutter und Kind. Klinische und experimentelle Untersuchungen. Arch Gyn 81:129–159
Lawley TJ, Hertz KC, Wade TR et al (1979) Pruritic urticarial papules and plaques of pregnancy. JAMA 241:1696–1699
Nurse DS (1968) Prurigo of pregnancy. Australas J Dermatol 9:258–267
Spangler AS, Reddy W, Bardawil WA et al (1962) Papular dermatitis of pregnancy. JAMA 181:577–581
Zoberman E, Farmer ER (1981) Pruritic folliculitis of pregnancy. Arch Dermatol 117:20–22
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Ambros-Rudolph, C.M. (2021). Disorders of Pregnancy. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58713-3_81-1
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