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Maligne Lymphome der Haut

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Braun-Falco's Dermatologie, Venerologie und Allergologie

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Zusammenfassung

Maligne Lymphome der Haut bilden eine heterogene Gruppe neoplastischer Erkrankungen mit einem breiten Spektrum klinischer, histologischer und phänotypischer Manifestationen, wobei die kutanen T-Zell Lymphome und hierbei insbesondere die Mycosis fungoides die häufigste Lymphomform darstellen. Häufigkeit, Prognose und somit auch Behandlung kutaner Lymphome unterscheiden sich zum Teil deutlich von denen morphologisch vergleichbarer nodaler Lymphome. Die Klassifikation kutaner Lymphome richtet sich nach der revidierten WHO-Klassifikation 2016. Die klinisch-pathologische Korrelation spielt in der Diagnose und Zuordnung eine zentrale Rolle.

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Literatur

Allgemeines

  • Burg G, Kempf W (Hrsg) (2005) Cutaneous lymphomas. Francis and Taylor, New York

    Google Scholar 

  • Cerroni L (Hrsg) (2014) Skin lymphoma: the illustrated guide, 4. Aufl. Wiley-Blackwell, Oxford

    Google Scholar 

  • Kempf W, Mitteldorf C (2015) Pathologic diagnosis of cutaneous lymphomas. Dermatol Clin 33:655–681

    Article  CAS  PubMed  Google Scholar 

  • Kempf W, Sander CA (2010) Classification of cutaneous lymphomas – an update. Histopathology 56:57–70

    Article  PubMed  Google Scholar 

  • Kim YH, Willemze R, Pimpinelli N et al (2007) TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 110:479–484

    Article  CAS  PubMed  Google Scholar 

  • Olsen E, Vonderheid E, Pimpinelli N et al (2007) Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 110:1713–1722

    Article  CAS  PubMed  Google Scholar 

  • Robson A (2010) Immunocytochemistry and the diagnosis of cutaneous lymphoma. Histopathology 56:71–90

    Article  PubMed  Google Scholar 

  • Stadler R, Assaf C, Klemke CD et al (2008) Short German guidelines: cutaneous lymphomas. J Dtsch Dermatol Ges Suppl 1:25–31

    Article  Google Scholar 

  • Swerdlow SH, Campo E, Harris NL et al (2008) WHO classification of tumours of haematopoietic and lymphoid tissues, 4. Aufl. IARC Press, Lyon

    Google Scholar 

  • Swerdlow SH, Campo E, Pileri SA et al (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplams. Blood 127:2375–2390

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Willemze R, Jaffe ES, Burg G et al (2005) WHO-EORTC classification for cutaneous lymphomas. Blood 105:3768–3785

    Article  CAS  PubMed  Google Scholar 

Mycosis fungoides

  • Flaig MJ, Cerroni L, Schuhmann K et al (2001) Follicular mycosis fungoides: a histopathologic analysis of nine cases. J Cutan Pathol 28:525–530

    Article  CAS  PubMed  Google Scholar 

  • Haghighi B, Smoller BR, LeBoit PE et al (2000) Pagetoid reticulosis (Woringer-Kolopp disease): an immunophenotypic, molecular, and clinicopathologic study. Mod Pathol 13:502–510

    Article  CAS  PubMed  Google Scholar 

  • Kazakov D, Burg G, Kempf W (2004) Clinicopathological spectrum of mycosis fungoides. J Eur Acad Dermatol Venerol 18:397–415

    Article  CAS  Google Scholar 

  • Kempf W, Ostheeren-Michaelis S, Paulli M et al (2008) Granulomatous mycosis fungoides and granulomatous slack skin: a multicenter study of the Cutaneous Lymphoma Histopathology Task Force Group of the European Organization for Research and Treatment of Cancer (EORTC). Arch Dermatol 144:1609–1617

    Article  PubMed  Google Scholar 

Andere kutane T-Zell-Lymphome

  • Assaf C, Gellrich S, Whittaker S et al (2007) CD56-positive haematological neoplasms of the skin: a multicentre study of the Cutaneous Lymphoma Project Group of the European Organisation for Research and Treatment of Cancer. J Clin Pathol 60:981–989

    Article  PubMed  Google Scholar 

  • Garcia-Herrera A, Colomo L, Camos M et al (2008) Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome. J Clin Oncol 26:3364–3371

    Article  PubMed  Google Scholar 

  • Kempf W (2014) Cutaneous CD30+ lymphoproliferative disorders. Surg Pathol Clin 7:203–228

    Article  PubMed  Google Scholar 

  • Kempf W, Pfaltz K, Vermeer MH et al (2011) European Organization for Research and Treatment of Cancer (EORTC), International Society of Cutaneous Lymphoma (ISCL) and United States Cutaneous Lymphoma Consortium (USCLC) consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Blood 118:4024–4035

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Massone C, El-Shabrawi-Caelen L, Kerl H et al (2008) The morphologic spectrum of primary cutaneous anaplastic large T-cell lymphoma: a histopathologic study on 66 biopsy specimens from 47 patients with report of rare variants. J Cutan Pathol 35:46–53

    Article  PubMed  Google Scholar 

  • Willemze R, Jansen PM, Cerroni L et al (2008) Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood 111:838–845

    Article  CAS  PubMed  Google Scholar 

Blastäre Neoplasie plasmazytoider dendritischer Zellen

  • Petrella T, Bagot M, Willemze R et al (2005) Blastic NK-cell lymphomas (agranular CD4 + CD56+ hematodermic neoplasms): a review. Am J Clin Pathol 123:662–675

    Article  PubMed  Google Scholar 

Kutane B-Zell-Lymphome

  • Cerroni L, Kerl H (2001) Primary cutaneous follicular lymphoma. Arch Dermatol 137:489–490

    CAS  PubMed  Google Scholar 

  • Ferreri AJ, Campo E, Seymour JF et al (2004) Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ,cutaneous variant‘. Br J Haematol 127:173–183

    Article  PubMed  Google Scholar 

  • Golling P, Cozzio A, Dummer R et al (2008) Primary cutaneous B-cell lymphomas – clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome. Leuk Lymphoma 49:1094–1103

    Article  PubMed  Google Scholar 

  • Hoefnagel JJ, Vermeer MH, Jansen PM et al (2005) Primary cutaneous marginal zone B-cell lymphoma: clinical and therapeutic features in 50 cases. Arch Dermatol 141:1139–1145

    Article  CAS  PubMed  Google Scholar 

  • Kodama K, Massone C, Chott A et al (2005) Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients. Blood 106:2491–2497

    Article  CAS  PubMed  Google Scholar 

  • Senff NJ, Noordijk EM, Kim YH et al (2008) European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas. Blood 112:1600–1609

    Article  CAS  PubMed  Google Scholar 

  • Servitje O, Estrach T, Pujol RM et al (2002) Primary cutaneous marginal zone B-cell lymphoma: a clinical, histopathological, immunophenotypic and molecular genetic study of 22 cases. Br J Dermatol 147:1147–1158

    Article  CAS  PubMed  Google Scholar 

Andere lymphoproliferative Erkrankungen

  • Beaty MW, Toro J, Sorbara L et al (2001) Cutaneous lymphomatoid granulomatosis: correlation of clinical and biologic features. Am J Surg Pathol 25:1111–1120

    Article  CAS  PubMed  Google Scholar 

  • Bech-Thomsen N, Thomsen K (1998) Ofuji’s papuloerythroderma: a study of 17 cases. Clin Exp Dermatol 23:79–83

    Article  CAS  PubMed  Google Scholar 

  • Sander CA, Medeiros LJ, Abruzzo LV et al (1991) Lymphoblastic lymphoma presenting in cutaneous sites. A clinicopathologic analysis of six cases. J Am Acad Dermatol 25:1023–1031

    Article  CAS  PubMed  Google Scholar 

  • Sioutus N, Kerl H, Murphy SB et al (1994) Primary cutaneous Hodgkin’s disease. Unique clinical, morphologic and immunophenotypic findings. Am J Dermatopathol 16:2–8

    Article  Google Scholar 

Erstbeschreiber

  • Ackerman AB (1978) Granulomatous slack skin. In: Ackerman AB (Hrsg) Histologic diagnosis of inflammatory skin diseases. Lea and Febiger, Philadelphia, S 483–485

    Google Scholar 

  • Alibert JLM (1806) Description des maladies de la peau observées à l’Hôpital St. Louis et exposition des meilleures méthodes suivies pour leur traitement. Barrois, Paris

    Google Scholar 

  • Bazex A, Dupré A, Christol B (1968) Chalazodermique maladie de Besnier-Boeck-Schaumann disease? Bull Soc Fr Dermatol Syphiligr 75:448–449

    CAS  PubMed  Google Scholar 

  • Berti E, Tomasini D, Vermeer MH et al (1999) Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. A distinct clinicopathological entity with an aggressive clinical behaviour. Am J Pathol 155:483–492

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Braun-Falco O, Marghescu S, Wolff HH (1973) Pagetoide Retikulose (Morbus Woringer-Kolopp). Hautarzt 24:11–21

    CAS  PubMed  Google Scholar 

  • Brocq L (1902) Les parapsoriasis. Ann Dermatol Syphilol 3:433–468

    Google Scholar 

  • Convit J, Kerdel F, Goihman M et al (1973) Progressive, atrophying, chronic granulomatous dermohypodermitis. Autoimmune disease? Arch Dermatol 107:271–274

    Article  CAS  PubMed  Google Scholar 

  • Dupont A (1965) Langsam verlaufende und klinisch gutartige Reticulopathie mit höchst maligner histologischer Struktur. Hautarzt 16:284–286

    CAS  PubMed  Google Scholar 

  • Dutcher TF, Fahey JL (1959) The histopathology oft he macroglobulinemia of Waldenström. J Natl Cancer Inst 22:887–917

    Article  CAS  PubMed  Google Scholar 

  • Hodgkin T (1832) On some morbid appearences of the absorbent glands and spleen. Med Chir Trans 17:68–114

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jacobi E (1980) Fall zur Diagnose (Poikilodermia vascularis atrophicans). Verhandlungen der Deutschen Dermatologischen Gesellschaft. 9. Kongreß Bern, S 321

    Google Scholar 

  • Liebow AA, Carrington CB, Friedman PJ (1972) Lymphomatoid granulomatosis. Hum Pathol 3:457–558

    Article  CAS  PubMed  Google Scholar 

  • Lutzner MA, Jordan HW (1968) The ultrastructure of an abnormal cell in Sézary syndrome. Blood 31:719–726

    CAS  PubMed  Google Scholar 

  • Macaulay WL (1968) Lymphomatoid papulosis. A continuing self-healing eruption, clinically benign – histologically malignant. Arch Dermatol 97:23–30

    Article  CAS  PubMed  Google Scholar 

  • Ofuji S, Furukawa F, Miyachi Y, Ohno S (1984) Papuloerythroderma. Dermatologica 169:125–130

    Article  CAS  PubMed  Google Scholar 

  • Petrella T, Dalac S, Maynadie M et al (1999) CD4+ CD56+ cutaneous neoplasms: a distinct hematological entity? Groupe Francais d’Etude des Lymphomes Cutanes (GFELC). Am J Surg Pathol 23:137–146

    Article  CAS  PubMed  Google Scholar 

  • Pfleger L, Tappeiner J (1959) Zur Kenntnis der systemisierten Endotheliomatose der cutanen Blutgefäße (Reticuloendotheliomatose?). Hautarzt 10:359–363

    CAS  PubMed  Google Scholar 

  • Russell W (1980) An address on a characteristic organism of cancer. Br Med J 2(1563):1356–1360

    Article  Google Scholar 

  • Sézary A, Bouvrain Y (1938) Érythrodermie avec présence des cellules monstrueuses dans le derme et le sang circulant. Bull Soc Fr Dermatol Syphiligr 45:254–260

    Google Scholar 

  • Stein H, Mason DY, Gerdes J et al (1985) The expression of the Hodgkin’s disease antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 66:848–858

    CAS  PubMed  Google Scholar 

  • Woringer F, Kolopp P (1939) Lésion érythématosquameuse polycyclique de l’avant-bras évoluant depuis 6 ans chez un garçonnet de 13 ans. Ann Dermatol Syphilol 10:945–958

    Google Scholar 

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Correspondence to Werner Kempf .

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Kempf, W., Stadler, R. (2017). Maligne Lymphome der Haut. In: Plewig, G., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco's Dermatologie, Venerologie und Allergologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49546-9_109-1

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  • DOI: https://doi.org/10.1007/978-3-662-49546-9_109-1

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