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Preparation of Drug Liposomes by EDTA Gradient Methods

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Liposome-Based Drug Delivery Systems

Part of the book series: Biomaterial Engineering ((BIOENG))

Abstract

The applications of ethylene diamine tetraacetic acid (EDTA) have expanded from the treatment for heavy metal poisoning to chelation therapies for atherosclerosis, heart disease, and cancer. In recent years, EDTA has been employed as a drug delivery system, in which the EDTA gradient method was used to load weakly amphiphilic base drugs into liposomes. Because EDTA can form low-solubility compounds with weakly amphiphilic base drugs such as anthracyclines, the liposomal formulations prepared by the EDTA gradient method have high drug-loading efficiency, good long-term stability, and delayed drug release. Furthermore, because of the chelation of EDTA, it can also reduce drug-related toxicity and liposome-related immune organ damage. In this chapter, the weakly amphiphilic base drugs (doxorubicin, topotecan, epirubicin, and idarubicin) were used as model drugs to introduce the EDTA gradient drug-loading method. The method presented in this part may be helpful in obtaining reliable and reproducible liposomes and experimental results.

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Authors and Affiliations

  1. College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China

    Yanzhi Song & Yihui Deng

Authors
  1. Yanzhi Song
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  2. Yihui Deng
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Corresponding author

Correspondence to Yihui Deng .

Editor information

Editors and Affiliations

  1. Beijing Key Laboratory of Molecular Pharmaceutics and New Drug System, Beijing, China

    Wan-Liang Lu

  2. Department of Pharmaceutics School of Pharmaceutical Science, Peking University, Beijing, China

    Xian-Rong Qi

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Song, Y., Deng, Y. (2021). Preparation of Drug Liposomes by EDTA Gradient Methods. In: Lu, WL., Qi, XR. (eds) Liposome-Based Drug Delivery Systems. Biomaterial Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49320-5_6

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