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Textbook of Aging Skin pp 15–30Cite as

Degenerative Changes in Aging Skin

Abstract

Increased life spans have created a need for greater understanding of the diseases of old age including the integumentary system – the skin. The skin is the largest organ of the human body and performs multiple functions, including homeostatic regulation; prevention of percutaneous loss of fluid, electrolytes, and proteins; temperature maintenance; sensory perception; and immune surveillance. Aging involves both internal aging processes and external stressors to produce consistent changes such as thinning, drying, wrinkling, and uneven pigmentation. Understanding the fundamental physiology of changes in the epidermis, dermis, and hypodermis provides a foundation for progress in understanding the dermatological needs of those whose skin is aging. Physiological changes in aged skin include changes in biochemistry, permeability, vascularization and thermoregulation, response to irritants, immune response, repair capacity and response to injury, and neurosensory perception as well as changes at the genome level. Although aging of the skin, like other systems, is inevitable, research is beginning to define ways to both delay and minimize the troublesome effects of aging on the skin.

Keywords

  • Aging skin
  • Epidermis
  • Dermis
  • Hypodermis
  • Physiology
  • Immune
  • Vascularization
  • Permeability
  • Genome
  • Structural changes

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References

  1. World Health Organization. World Health Statistics 2014. [News Release] May 15, 2014. http://www.who.int/mediacentre/news/releases/2014/world-health-statistics-2014/en/. Accessed 25 June 2014.

  2. Berman AE, Leontieva OV, Natarajan V, McCubrey JA, Demidenko ZN, Nikiforov MA. Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget. 2012;3(12):1522–32.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  3. Monteiro-Riviere NA. Introduction to histological aspects of dermatotoxicology. Microsc Res Tech. 1997;37(3):171.

    CrossRef  CAS  PubMed  Google Scholar 

  4. Klassen C, editor. Casarett and Doull’s toxicology: the basic science of poisons. New York: McGraw-Hill; 1996. p. 529–46.

    Google Scholar 

  5. Farage MA, Miller KW, Elsner P, Maibach HI. Intrinsic and extrinsic factors in skin ageing: a review. Int J Cosmet Sci. 2008;30(2):87–95.

    CrossRef  CAS  PubMed  Google Scholar 

  6. Farage MA, Miller KW, Elsner P, Maibach HI. Functional and physiological characteristics of the aging skin. Aging Clin Exp Res. 2008;20(3):195–200.

    CrossRef  PubMed  Google Scholar 

  7. Farage MA, Miller KW, Elsner P, Maibach HI. Structural characteristics of the aging skin: a review. Cutan Ocul Toxicol. 2007;26(4):343–57.

    CrossRef  PubMed  Google Scholar 

  8. Sjerobabski-Masnec I, Situm M. Skin aging. Acta Clin Croat. 2010;49(4):515–8.

    PubMed  Google Scholar 

  9. Gkogkolou P, Böhm M. Advanced glycation end products: key players in skin aging? Dermatoendocrinology. 2012;4(3):259–70.

    CrossRef  CAS  Google Scholar 

  10. Jackson SM, Williams ML, Feingold KR, Elias PM. Pathobiology of the stratum corneum. West J Med. 1993;158(3):279–85.

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Ghersetich I, Troiano M, De Giorgi V, Lotti T. Receptors in skin ageing and antiageing agents. Dermatol Clin. 2007;25(4):655–62. xi.

    CrossRef  CAS  PubMed  Google Scholar 

  12. Glogau RG. Systemic evaluation of the aging face. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. Edinburgh: Mosby; 2003. p. 2357–60.

    Google Scholar 

  13. Puizina-Ivić N. Skin aging. Acta Dermatovenerol Alp Panonica Adriat. 2008;17(2):47–54.

    Google Scholar 

  14. Helfrich YR, Yu L, Ofori A, Hamilton TA, Lambert J, King A, et al. Effect of smoking on aging of photoprotected skin: evidence gathered using a new photonumeric scale. Arch Dermatol. 2007;143(3):397–402.

    CrossRef  PubMed  Google Scholar 

  15. Koh JS, Kang H, Choi SW, Kim HO. Cigarette smoking associated with premature facial wrinkling: image analysis of facial skin replicas. Int J Dermatol. 2002;41(1):21–7.

    CrossRef  PubMed  Google Scholar 

  16. Martires KJ, Fu P, Polster AM, Cooper KD, Baron ED. Factors that affect skin aging: a cohort-based survey on twins. Arch Dermatol. 2009;145(12):1375–9.

    CrossRef  PubMed  Google Scholar 

  17. Doshi DN, Hanneman KK, Cooper KD. Smoking and skin aging in identical twins. Arch Dermatol. 2007;143(12):1543–6.

    CrossRef  PubMed  Google Scholar 

  18. Gilchrest BA. A review of skin ageing and its medical therapy. Br J Dermatol. 1996;135(6):867–75.

    CrossRef  CAS  PubMed  Google Scholar 

  19. Friedman O. Changes associated with the aging face. Facial Plast Surg Clin North Am. 2005;13(3):371–80.

    CrossRef  PubMed  Google Scholar 

  20. Duncan KO, Leffell DJ. Preoperative assessment of the elderly patient. Dermatol Clin. 1997;15(4):583–93.

    CrossRef  CAS  PubMed  Google Scholar 

  21. Hara M, Kikuchi K, Watanabe M, Denda M, Koyama J, Nomura J, et al. Senile xerosis: functional, morphological, and biochemical studies. J Geriatr Dermatol. 1993;1(3):111–20.

    Google Scholar 

  22. Farage MA, Miller KW, Berardesca E, Maibach HI. Incontinence in the aged: contact dermatitis and other cutaneous consequences. Contact Dermatitis. 2007;57(4):211–7.

    CrossRef  PubMed  Google Scholar 

  23. Farage MA, Miller KW, Berardesca E, Maibach HI. Psychosocial and societal burden of incontinence in the aged population: a review. Arch Gynecol Obstet. 2008;277(4):285–90.

    CrossRef  PubMed  Google Scholar 

  24. Kligman AM, Koblenzer C. Demographics and psychological implications for the aging population. Dermatol Clin. 1997;15(4):549–53.

    CrossRef  CAS  PubMed  Google Scholar 

  25. Farage MA, Miller KW, Berardesca E, Maibach HI. Clinical implications of aging skin: cutaneous disorders in the elderly. Am J Clin Dermatol. 2009;10(2):73–86.

    CrossRef  PubMed  Google Scholar 

  26. Harvell JD, Maibach HI. Percutaneous absorption and inflammation in aged skin: a review. J Am Acad Dermatol. 1994;31(6):1015–21.

    CrossRef  CAS  PubMed  Google Scholar 

  27. Rees JL. The genetics of sun sensitivity in humans. Am J Hum Genet. 2004;75(5):739–51.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  28. McCallion R, Li Wan Po A. Dry and photo-aged skin: manifestations and management. J Clin Pharm Ther. 1993;18(1):15–32.

    CrossRef  CAS  PubMed  Google Scholar 

  29. Elias PM. Stratum corneum architecture, metabolic activity and interactivity with subjacent cell layers. Exp Dermatol. 1996;5(4):191–201.

    CrossRef  CAS  PubMed  Google Scholar 

  30. Tagami H. Functional characteristics of the stratum corneum in photoaged skin in comparison with those found in intrinsic aging. Arch Dermatol Res. 2008;300 Suppl 1:S1–6.

    CrossRef  PubMed  Google Scholar 

  31. Roskos KV, Guy RH, Maibach HI. Percutaneous absorption in the aged. Dermatol Clin. 1986;4(3):455–65.

    CAS  PubMed  Google Scholar 

  32. Ya-Xian Z, Suetake T, Tagami H. Number of cell layers of the stratum corneum in normal skin – relationship to the anatomical location on the body, age, sex and physical parameters. Arch Dermatol Res. 1999;291(10):555–9.

    CrossRef  CAS  PubMed  Google Scholar 

  33. Mathias CG, Maibach HI. Perspectives in occupational dermatology. West J Med. 1982;137(6):486–92.

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Caspers PJ, Lucassen GW, Puppels GJ. Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin. Biophys J. 2003;85(1):572–80.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  35. Sakai S, Yasuda R, Sayo T, Ishikawa O, Inoue S. Hyaluronan exists in the normal stratum corneum. J Invest Dermatol. 2000;114(6):1184–7.

    CrossRef  CAS  PubMed  Google Scholar 

  36. Verdier-Sévrain S, Bonté F. Skin hydration: a review on its molecular mechanisms. J Cosmet Dermatol. 2007;6(2):75–82.

    CrossRef  PubMed  Google Scholar 

  37. Sougrat R, Morand M, Gondran C, Barré P, Gobin R, Bonté F, et al. Functional expression of AQP3 in human skin epidermis and reconstructed epidermis. J Invest Dermatol. 2002;118(4):678–85.

    CrossRef  CAS  PubMed  Google Scholar 

  38. Verdier-Sévrain S. Effect of estrogens on skin aging and the potential role of selective estrogen receptor modulators. Climacteric. 2007;10(4):289–97.

    CrossRef  PubMed  Google Scholar 

  39. Brincat MP, Baron YM, Galea R. Estrogens and the skin. Climacteric. 2005;8(2):110–23.

    CrossRef  CAS  PubMed  Google Scholar 

  40. Martini F. Fundamentals of anatomy and physiology. San Francisco: Benjamin-Cummings; 2004.

    Google Scholar 

  41. Grove GL. Physiologic changes in older skin. Clin Geriatr Med. 1989;5(1):115–25.

    CAS  PubMed  Google Scholar 

  42. Waller JM, Maibach HI. Age and skin structure and function, a quantitative approach (I): blood flow, pH, thickness, and ultrasound echogenicity. Skin Res Technol. 2005;11(4):221–35.

    CrossRef  PubMed  Google Scholar 

  43. Sans M, Moragas A. Mathematical morphologic analysis of the aortic medial structure. Biomechanical implications. Anal Quant Cytol Histol. 1993;15(2):93–100.

    CAS  PubMed  Google Scholar 

  44. Boss GR, Seegmiller JE. Age-related physiological changes and their clinical significance. West J Med. 1981;135(6):434–40.

    CAS  PubMed  PubMed Central  Google Scholar 

  45. Oriba HA, Bucks DA, Maibach HI. Percutaneous absorption of hydrocortisone and testosterone on the vulva and forearm: effect of the menopause and site. Br J Dermatol. 1996;134(2):229–33.

    CrossRef  CAS  PubMed  Google Scholar 

  46. Brincat M, Kabalan S, Studd JW, Moniz CF, de Trafford J, Montgomery J. A study of the decrease of skin collagen content, skin thickness, and bone mass in the postmenopausal woman. Obstet Gynecol. 1987;70(6):840–5.

    CAS  PubMed  Google Scholar 

  47. Vázquez F, Palacios S, Alemañ N, Guerrero F. Changes of the basement membrane and type IV collagen in human skin during aging. Maturitas. 1996;25(3):209–15.

    CrossRef  PubMed  Google Scholar 

  48. Suter-Widmer J, Elsner P. Age and irritation. In: Agner T, Maibah H, editors. The irritant contact dermatitis syndrome. Boca Raton: CRC Press; 1996. p. 257–65.

    Google Scholar 

  49. Fenske NA, Lober CW. Structural and functional changes of normal aging skin. J Am Acad Dermatol. 1986;15(4 Pt 1):571–85.

    CrossRef  CAS  PubMed  Google Scholar 

  50. Brégégère F, Soroka Y, Bismuth J, Friguet B, Milner Y. Cellular senescence in human keratinocytes: unchanged proteolytic capacity and increased protein load. Exp Gerontol. 2003;38(6):619–29.

    CrossRef  PubMed  Google Scholar 

  51. Sauermann K, Jaspers S, Koop U, Wenck H. Topically applied vitamin C increases the density of dermal papillae in aged human skin. BMC Dermatol. 2004;4(1):13.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  52. Phillips T, Kanj L. Clinical manifestations of skin aging. In: Squier C, Hill MW, editors. The effect of aging in oral mucosa and skin. Boca Raton: CRC Press; 1994. p. 25–40.

    Google Scholar 

  53. Wulf HC, Sandby-Møller J, Kobayasi T, Gniadecki R. Skin aging and natural photoprotection. Micron. 2004;35(3):185–91.

    CrossRef  CAS  PubMed  Google Scholar 

  54. Rogers J, Harding C, Mayo A, Banks J, Rawlings A. Stratum corneum lipids: the effect of ageing and the seasons. Arch Dermatol Res. 1996;288(12):765–70.

    CrossRef  CAS  PubMed  Google Scholar 

  55. Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM. Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J Am Acad Dermatol. 1997;37(3 Pt 1):403–8.

    CrossRef  CAS  PubMed  Google Scholar 

  56. Long CC, Marks R. Stratum corneum changes in patients with senile pruritus. J Am Acad Dermatol. 1992;27(4):560–4.

    CrossRef  CAS  PubMed  Google Scholar 

  57. Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest. 1995;95(5):2281–90.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  58. Ghadially R. Aging and the epidermal permeability barrier: implications for contact dermatitis. Am J Contact Dermat. 1998;9(3):162–9.

    CAS  PubMed  Google Scholar 

  59. Roskos KV, Guy RH. Assessment of skin barrier function using transepidermal water loss: effect of age. Pharm Res. 1989;6(11):949–53.

    CrossRef  CAS  PubMed  Google Scholar 

  60. Berardesca E, Maibach HI. Transepidermal water loss and skin surface hydration in the non invasive assessment of stratum corneum function. Derm Beruf Umwelt. 1990;38(2):50–3.

    CAS  PubMed  Google Scholar 

  61. Südel KM, Venzke K, Mielke H, Breitenbach U, Mundt C, Jaspers S, et al. Novel aspects of intrinsic and extrinsic aging of human skin: beneficial effects of soy extract. Photochem Photobiol. 2005;81(3):581–7.

    CrossRef  PubMed  Google Scholar 

  62. Fiers SA. Breaking the cycle: the etiology of incontinence dermatitis and evaluating and using skin care products. Ostomy Wound Manage. 1996;42(3):32–4. 36, 38–40, passim.

    CAS  PubMed  Google Scholar 

  63. Neerken S, Lucassen GW, Bisschop MA, Lenderink E, Nuijs TAM. Characterization of age-related effects in human skin: a comparative study that applies confocal laser scanning microscopy and optical coherence tomography. J Biomed Opt. 2004;9(2):274–81.

    CrossRef  PubMed  Google Scholar 

  64. Ashcroft GS, Horan MA, Herrick SE, Tarnuzzer RW, Schultz GS, Ferguson MW. Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans. Cell Tissue Res. 1997;290(3):581–91.

    CrossRef  CAS  PubMed  Google Scholar 

  65. Fisher GJ, Varani J, Voorhees JJ. Looking older: fibroblast collapse and therapeutic implications. Arch Dermatol. 2008;144(5):666–72.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  66. Varani J, Dame MK, Rittie L, Fligiel SEG, Kang S, Fisher GJ, et al. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 2006;168(6):1861–8.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  67. Oikarinen A. The aging of skin: chronoaging versus photoaging. Photodermatol Photoimmunol Photomed. 1990;7(1):3–4.

    CAS  PubMed  Google Scholar 

  68. Savvas M, Bishop J, Laurent G, Watson N, Studd J. Type III collagen content in the skin of postmenopausal women receiving oestradiol and testosterone implants. Br J Obstet Gynaecol. 1993;100(2):154–6.

    CrossRef  CAS  PubMed  Google Scholar 

  69. Castelo-Branco C, Figueras F, Martínez de Osaba MJ, Vanrell JA. Facial wrinkling in postmenopausal women. Effects of smoking status and hormone replacement therapy. Maturitas. 1998;29(1):75–86.

    CrossRef  CAS  PubMed  Google Scholar 

  70. Kligman AM. The treatment of photoaged human skin by topical tretinoin. Drugs. 1989;38(1):1–8.

    CrossRef  CAS  PubMed  Google Scholar 

  71. Ohta H, Makita K, Kawashima T, Kinoshita S, Takenouchi M, Nozawa S. Relationship between dermato-physiological changes and hormonal status in pre-, peri-, and postmenopausal women. Maturitas. 1998;30(1):55–62.

    CrossRef  CAS  PubMed  Google Scholar 

  72. Gilchrest BA, Stoff JS, Soter NA. Chronologic aging alters the response to ultraviolet-induced inflammation in human skin. J Invest Dermatol. 1982;79(1):11–5.

    CrossRef  CAS  PubMed  Google Scholar 

  73. Baumann L. Skin ageing and its treatment. J Pathol. 2007;211(2):241–51.

    CrossRef  CAS  PubMed  Google Scholar 

  74. Elsner P, Wilhelm D, Maibach HI. Sodium lauryl sulfate-induced irritant contact dermatitis in vulvar and forearm skin of premenopausal and postmenopausal women. J Am Acad Dermatol. 1990;23(4 Pt 1):648–52.

    CrossRef  CAS  PubMed  Google Scholar 

  75. Coenraads PJ, Bleumink E, Nater JP. Susceptibility to primary irritants: age dependence and relation to contact allergic reactions. Contact Dermatitis. 1975;1(6):377–81.

    CrossRef  CAS  PubMed  Google Scholar 

  76. Szewczuk MR, Campbell RJ. Loss of immune competence with age may be due to auto-anti-idiotypic antibody regulation. Nature. 1980;286(5769):164–6.

    CrossRef  CAS  PubMed  Google Scholar 

  77. Robinson MK. Population differences in skin structure and physiology and the susceptibility to irritant and allergic contact dermatitis: implications for skin safety testing and risk assessment. Contact Dermatitis. 1999;41(2):65–79.

    CrossRef  CAS  PubMed  Google Scholar 

  78. Baker H, Blair CP. Cell replacement in the human stratum corneum in old age. Br J Dermatol. 1968;80(6):367–72.

    CrossRef  CAS  PubMed  Google Scholar 

  79. Man MQM, Feingold KR, Thornfeldt CR, Elias PM. Optimization of physiological lipid mixtures for barrier repair. J Invest Dermatol. 1996;106(5):1096–101.

    CrossRef  Google Scholar 

  80. Muggleton-Harris AL, Reisert PS, Burghoff RL. In vitro characterization of response to stimulus (wounding) with regard to ageing in human skin fibroblasts. Mech Ageing Dev. 1982;19(1):37–43.

    CrossRef  CAS  PubMed  Google Scholar 

  81. Grove GL, Kligman AM. Age-associated changes in human epidermal cell renewal. J Gerontol. 1983;38(2):137–42.

    CrossRef  CAS  PubMed  Google Scholar 

  82. Barland CO, Zettersten E, Brown BS, Ye J, Elias PM, Ghadially R. Imiquimod-induced interleukin-1 alpha stimulation improves barrier homeostasis in aged murine epidermis. J Invest Dermatol. 2004;122(2):330–6.

    CrossRef  CAS  PubMed  Google Scholar 

  83. Grönniger E, Weber B, Heil O, Peters N, Stäb F, Wenck H, et al. Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet. 2010;6(5):e1000971.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  84. Ning MS, Andl T. Control by a hair's breadth: the role of microRNAs in the skin. Cell Mol Life Sci. 2013;70(7):1149–69.

    CrossRef  CAS  PubMed  Google Scholar 

  85. Makrantonaki E, Zouboulis CC. Dermatoendocrinology. Skin aging. Hautarzt. 2010;61(6):505–10 [in German].

    CrossRef  CAS  PubMed  Google Scholar 

  86. Makrantonaki E, Schönknecht P, Hossini AM, Kaiser E, Katsouli M, Adjaye J. Skin and brain age together: the role of hormones in the ageing process. Exp Gerontol. 2010;45(10):801–13.

    CrossRef  CAS  PubMed  Google Scholar 

  87. Danby FW. Nutrition and aging skin: sugar and glycation. Clin Dermatol. 2010;28(4):409–11.

    CrossRef  PubMed  Google Scholar 

  88. Vranesić-Bender D. The role of nutraceuticals in anti-aging medicine. Acta Clin Croat. 2010;49(4):537–44.

    PubMed  Google Scholar 

  89. Situm M, Buljan M, Cavka V, Bulat V, Krolo I, Mihić LL. Skin changes in the elderly people – how strong is the influence of the UV radiation on skin aging? Coll Antropol. 2010;34 Suppl 2:9–13.

    PubMed  Google Scholar 

  90. Kim EJ, Kim M, Jin X, Oh J, Kim JE, Chung JH. Skin aging and photoaging alter fatty acids composition, including 11,14,17-eicosatrienoic acid, in the epidermis of human skin. J Korean Med Sci. 2010;25(6):980–3.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  91. Bataille V. Melanoma. Shall we move away from the sun and focus more on embryogenesis, body weight and longevity? Med Hypotheses. 2013;81(5):846–50.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  92. Vierkötter A, Schikowski T, Ranft U, Sugiri D, Matsui M, Krämer U, et al. Airborne particle exposure and extrinsic skin aging. J Invest Dermatol. 2010;130(12):2719–26.

    CrossRef  PubMed  Google Scholar 

  93. Naftolin F. Prevention during the menopause is critical for good health: skin studies support protracted hormone therapy. Fertil Steril. 2005;84(2):293–4. discussion 295.

    CrossRef  CAS  PubMed  Google Scholar 

  94. Makrantonaki E, Bekou V, Zouboulis CC. Genetics and skin aging. Dermatoendocrinology. 2012;4(3):280–4.

    CrossRef  Google Scholar 

  95. Saint Léger D, François AM, Lévêque JL, Stoudemayer TJ, Grove GL, Kligman AM. Age-associated changes in stratum corneum lipids and their relation to dryness. Dermatologica. 1988;177(3):159–64.

    CrossRef  PubMed  Google Scholar 

  96. Holt DR, Kirk SJ, Regan MC, Hurson M, Lindblad WJ, Barbul A. Effect of age on wound healing in healthy human beings. Surgery. 1992;112(2):293–7. discussion 297–8.

    CAS  PubMed  Google Scholar 

  97. Rawlings AV. Ethnic skin types: are there differences in skin structure and function? Int J Cosmet Sci. 2006;28(2):79–93.

    CrossRef  CAS  PubMed  Google Scholar 

  98. Puizina-Ivić N, Mirić L, Carija A, Karlica D, Marasović D. Modern approach to topical treatment of aging skin. Coll Antropol. 2010;34(3):1145–53.

    PubMed  Google Scholar 

  99. Buckley C, Rustin MH. Management of irritable skin disorders in the elderly. Br J Hosp Med. 1990;44(1):24–6. 28, 30–2.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Winton Hill Business Center, The Procter & Gamble Company, Cincinnati, OH, USA

    Miranda A. Farage

  2. Department of Dermatology, University of California, 90 Medical Center Way, Surge 110, 0989, San Francisco, CA, 94143-0989, USA

    Howard I. Maibach

  3. Margoshes-Miller Consulting, LLC, Cincinnati, OH, USA

    Kenneth W. Miller

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  1. Miranda A. Farage
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  2. Kenneth W. Miller
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  3. Howard I. Maibach
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Correspondence to Miranda A. Farage .

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Editors and Affiliations

  1. Winton Hill Business Center, The Procter & Gamble Company , Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Margoshes-Miller Consulting, LLC, Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Farage, M.A., Miller, K.W., Maibach, H.I. (2017). Degenerative Changes in Aging Skin. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47398-6_4

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  • DOI: https://doi.org/10.1007/978-3-662-47398-6_4

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