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Possible Involvement of Basement Membrane Damage by Matrix Metalloproteinases, Serine Proteinases, and Heparanase in Skin Aging Process

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Textbook of Aging Skin

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Abstract

This paper briefly reviews the characteristics of photoaged skin, and the mechanisms involved in skin photoaging and repair. Sun-exposed skin shows superficial changes, such as wrinkles, sagging, telangiectasis and pigmentary changes, pathological changes such as neoplasia, and also many internal changes in the structure and function of epidermis, basement membrane, and dermis. These changes (so-called photoaging) are predominantly due to the ultraviolet (UV) component of sunlight.

Enzymes such as matrix metalloproteinases (MMPs), urinary plasminogen activator (uPA)/plasmin, and heparanase are increased in epidermis of UV-irradiated skin. These enzymes degrade epidermal basement membrane (BM) components, dermal collagen fibers, and elastic fibers. The BM, which is located at the dermal-epidermal junction, controls dermal-epidermal signaling and is essential for maintaining a healthy epidermis and dermis. Repeated BM damage occurs in sun-exposed skin compared to unexposed skin, leading to epidermal and dermal deterioration and accelerated skin aging. UV-induced skin damage is cumulative and leads to premature aging of skin. However, appropriate daily skin treatment may ameliorate photoaging by inhibiting processes causing damage and enhancing repair processes.

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Author information

Authors and Affiliations

  1. Shiseido Research Center, 2-2-1 Hayabuchi, Tsuzuki-ku, 224-8558, Yokohama, Japan

    Satoshi Amano

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  1. Satoshi Amano
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Correspondence to Satoshi Amano .

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Editors and Affiliations

  1. Winton Hill Business Center, The Procter & Gamble Company , Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Margoshes-Miller Consulting, LLC, Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Amano, S. (2017). Possible Involvement of Basement Membrane Damage by Matrix Metalloproteinases, Serine Proteinases, and Heparanase in Skin Aging Process. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47398-6_12

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  • DOI: https://doi.org/10.1007/978-3-662-47398-6_12

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47397-9

  • Online ISBN: 978-3-662-47398-6

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