Definition
Nickel carcinogenesis is the process of the formation of respiratory tumors (carcinomas) induced by inhalation of specific insoluble nickel compounds and the series of sequential steps that occur when animals or humans are exposed to specific nickel compounds that leads to tumor development. After all these steps are accomplished, the physiological mechanisms regulating control of growth in the normal cells are degraded. Hence, the normal cells are degraded and converted into tumor cells. The tumor cells then grow autonomously in an unregulated fashion and evade the host immune system, leading to development of visible tumors.
Characteristics
Nickel, the Chemical Element, and Its Ionic Species and Chemical Compounds
Nickel and iron form alloys that are found in many meteors. Nickel is also found in deposits in central regions of the Earth. Nickel is commonly found in nature. In nature, nickel is found in...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Clemens F, Landolph JR (2003) Genotoxicity of samples of nickel refinery dust. Toxicol Sci 73:114–123
Clemens F, Verma R, Ramnath J et al (2005) Amplification of the Ect2 proto-oncogene and over-expression of Ect2 mRNA and protein in nickel compound and methylcholanthrene-transformed 10T1/2 mouse fibroblast cell lines. Toxicol Appl Pharmacol 206:138–149
Cotton FA, Wilkinson G, Murillo CA et al (1999) The elements of the first transition series. 17G. Nickel: group 10, Advanced inorganic chemistry, 6th edn. Wiley Interscience, Wiley, New York, pp 835–854
Landolph JR, Verma A, Ramnath J et al (2002) Molecular biology of deregulated gene expression in transformed C3H/10T1/2 mouse embryo cell lines induced by specific insoluble carcinogenic nickel compounds. Environ Health Perspect 110(Suppl 5):845–850
Verma R, Ramnath J, Clemens F et al (2005) Molecular biology of nickel carcinogenesis: identification of differentially expressed genes in morphologically transformed C3H/10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by specific insoluble nickel compounds. Mol Cell Biochem 255:203–216
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Landolph, J.R. (2017). Nickel Carcinogenesis. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46875-3_4075
Download citation
DOI: https://doi.org/10.1007/978-3-662-46875-3_4075
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-46874-6
Online ISBN: 978-3-662-46875-3
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences