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Development of Glomerular Circulation and Function

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Book cover Pediatric Nephrology

Abstract

From the Malpighian corpuscle description and Bowman’s sketch to defining its ultrastructure and molecular function, the ways we look at the kidney glomerulus have evolved tremendously. The first systematic exploration of the body with a microscope led to the identification of “Malpighian corpuscles” as “glands” within the kidney [1]. Two centuries later, a more sophisticated microscope enabled Sir William Bowman to identify glomerular capillary tufts in animal and human kidneys and demonstrate a relationship between the capillary tuft and the renal tubule [2]. Since then, the understanding of the human glomerulus as a specialized structure uniquely adapted for renal filtration at the proximal part of the nephron has considerably advanced.

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Authors and Affiliations

  1. Department of Pediatrics, Nephrology Section, Yale School of Medicine, New Haven, CT, USA

    Alda Tufro & Ashima Gulati

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  1. Alda Tufro
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  2. Ashima Gulati
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Editors and Affiliations

  1. Department of Pediatrics, Medical College of Wisconsin, Children’s Research Institute, Children’s Hospital, Health System of Wisconsin, Milwaukee, Wisconsin, USA

    Ellis D. Avner

  2. Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    William E. Harmon

  3. Service de Néphrologie Pédiatrique, Hôpital Necker-Enfants Malades, Université Paris-Descartes, Paris, France

    Patrick Niaudet

  4. Department of Pediatrics, Wakayama Medical University, Wakayama City, Japan

    Norishige Yoshikawa

  5. Division of Nephrology, Bambino Gesù Children’s Hospital – IRCCS, Rome, Italy

    Francesco Emma

  6. Division of Nephrology and Hypertension, The Heart Institute, Cincinnati Children’s Hospital Medical Center, College of Medicine, Cincinnati, Ohio, USA

    Stuart L. Goldstein

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Tufro, A., Gulati, A. (2016). Development of Glomerular Circulation and Function. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein, S. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43596-0_2

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