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Clinical Evaluation of the Child with Suspected Renal Disease

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Book cover Pediatric Nephrology

Abstract

Renal disease in children may present with overt symptoms clearly associated with the urinary tract, such as the development of macroscopic hematuria or profound oliguria. However, in many instances, symptoms may be very nonspecific or seemingly mild. Children with chronic kidney disease present with a wide variety of symptoms including enuresis, failure to thrive, short stature, lethargy, and pallor. The onset may be silent and the progress insidious, with symptoms only developing late in the disease course. Urinary tract infection in infants and small children may, in contrast to older children, present with nonspecific manifestations including poor feeding, vomiting, irritability, abdominal pain, failure to thrive, lethargy, and restlessness. The possibility of renal disease should therefore be considered in the differential diagnosis of any child presenting to the hospital with acute or chronic symptoms.

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References

  1. Garrett WJ, Grunwald G, Robinson DE. Prenatal diagnosis of fetal polycystic kidney by ultrasound. Aust NZ J Obst Gynaecol. 1970;10:7–9.

    Article  CAS  Google Scholar 

  2. De Bruyn R, Marks SD. Postnatal investigation of fetal renal disease. Semin Fetal Neonatal Med. 2008;13:133–41.

    Article  PubMed  Google Scholar 

  3. Helin I, Persson PH. Prenatal diagnosis of urinary tract abnormalities by ultrasound. Pediatrics. 1986;78(5):879–83.

    CAS  PubMed  Google Scholar 

  4. Livera LN, Brookfield DS, Egginton JA, et al. Antenatal ultrasonography to detect fetal renal abnormalities: a prospective screening programme. BMJ. 1989;298(6685):1421–3.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Smith NC, Hau C. A six year study of the antenatal detection of fetal abnormality in six Scottish health boards. Br J Obstet Gynaecol. 1999;106:206–12.

    Article  CAS  PubMed  Google Scholar 

  6. Morris RK, Malin GL, Quinlan-Jones E, et al. Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial. Lancet. 2013;382(9903):1496–506.

    Article  PubMed Central  PubMed  Google Scholar 

  7. DeCramer S, Parant O, Beaufils S, et al. Anomalies of the TCF2 gene are the main cause of fetal bilateral hyperechogenic kidneys. J Am Soc Nephrol. 2007;18(3):923–33.

    Article  CAS  PubMed  Google Scholar 

  8. Meadow R. Munchausen syndrome by proxy. Arch Dis Child. 1982;57:92–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. McGee H. On food and cooking: the science and lore of the kitchen. New York: Simon and Schuster; 1997. p. 194.

    Google Scholar 

  10. White RH. Occurrence of S-methyl thioesters in urine of humans after they have eaten asparagus. Science. 1975;189:810–1.

    Article  CAS  PubMed  Google Scholar 

  11. Waring RH, Mitchell SC, Fenwick GR. The chemical nature of the urinary odour produced by man after asparagus ingestion. Xenobiotica. 1987;17:1363–71.

    Article  CAS  PubMed  Google Scholar 

  12. Sherry SN, Kramer I. The time of passage of the first urine by the newborn infant. J Pediatr. 1955;46:158.

    Article  CAS  PubMed  Google Scholar 

  13. Muellner S. Development of urinary control in children. JAMA. 1960;172:1256–61.

    Article  CAS  Google Scholar 

  14. Forsythe WI, Redmond A. Enuresis and spontaneous cure rate. A study of 1129 enuretics. Arch Dis Child. 1974;49(4):259–63.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Kitagawa T. Lessons learned from the Japanese nephritis screening study. Pediat Nephrol. 1988;2:256–63.

    Article  CAS  PubMed  Google Scholar 

  16. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114(2 Suppl 4th Report):555–76.

    Google Scholar 

  17. Sinha MD, Reid CJ. Evaluation of blood pressure in children. Curr Opin Nephrol Hypertens. 2007;16:577–84.

    Article  PubMed  Google Scholar 

  18. Brady TM, Redwine KM, Flynn JT. Screening blood pressure measurement in children: are we saving lives? Pediatr Nephrol. 2014;29:947–50.

    Article  PubMed  Google Scholar 

  19. Jakobbson B, Esbjorner E, Hansson S. Minimum incidence and diagnostic rate of first urinary tract infection. Pediatrics. 1999;104:222–6.

    Article  Google Scholar 

  20. Coulthard MG, Lambert H, Keir M. Occurrence of renal scars in children after their first referral for urinary tract infection. BMJ. 1997;315:918–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. Cooper WO, Hernandez-Diaz S, Arbogast PG, et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. N Engl J Med. 2006;354(23):2443–51.

    Article  CAS  PubMed  Google Scholar 

  22. Rasmussen SA, Chu SY, Kim SY, et al. Maternal obesity and risk of neural tube defects: a metaanalysis. Am J Obstet Gynecol. 2008;198(6):611–9.

    Article  PubMed  Google Scholar 

  23. Singh HP, Hurley RM, Myers TF. Neonatal hypertension: incidence and risk factors. Am J Hypertens. 1992;5:51–5.

    CAS  PubMed  Google Scholar 

  24. Thummala MR, Raju TN, Langenberg P. Isolated single umbilical artery anomaly and the risk for congenital malformations: a meta-analysis. J Pediatr Surg. 1998;33:580–5.

    Article  CAS  PubMed  Google Scholar 

  25. Darr A, Modell B. The frequency of consanguineous marriage among British Pakistanis. J Med Genet. 1988;25:186–90.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  26. Moghal NE, Milford DV, Hulton SA, Taylor CM. The prevalence and treatment of end stage renal disease in an Asian child population. Nephrol Dial Transpl. 1997;12(12):2517–20.

    Article  CAS  Google Scholar 

  27. Connolly LP, Treves ST, Connolly SA, et al. Vesicoureteric reflux in children: incidence and severity in siblings. J Urol. 1997;157(6):2287–90.

    Article  CAS  PubMed  Google Scholar 

  28. Nash D. The development of micturition control with special reference to enuresis. Ann R Coll Surg Eng. 1949;5:318–44.

    CAS  Google Scholar 

  29. Flynn JT, Alderman MH. Characteristics of children with primary hypertension seen at a referral center. Pediatr Nephrol. 2005;20(7):961–6.

    Article  PubMed  Google Scholar 

  30. Rianthovorn P, Ettenger RB. Medication non-adherence in the adolescent renal transplant recipient: a clinician’s viewpoint. Pediatr Transplant. 2005;9(3):398–407.

    Article  Google Scholar 

  31. Foster BJ, Leonard MB. Nutrition in children with kidney disease: pitfalls of popular assessment methods. Perit Dial Int. 2005;25 Suppl 3:S143–6.

    PubMed  Google Scholar 

  32. Gavrilovici C, Goldsmith DJ, Reid C. What is the role of ambulatory BP monitoring in pediatric nephrology? J Nephrol. 2004;17(5):642–52.

    PubMed  Google Scholar 

  33. Merten DF, Kirks DR. Diagnostic imaging of paediatric abdominal masses. Pediatr Clin North Am. 1985;32:1397–425.

    CAS  PubMed  Google Scholar 

  34. Ikeda M, Ito S, Hataya H, et al. Reversible posterior leukoencephalopathy in a patient with minimal change nephrotic syndrome. Am J Kidney Dis. 2001;37(4):E30.

    Article  CAS  PubMed  Google Scholar 

  35. Ishikura M, Ikeda M, Hamasaki Y, et al. Posterior reversible leukoencephalopathy syndrome in children: its high prevalence and more extensive imaging findings. Am J Kidney Dis. 2006;48(2):231–8.

    Article  PubMed  Google Scholar 

  36. Webb NJA, Coulthard MG, Trompeter RS, et al. Correlation between finger-prick and venous ciclosporin levels: association with gingival overgrowth and hypertrichosis. Pediatr Nephrol. 2007;22:2111–8.

    Article  PubMed  Google Scholar 

  37. Berlyne GM, Shaw AB. Red eyes in renal failure. Lancet. 1967;i:4–7.

    Article  Google Scholar 

  38. Deshpande SA, Watson H. Renal ultrasonography not required in babies with isolated minor ear anomalies. Arch Dis Child Fetal Neonatal Ed. 2006;91(1):F29–30.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  39. Currarino G, Coln D, Votteler G. Triad of anorectal, sacral and presacral anomalies. AJR Am J Roentgenol. 1981;137(2):395–8.

    Article  CAS  PubMed  Google Scholar 

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Shenoy, M.A., Webb, N.J.A. (2016). Clinical Evaluation of the Child with Suspected Renal Disease. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein, S. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43596-0_18

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  • DOI: https://doi.org/10.1007/978-3-662-43596-0_18

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-43595-3

  • Online ISBN: 978-3-662-43596-0

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