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The History of Psychedelics in Medicine

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Handbuch Psychoaktive Substanzen

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Abstract

Psychedelics have been used for hundreds if not thousands of years by humans. Medical research began in earnest in the West in the late nineteenth century with the discovery of mescaline. From there we saw the development of LSD in the 1940s and an increasingly important role played by psychedelics in the 1950s in the subsequent development of biological psychiatry. Psychiatry explored psychedelic therapies extensively through to the end of the 1960s when LSD was banned. Then, other drugs emerged, notably MDMA, which took abroadly similar path to LSD; being banned in the mid-1980s. However, since then, whilst the debate around recreational uses of drugs continues, there has been a resurgence of psychedelic research in the last two decades. We now see many hundreds of new publications coming from mainstream institutions around the world studying psychedelic drugs. The history of the development of psychedelics in medicine is intimately tied-in with societal, technological and cultural changes and continues to evolve.

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References

  • Angrist, B. M., Sathananthan, G., Wilk, S., & Gershon, S. (1974). Amphetamine psychosis: Behavioural and biochemical aspects. Journal of Psychiatric Research, 11, 13–23.

    Article  PubMed  Google Scholar 

  • Beringer, K. (1927). Der Meskalinrausch: Seine Geschichte Und Erscheinungsweise (pp. 42, 147). Berlin: Julius Springer.

    Google Scholar 

  • Blumenfield, M., & Glickman, L. (1967). Ten month’s experience with LSD users admitted to county psychiatric receiving hospital. New York State Journal of Medicine, 67, 1849–1853.

    PubMed  Google Scholar 

  • Bogenschutz, M. P., & Pommy, J. A. (2012). Re-examining the therapeutic potential of classical hallucinogens in the treatment of addictions. Drug Testing and Analysis Drug Testing and Analysis, 4(7–8), 543–555.

    Article  PubMed  Google Scholar 

  • Bogenschutz, M. P., Forcehimes, A. A., Pommy, J. A., Wilcox, C. E., Barbosa, P. C., & Strassman, R. J. (2015). Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study. Journal of Psychopharmacology, 29(3), 289–299.

    Article  PubMed  Google Scholar 

  • Bowdle, T. A., Radant, A. D., Cowley, D. S., Kharash, E. D., Strassman, R. J., & Roy-Byrne, P. P. (1998). Psychedelic effects of ketamine in healthy volunteers. Anesthesiology, 88, 82–88.

    Article  PubMed  Google Scholar 

  • Bowen, W. T., Soskin, R. A., & Chotlos, J. W. (1970). Lysergic acid diethylamide as a variable in the hospital treatment of alcoholism: A follow-up study. The Journal of Nervous and Mental Disease, 150, 111–118.

    Article  PubMed  Google Scholar 

  • Breakey, W., et al. (1974). Halluconogenic drugs as precipitants of schizophrenia. Psychological Medicine, 4(03), 255–261.

    Article  PubMed  Google Scholar 

  • Brown, E. (2002, September 10). Professor X. Wired, p. 9.

    Google Scholar 

  • Buckman, J., & Ling, T. (1963). Lysergic acid (Lsd 25) & ritalin the treatment of neurosis. London: Lambarde Press.

    Google Scholar 

  • Buffum, J., & Moser, C. (1986). MDMA and human sexual function. Journal of Psychoactive Drugs, 18, 355–359.

    Article  PubMed  Google Scholar 

  • Burroughs, W., & Ginsberg, A. (1963). The yage letters. San Francisco: City Lights Books.

    Google Scholar 

  • Carey, J. (March 1997). Recreational drug wars: Alcohol versus ecstasy – Referenced from the book ‘Ecstasy Reconsidered’ by Nicholas Saunders, 1997.

    Google Scholar 

  • Carhart-Harris, R. L., Williams, T. M., Sessa, B., et al. (2010). The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: A preliminary investigation of tolerability. Journal of Psychopharmacology, 25(11), 1562–1567. 2011 Nov.

    Article  PubMed  Google Scholar 

  • Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Read, L. J., Colasanti, A., et al. (2012a). Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proceedings of the National Academy of Sciences, 109(6), 2138–2143.

    Article  Google Scholar 

  • Carhart-Harris, R., et al. (2012b). Implications for psychedelic-assisted psychotherapy: Functional magnetic resonance imaging study with psilocybin. The British Journal of Psychiatry, 200, 238–244.

    Article  PubMed  Google Scholar 

  • Carhart-Harris, R. L., Muthukumaraswamy, S., Roseman, L., Kaelen, M., Droog, W., Murphy, K., Tagliazucchi, E., Schenberg, E. E., Nest, T., Orban, C., Leech, R., Williams, L. T., Williams, T. M., Bolstridge, M., Sessa, B., McGonigle, J., Sereno, M. I., Nichols, D., Hellyer, P. J., Hobden, P., Evans, J., Singh, K. D., Wise, R. G., Curran, H. V., Feilding, A., & Nutt, D. J. (2016a). Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences of the United States of America, 113(17), 4853–4858.

    Article  PubMed  PubMed Central  Google Scholar 

  • Carhart-Harris, R. L., Bolstridge, M., Rucker, J., Day, C. M. J., Erritzoe, D., Kaelen, M., Bloomfield, M., Rickard, J. A., Forbes, B., Feilding, A., Taylor, D., Pilling, S., Curran, V. H., & Nutt, D. J. (2016b). Psilocybin with psychological support for treatment-resistant depression: An open-label feasibility study. The Lancet Psychiatry. doi:10.1016/S2215-0366(16)30065-7.

    Google Scholar 

  • Chabrol, H., & Oehen, P. (2013). MDMA assisted psychotherapy found to have a large effect for chronic post-traumatic stress disorder. Journal of Psychopharmacology, 27(9), 865–866.

    Article  PubMed  Google Scholar 

  • Chambers, T. (2014). Editor’s introduction: Psychedelic resurgence – Research and therapeutic uses, past and present. Journal of Psychoactive Drugs, 46(1), 1.

    Article  PubMed  Google Scholar 

  • Chandler, A. L., & Hartman, M. A. (1960). Lysergic acid diethylamide (LSD-25) as a facilitating agent in psychotherapy. Archives of General Psychiatry, 2(3), 286–299.

    Article  Google Scholar 

  • Chwelos, N., Blewett, D. C., Smith, C., & Hoffer, A. (1959). Use of D-lysergic diethylamide in the treatment of alcoholism. Quarterly Journal of Studies of Alcohol, 20, 577–590.

    Google Scholar 

  • Cohen, S. (1960). Lysergic acid diethylaminde: Side effects and complications. Journal of Nervous and Mental Disorders, 130, 30–40.

    Article  Google Scholar 

  • Cohen, S. (1965). The beyond within. New York: Atheneum.

    Google Scholar 

  • Cohen, S., & Eisner, B. G. (1959). Use of lysergic acid diethylamide in a psychotherapeutic setting. Archives of Neurology and Psychiatry, 81(5), 615–619.

    Article  PubMed  Google Scholar 

  • Cohen, S., Fichman, L., & Eisner, B. G. (1958). Subjective reports of lysergic acid experiences in a context of psychological test performance. The American Journal of Psychiatry, 115, 30–35.

    Article  PubMed  Google Scholar 

  • Cohen, M. M., Marinello, M. J., & Back, N. (1967). Chromosomal damage in human leukocytes induced by lysergic acid diethylamide. Science, 155, 1417–1419.

    Article  PubMed  Google Scholar 

  • Cole, J. (2014). MDMA and the “ecstasy paradigm”. Journal of Psychoactive Drugs, 46(1), 44–56.

    Article  PubMed  Google Scholar 

  • Condrau, G. (1949). Clinical experience in mental patients with lysergic acid diethylamide. Acta Psychiatrica et Neurologica, 24, 9.

    Article  Google Scholar 

  • Correll, G. E., & Futter, G. E. (2006). Two case studies of patients with major depressive disorder given low-dose (subanesthetic) ketamine infusions. Pain Medicine, 7(1), 92–95.

    Article  PubMed  Google Scholar 

  • Coutinho, T. (2006). From religious ecstasy to ecstasy pills: A symbolic and performative analysis of electronic music festivals. Religião & Sociedade, 2(se), 135–157. Rio de Janeiro.

    Google Scholar 

  • Crockford, R. M. (2007). LSD in prague; a long-term follow-up study. Multidisciplinary Association for Psychedelic Studies Bulletin, XVII(1), 20–22.

    Google Scholar 

  • Dahlberg, C. C., Mechaneck, R., & Feldstein, S. (1968). LSD research: The impact of lay publicity. The American Journal of Psychiatry, 125(5), 685–689.

    Article  PubMed  Google Scholar 

  • Dishotsky, N. I., Loughman, W. D., Mogar, R. E., & Lipscomb, W. R. (1971). LSD and genetic damage. Science, 172(3982), 431–440.

    Article  PubMed  Google Scholar 

  • Ditman, K. S., & Bailey, J. J. (1967). Evaluating LSD as a psychotherapeutic agent. In Abramson, H. (Ed.), The Use of LSD in Psychotherapy and Alcoholism, (pp. 74–80). Bobbs-Merrill, New York, NY.

    Google Scholar 

  • Dobkin de Rios, M., & Janiger, O. (2003). LSD, spirituality and the creative process (pp. 1–4). Rochester: Park Street Press.

    Google Scholar 

  • Doblin, R., Greer, G., Holland, J., Jerome, L., Mithoefer, M. C., & Sessa, B. (2014). A reconsideration and response to Parrott AC (2013) Human psychobiology of MDMA or ‘Ecstasy’: An overview of 25 years of empirical research. Human Psychopharmacology, 29(2), 105–108.

    Article  PubMed  Google Scholar 

  • Eisner, B. (1989). Ecstasy: The MDMA story. Chapter one ‘introducing Adam’ (pp. 1–15). Berkley: Ronin.

    Google Scholar 

  • Eisner, B. G., & Cohen, S. (1958). Psychotherapy with lysergic acid diethylamide. The Journal of Nervous and Mental Disease, 127, 528.

    Article  PubMed  Google Scholar 

  • Emerson, A., Ponté, L., & Doblin, R. (2014). History and future of the multidisciplinary association for psychedelic studies (MAPS). Journal of Psychoactive Drugs, 46(1), 27–36.

    Article  PubMed  Google Scholar 

  • Eyerman, J. (2013). A clinical report of holotropic breathwork in 11,000 psychiatric inpatients in a community hospital setting. Multidisciplinary Association for Psychedelic Studies Bulletin Special Edition, 23(1), 24–27.

    Google Scholar 

  • Faillace, L. A., Vourlekis, A., & Szara, S. (1970). Hallucinogenic drugs in the treatment of alcoholism: A two year follow-up. Comprehensive Psychiatry, 11, 51–56.

    Article  PubMed  Google Scholar 

  • Fielding, L. (2011). To live outside the law: Caught by operation Julie. London: Serpent’s Tail.

    Google Scholar 

  • Frederking, W. (1953). Intoxicant drugs (mescaline and LSD-25) in psychotherapy. The Journal of Nervous and Mental Diseases, 121, 262.

    Article  Google Scholar 

  • Frederking, W. (1955). Intoxicant drugs (mescaline and lysergic acid diethylamide) in psychotherapy. The Journal of Nervous and Mental Disease, 121(3), 262–266.

    Article  PubMed  Google Scholar 

  • Freedman, D. X. (1961). Effects of LSD-25 on brain serotonin. The Journal of Pharmacology and Experimental Therapeutics, 134(2), 160–166.

    PubMed  Google Scholar 

  • Freeman, A. (2006). A Daniel come to judgement? Dennett and the revisioning of transpersonal theory. Journal of Consciousness Studies, 13(3), 95–109.

    Google Scholar 

  • Funkenstein, D. H. (1955). The physiology of fear and anger. Scientific American, 192(5), 74–80.

    Article  Google Scholar 

  • Gasser, P. (1995). Psycholytic therapy with MDMA and LSD in Switzerland. Newsletter of the Multidisciplinary Association for Psychedelic Studies MAPS, 5(3), 3–7.

    Google Scholar 

  • Gouzoulis-Mayfrank, E., Daumann, J., et al. (2000). Impaired cognitive performance in drug free users of recreational ecstasy (MDMA). Journal of Neurology, Neurosurgery, and Psychiatry, 68, 719–725.

    Article  PubMed  Google Scholar 

  • Graham, J. D. P., & Khalidi, A. I. (1954). The action of D-lysergic acid diethylamide (LSD 25), part 1, general pharmacology. Journal of the Faculty of Medicine (Baghdad), 18(1), 20, Summarized In Bibliography On Psychotomimetics.

    Google Scholar 

  • Greer, G. (1985). Using MDMA in psychotherapy. Advances: Journal of the Institute for the Advancement of Health, 2(2), 57–59.

    Google Scholar 

  • Greer, G., & Tolbert, R. (1986). Subjective reports of the effects of MDMA in a clinical setting. Journal of Psychoactive Drugs, 18(4), 319–327.

    Article  PubMed  Google Scholar 

  • Greer, G., & Tolbert, R. (1990). The therapeutic use of MDMA. In S. J. Peroutka (Ed.), Ecstasy: The clinical, pharmacological and neurotoxicological effects of the drug MDMA (pp. 21–36). Boston: Kluver Academic Publishers.

    Google Scholar 

  • Greer, G., Grob, C. S., & Halberstadt, A. L. (2014). PTSD symptom reports of patients evaluated for the New Mexico medical cannabis program. Journal of Psychoactive Drugs, 46(1), 73–77.

    Article  PubMed  Google Scholar 

  • Griffiths, R. R., Richards, W. A., McCann, U., & Jesse, R. (2006). Psilocybin can occasion mystical experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology, 187, 268–283.

    Article  PubMed  Google Scholar 

  • Griffiths, R. R., Johnson, M. W., Richards, W. A., McCann, U., & Richards, B. D. (2008). Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. Journal of Psychopharmacology, 22(6), 621–632.

    Article  PubMed  PubMed Central  Google Scholar 

  • Grob, C. S., Poland, R. E., Chang, L., & Ernst, T. (1996). Psychobiologic effects of 3,4- methylenedioxymethamphetamine (MDMA) in humans: Methodological considerations and preliminary observations. Behavioural Brain Research, 73, 103–107.

    Article  PubMed  Google Scholar 

  • Grob, C., Chopra, G. S., Danforth, A. L., Hagerty, M. C., McKay, C. R., Halberstadt, A. L., & Greer, G. R. (2010). Pilot study of psilocybin treatment for anxiety in advanced-stage cancer patients [with G.S.]. Archives of General Psychiatry, 68(1), 71–78.

    Article  PubMed  Google Scholar 

  • Grof, S. (1973). Theoretical and empirical basis of transpersonal psychology and psychotherapy: Observations from LSD research. Journal of Transpersonal Psychology, 5(1), 15–51.

    Google Scholar 

  • Grof, S. (1980). The effects of LSD on chromosomes, genetic mutation, fetal development and malignancy. Appendix II of LSD psychotherapy. Alameda: Hunter House Publishers.

    Google Scholar 

  • Grof, S., Halifax, J., & Kuber-Ross, E. (1977). The human encounter with death. New York: E. P. Dutton.

    Google Scholar 

  • Grof, S., et al. (2008). The past and future of the international transpersonal association. The International Journal of Transpersonal Studies, 27, 55–62.

    Google Scholar 

  • Hagenbach, D., & Werthmuller, L. (2013). Mystic chemist: The life of Albert Hofmann and his discovery of LSD (p. 61). Santa Fe: Synergetic Press.

    Google Scholar 

  • Halpern, J. H., Pope, H. G., Sherwood, A. R., Barry, S., Hudson, J. I., & Yurgelun-Todd, D. (2004). Residual neuropsychological effects of illicit 3,4- methelenedioxymethamphetamine (MDMA) in individuals with minimal exposure to other drugs. Drug Alcohol Dependency, 75, 135–147.

    Article  Google Scholar 

  • Harman, W. W., McKim, R. H., Mogar, R. E., Fadiman, J., & Stolaroff, M. J. (1966). Psychedelic agents in creative problem solving: A pilot study. Psychological Reports, 19, 211–227.

    Article  PubMed  Google Scholar 

  • Hartigan, F. (2000). Bill W.: A biography of alcoholics anonymous cofounder Bill Wilson. New York: St. Martins Press.

    Google Scholar 

  • Havelock Ellis, H. (1897). The phenomena of mescal intoxication. The Lancet, 149(3849), 1540–1542, 5.

    Article  Google Scholar 

  • Havelock Ellis, H. (1898). Mescal: A new artificial paradise. Reprint by Speculum Mundi Books, 2010.

    Google Scholar 

  • Heffter, A. (1898). Ueber Pellote. Naunyn-Schmiedebergs. Archiv für Experimentalle Pathologie und Pharmakologie, 40, 385–429.

    Article  Google Scholar 

  • Hoffer, A., Osmond, H., & Smythies, J. (1954). Schizophrenia: A new approach. Journal of Mental Science, 100, 29.

    PubMed  Google Scholar 

  • Hofmann, A. (1979). LSD: My problem child. Sarasota: Multidisciplinary Association for Psychedelic Studies. Reprint, 2005.

    Google Scholar 

  • Hofmann, A., Frey, A., Ott, H., Petrzilka, T. H., & Troxler, F. (1958). Konstitutionsaufklärung Und Synthese Von Psilocybin. Experientia, 14(11), 397.

    Article  PubMed  Google Scholar 

  • Hollister, L. E., Shelton, J., & Krieger, G. (1969). A controlled comparison of lysergic acid diethylamide (LSD) and dextroamphetmine in alcoholics. The American Journal of Psychiatry, 125, 1352–1357.

    Article  PubMed  Google Scholar 

  • Home Office. (2009). MDMA (‘ecstasy’): A review of its harms and classification under the Misuse of Drugs Act 1971. http://www.erowid.org/chemicals/mdma/mdma_info13.pdf

  • Huxley, A. (1954). The doors of perception (p. 6). London: Chatto &Windus.

    Google Scholar 

  • Huxley, L. (1968). This timeless moment. Berkley: Celestial Arts.

    Google Scholar 

  • Ingrasci, R. (1985). Testimony for MDMA hearing submitted by Richard Ingrasci, M.D., M.P.H. In the matter of MDMA scheduling. Docket no. 84–48. United States Department of Justice, Drug Enforcement Administration.

    Google Scholar 

  • Iversen, L. (2006). Speed, ecstasy, ritalin: The science of amphetamines (p. 51). Oxford: OUP.

    Google Scholar 

  • James, W. (1902). The varieties of religious experience: A study in human nature. Being the clifford lectures on natural religion delivered at Edinburgh in 1901–1902. London/Bombay: Longmans, Green, & Co.

    Google Scholar 

  • Jensen, S. E., & Ramsay, R. (1963). Treatment of chronic alcoholism with lysergic acid diethylamide. Canadian Psychiatric Association Journal, 8, 182–188.

    PubMed  Google Scholar 

  • Johnson, F. G. (1969). LSD in the treatment of alcoholism. The American Journal of Psychiatry, 126, 481–487.

    Article  PubMed  Google Scholar 

  • Johnson, M. W., Garcia-Romeu, A., Cosimano, M. P., & Griffiths, R. R. (2014). Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. Journal of Psychopharmacology, 28(11), 983–992.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jungaberle, H., Gasser, P., Weinhol, J., & Verres, R. (Eds.). (2008). Therapy with psychoactive substances. Practice and critique of psychotherapy with LSD, psilocybin and MDMA (1st ed.). Bern: Hans Huber, Hogrefe AG.

    Google Scholar 

  • Kaelen, M., Barrett, F. S., Roseman, L., Lorenz, R., Family, N., Bolstridge, M., Curran, H. V., Feilding, A., Nutt, D. J., & Carhart-Harris, R. L. (2015). LSD enhances the emotional response to music. Psychopharmacology, 232(19), 3607–3614 (2016).

    Article  PubMed  Google Scholar 

  • Kaelen, M., Roseman, L., Kahan, J., Santos-Ribeiro, A., Orban, C., Lorenz, R., Barrett, F. S., Bolstridge, M., Williams, T., Williams, L., Wall, M. B., Feilding, A., Muthukumaraswamy, S., Nutt, D. J., Carhart-Harris, R. (2016). LSDmodulates music-induced imagery via changes in parahippocampal connectivity. European Neuropsychopharmacology. pii: S0924-977X(16)30016-5. doi:10.1016/j.euroneuro.

    Google Scholar 

  • Kast, E. (1967). Attenuation of anticipation: A therapeutic use of lysergic acid diethylamide. Psychiatric Quarterly, 41(4), 646–657.

    Article  PubMed  Google Scholar 

  • Khamsi, R. (2006, August). Ketamine relieves depression within hours. New Scientist.

    Google Scholar 

  • Klüver, H. (1928). Studies on the eidetic type and on eidetic imagery. Psychology Bulletin, 25, 69–104.

    Article  Google Scholar 

  • Krebs, T. S., & Johansen, P. O. (2012). Lysergic acid diethylamide (LSD) for alcoholism: A meta-analysis of randomized controlled trials. Journal of Psychopharmacology. doi:10.1177/0269881112439253.

    PubMed  Google Scholar 

  • Krebs, T. S., & Johansen, P.-Ø. (2013). Psychedelics and mental health: A population study. PLoS ONE, 8(8), e63972. doi:10.1371/journal.pone.0063972.

    Article  PubMed  PubMed Central  Google Scholar 

  • Krupitsky, E. M., & Grinenko, A. Y. (1997). Ketamine psychedelic therapy (KPT): A review of the results of ten years of research. Journal of Psychoactive Drugs, 29(2), 165–183.

    Article  PubMed  Google Scholar 

  • Kurland, A. A., Unger, S., Shaffer, J. W., & Savage, C. (1967). Psychedelic therapy utilizing LSD in the treatment of the alcoholic patient: A preliminary report. American Journal of Psychiatry, 123(10), 1202–1209.

    Article  PubMed  Google Scholar 

  • Kurland, A. A., Savage, C., Pahnke, W. N., Grof, S., & Olsson, J. E. (1971). LSD in the treatment of alcoholism. In O. Vinar, Z. Votava, & P. B. Bradley (Eds.), Advances in neuropsychopharmacology: Proceedings of the 7th congress of the collegium international neuropsychopharma cologicum (pp. 361–372). Amsterdam: North-Holland.

    Google Scholar 

  • Laing, R. D. (1963). The divided self. London: Penguin.

    Google Scholar 

  • Laing, A. (1997). R.D. Laing: A biography. London: Harper Collins.

    Google Scholar 

  • Lebedev, A. V., Kaelen, M., Lövdén, M., Nilsson, J., Feilding, A., Nutt, D. J., & Carhart-Harris, R. L. (2016). LSD-induced entropic brain activity predicts subsequent personality change. Human Brain Mapping. doi:10.1002/hbm.23234.

    PubMed  Google Scholar 

  • Lee, M. A., Shlain, B. (1992). Acid dreams: The complete social history of LSD (pp. 44–45). Grove Atlantic Press, New York.

    Google Scholar 

  • Leuner, H. (1962). Experimental psychosis. Its psychopharmacology, phenomenology, and dynamics in relation to personality. Neurologie et Psychiatrie, 95, 1–275.

    Google Scholar 

  • Lewin, L. (1894). “Über Anhalonium Lewinii Und Andere Cacteen” – On Anhalonium Lewinii And Other Cacti. In Archives of Experimental Pathology and Pharmacology, 34(5–6), December 14, 1894 p 374–391.

    Google Scholar 

  • Liechti, M. E., & Vollenweider, F. X. (2001). Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies. Neuropsychobiology, Human Psychopharmacology: Clinical and Experimental, 16, 589–598.

    Article  Google Scholar 

  • Liechti, M. E., Gamma, A., & Vollenweider, F. X. (2001). Gender differences in the subjective effects of MDMA. Psychopharmacology, 154, 161–168.

    Article  PubMed  Google Scholar 

  • Ling, T. M., & Buckman, J. (1963). The treatment of anxiety with lysergic acid and methylphenidate. Practitioner, 191, 201–204.

    PubMed  Google Scholar 

  • Loizaga-Velder, A., & Verres, R. (2014). Therapeutic effects of ritual ayahuasca use in the treatment of substance dependence – Qualitative results. Journal of Psychoactive Drugs, 46(1), 63–72.

    Article  PubMed  Google Scholar 

  • Lotsof, H. S. (1995). Ibogaine in the treatment of chemical dependency disorders. Multidisciplinary Association for Psychedelic Studies Bulletin, 5(3), 16–27.

    Google Scholar 

  • Ludewig, S., Ludewig, K., Hasler, F., & Vollenweider, F. X. (2003). No lasting effects of moderate doses of MDMA (ecstasy) on memory performance and mood states in healthy humans. Biological Psychiatry, 53(Suppl), 205S.

    Google Scholar 

  • Ludwig, A. M., Levine, J., & Stark, L. H. (1970). LSD and alcoholism: A clinical study of treatment efficacy. Springfield: Charles C Thomas.

    Google Scholar 

  • Malleson, N. (1971). Acute adverse reactions to LSD in clinical and experimental use in the United Kingdom. The British Journal of Psychiatry, 118(543), 229–230.

    Article  PubMed  Google Scholar 

  • Martin, J. (1962). The treatment of 12 male homosexuals with LSD. Acta Psychotherapeutica, 10, 395–402.

    Article  Google Scholar 

  • Mash, D. C., Kovera, C. G., Buck, B. E., Norenberg, M. D., Shapshak, P., Hearn, W. L., & Sanchez-Ramos, J. (1998). Medication development of ibogaine as a pharmacotherapy for drug dependence. Annals of the New York Academy of Sciences, 844, 274–292.

    Article  PubMed  Google Scholar 

  • McLean, J. R., MacDonald, D. C., Byrne, U. P., & Hubbard, A. M. (1961). The use of LSD-25 in the treatment of alcoholism and other psychiatric problems. Quarterly Journal of Studies on Alcohol, 22, 3445.

    Google Scholar 

  • McLellan, A. T., Woody, G. E., & O’Brien, C. P. (1979). Development of psychiatric illness in drug abusers. Possible role of drug preference. The New England Journal of Medicine, 301, 1310–1314.

    Article  Google Scholar 

  • Mithoefer, M. C., Wagner, M. T., Mithoefer, A. T., Jerome, L., & Doblin, R. (2010). The safety and efficacy of 3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: The first randomized controlled pilot study. Journal of Psychopharmacology, 25(4), 439–452.

    Article  PubMed  Google Scholar 

  • Mithoefer, M. C., et al. (2013). Durability of improvement in PTSD symptoms and absence of harmful effects or drug dependency after MDM-assisted Psychotherapy: A prospective long-term follow-up study. Journal of Psychopharmacology, 27, 28–39.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mogar, R. E., & Aldrich, R. W. (1969). The use of psychedelic agents with autistic schizophrenic children. Behavioural Neuropsychiatry, 1(8), 44–50.

    Google Scholar 

  • Moreno, F. A., & Delgado, P. L. (1997). Hallucinogen-induced relief of obsessions and compulsions [letter]. The American Journal of Psychiatry, 154, 1037–1038.

    PubMed  Google Scholar 

  • Moreno, F. A., Wiegand, C. B., Taitano, E. K., & Delgado, P. L. (2006). Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder. The Journal of Clinical Psychiatry, 67, 1735–1740.

    Article  PubMed  Google Scholar 

  • Morgan, M. J. (2000). Ecstasy (MDMA): A review of its possible persistent psychological effects. Psychopharmacology, 152(3), 230–248.

    Article  PubMed  Google Scholar 

  • Muthukumaraswamy, S. D., Carhart-Harris, R. L., Moran, R. J., Brookes, M. J., Williams, T. M., Errtizoe, D., Sessa, B., Papadopoulos, A., Bolstridge, M., Singh, K. D., Feilding, A., Friston, K. J., & Nutt, D. J. (2013). Broadband cortical desynchronization underlies the human psychedelic state. The Journal of Neuroscience, 33(38), 15171–15183.

    Article  PubMed  Google Scholar 

  • Nichols, D. E. (2014). The Heffter research institute: Past and hopeful future. Journal of Psychoactive Drugs, 46(1), 20–26.

    Article  PubMed  Google Scholar 

  • Nutt, D. J., et al. (2007). The development of a rational scale to assess the harm of drugs of potential misuse. The Lancet, 369, 1047–1053.

    Article  Google Scholar 

  • Oehen, P., et al. (2012). A randomized, controlled pilot study of MDMA ({+/−}3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic post-traumatic stress disorder (PTSD). Journal of Psychopharmacology, 27, 40–52.

    Article  PubMed  Google Scholar 

  • Osmond, O. (1957). A review of the clinical effects of psychotomimetic agents. Annals of the New York Academy of Sciences, 66(3), 418–434.

    Article  PubMed  Google Scholar 

  • Osmond, H., & Smythies, J. (1952). Schizophrenia: A new approach. The Journal of Mental Science, 98, 309–315.

    PubMed  Google Scholar 

  • Parrott, A. C. (2014). The potential dangers of using MDMA for psychotherapy. Journal of Psychoactive Drugs, 46(1), 37–43.

    Article  PubMed  Google Scholar 

  • Passie, T. (1997). Hanscarl Leuner: Pioneer of hallucinogen research and psycholytic therapy. Multidisciplinary Association for Psychedelic Studies, 7(1), 46–49.

    Google Scholar 

  • Passie, T., Halpern, J. H., Stichtenoth, D. O., Emrich, H. M., & Hintzen, A. (2008). The pharmacology of lysergic acid diethylamide: A review. CNS Neuroscience and Therapeutics, 14(4), 295–314.

    Article  PubMed  Google Scholar 

  • Piper, A. (2013). Leo Perutz and the mystery of St Peter’s snow. Time and Mind: The Journal of Archaeology, Consciousness and Culture, 6(2), 175–198.

    Article  Google Scholar 

  • Riba, J. (1998). A pharmacological study of ayahuasca in healthy volunteers. Multidisciplinary Association for Psychedelic Studies Bulletin, 8(3), 12–15.

    Google Scholar 

  • Riba, J. (2003). Human pharmacology of ayahuasca. TESI doctoral dissertation, Universitat Autonoma de Barcelona.

    Google Scholar 

  • Riba, J., et al. (2001). Subjective effects and tolerability of the South American psychoactive beverage ayahuasca in healthy volunteers. Psychopharmacology, 154, 85–95.

    Article  PubMed  Google Scholar 

  • Riba, J., Rodriguez-Fornells, A., & Barbanoj, M. (2002). Effects of ayahuasca on sensory and sensorimotor gating in humans as measured by P50 suppression and prepulse inhibition of the startle reflex, respectively. Psychopharmacology, 165, 18–28.

    Article  PubMed  Google Scholar 

  • Ricaurte, G. A., Yuan, J., Hatzidimitriou, G., Cord, B. J., & McCann, U. D. (2002). Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA (“ecstasy”). Science, 297, 2260–2263.

    Article  PubMed  Google Scholar 

  • Ricaurte, G. A., Yuan, J., Hatzidimitriou, G., Cord, B. J., & McCann, U. D. (2003). Retraction. Science, 301, 1429.

    Article  Google Scholar 

  • Rinkel, M., Jackson, D., Hyde, R. W., & Solomon, H. C. (1952). Experimental schizophrenia-like symptoms. The American Journal of Psychiatry, 108, 572–578.

    Article  PubMed  Google Scholar 

  • Roberts, A. (2008). Albion dreaming: A popular history of LSD in Britain. London: Marshall Cavendish.

    Google Scholar 

  • Rostafinski, M. (1950). Experimental hallucination in epileptic patients. Rocznik Psychiatryczny (Poland), 38, 109; Summarized In Bibliography On Psychotomimetics, 1943–1966 (U.S. Department Of Health, Education And Welfare, Public Health Service, 1966), P. 5.

    Google Scholar 

  • Roubicek, J. (1962). Lecebny Vliv Diethylamidu Kyseliny Lysergove (LSD). [Therapeutic effect of lysergic acid diethylamide]. Activitas Nervosa Superior, 4, 240–241.

    PubMed  Google Scholar 

  • Rydzynski, Z., Cwynar, S., & Grzelak, L. (1968). Preliminary report on the experience with psychotomimetic drugs in the treatment of alcoholism. Activitas Nervosa Superior (Praha), 10(3), 273.

    Google Scholar 

  • Sandison, R., & Sessa, B. (2008). An interview with Dr Ronald Sandison – LSD pioneer in UK psychiatry. Multidisciplinary Association for Psychedelic Studies Bulletin, 3, 32–35

    Google Scholar 

  • Sandison, R. A., Spencer, A. M., & Whitelaw, J. D. (1954). The therapeutic value of LSD in mental illness. The Journal of Mental Science, 100(419), 491–507.

    PubMed  Google Scholar 

  • Sarett, M., Cheek, F., & Osmond, H. (1966). Reports of wives of alcoholics of effects of LSD-25 treatment of their husbands. Archives of General Psychiatry, 14(2), 171–178.

    Article  PubMed  Google Scholar 

  • Schifano, F., Oyefeso, A., Webb, L., Pollard, M., Corkery, J., & Ghodse, A. (2003). Review of deaths related to taking ecstasy, England and Wales, 1997–2000. BMJ [British Medical Journal], 326(7380), 80–81.

    Article  Google Scholar 

  • Schultes, R. E, Hofmann, A., & Rätsch, C. (1979). Plants of the gods (pp. 14–48). Inner Traditions. Rochester, Vermont.

    Google Scholar 

  • Selvaraj, S., et al. (2009). Brain serotonin transporter binding in former users of MDMA (‘ecstasy’). The British Journal of Psychiatry, 194, 355–359.

    Article  PubMed  Google Scholar 

  • Sessa, B. (2005). Can psychedelics have a role in psychiatry again? British Journal of Psychiatry, 186, 457–459.

    Article  PubMed  Google Scholar 

  • Sessa, B. (2006). From sacred plants to psychotherapy: The history and re-emergence of psychedelics in medicine. From the 2006 meeting of the Royal College of psychiatry’s spirituality in psychiatry special interest group. Available at http://www.rcpsych.ac.uk/pdf/Ben%20Sessa%20%20From%20Sacred%20Plants%20to%20Psychotherapy.pdf

  • Sessa, B. (2010). Self-medication of LSD and MDMA to treat mental disorders: A case series. The Journal of Alternative Medicine Research, 2(2), 245–249.

    Google Scholar 

  • Sessa, B. (2012). Could MDMA be useful in the treatment of PTSD? Progress in Neurology and Psychiatry, 15(6), 4–7, November/December 2011.

    Article  Google Scholar 

  • Sessa, B. (2015). Turn on and tune in to evidence based psychedelic research. The Lancet Psychiatry, 2(1), 10–12.

    Article  PubMed  Google Scholar 

  • Sessa, B., & Grey, A. (2015). Painting of Dr. Alexandra and Ann Shulgin by Alex Grey, with commentary from Sessa and Grey – On the cover of the British Journal of Psychiatry, 206(1), 3.

    Google Scholar 

  • Sessa, B., & Johnson, M. (2015). Is there a role for psychedelics in the treatment of drug dependency? British Journal of Psychiatry.

    Google Scholar 

  • Sessa, B., & Meckel Fischer, F. (2015). Underground LSD, MDMA and 2-CB-assisted individual and group psychotherapy in Zurich: Outcomes, implications and commentary. Journal of Independent Scientific Committee on Drugs, 1, 1–8.

    Google Scholar 

  • Sessa, B., & Nutt, D. J. (2007). MDMA, politics and medical research: Have we thrown the baby out with the bathwater? Journal of Psychopharmacology, 21, 787–791.

    Article  PubMed  Google Scholar 

  • Sessa, B. (2014) Why psychiatry needs psychedelics and psychedelics need psychiatry. Journal of Psychoactive Drugs, Jan-Mar 46(1): 57–62.

    Google Scholar 

  • Sessa, B., & Nutt, D. J. (2015). Making a medicine out of MDMA. British Journal of Psychiatry, 206(1), 4–6.

    Article  PubMed  Google Scholar 

  • Sewell, R. A., Halpern, J. H., & Pope, H. G. (2006). Response of cluster headache to psilocybin and LSD. Journal of Neurology, 66(12), 1920–1922.

    Article  Google Scholar 

  • Seymour, R. B., & Wesson, D. R. (Eds.) (1986). Proceedings from: MDMA: A multidisciplinary conference. Journal of Psychoactive Drugs, 18(6), 22–28.

    Google Scholar 

  • Shulgin, A. (1964). 3-methoxy-4,5-methylenedioxy amphetamine, a new psychotomimetic agent. Nature, 201, 1120–1121. 29.

    Article  PubMed  Google Scholar 

  • Shulgin, A. T., & Nichols, D. E. (1978). Characterization of three new psychotomimetcs. In R. C. Stillman & R. E. Willette (Eds.), The psychopharmacology of hallucinogens. New York: Pergamon Press.

    Google Scholar 

  • Shulgin, A., & Shulgin, A. (1991). PiHKAL: A chemical love story. Berkeley: Transform Press.

    Google Scholar 

  • Shulgin, A., & Shulgin, A. (1997). TiHKAL: The continuation. Berkeley: Transform Press.

    Google Scholar 

  • Smart, R. G., & Bateman, K. (1967). Unfavourable reactions to LSD: A review and analysis of the available case reports [review]. Canadian Medical Association Journal, 97, 1214–1221.

    PubMed  PubMed Central  Google Scholar 

  • Smart, R. G., Storm, T., Baker, E. F., & Solursh, L. (1966). A controlled study of lysergide in the treatment of alcoholism. 1. The effects on drinking behavior. Quarterly Journal of Studies on Alcohol, 27(3), 469–482.

    PubMed  Google Scholar 

  • Smith, C. (1958). A new adjunct to the treatment of alcoholism: The hallucinogenic drugs. Quarterly Journal of Studies on Alcohol, 19(406), 417.

    Google Scholar 

  • Smith, D. E., Raswyck, G. E., & Davidson, L. D. (2014). From Hofmann to the Haight Ashbury, and into the future: The past and potential of lysergic acid diethlyamide. Journal of Psychoactive Drugs, 46(1), 3–10.

    Article  PubMed  Google Scholar 

  • Snelders, S. (1998). The LSD therapy career of Jan Bastiaans, M.D. Newsletter of the Multidisciplinary Association for Psychedelic Studies, 8(1), 18–20.

    Google Scholar 

  • Snyder, S. H., Banerjee, S. P., Yamamura, H. I., & Greenberg, D. (1974). Drugs, neurotransmitters and schizophrenia. Science, 184(4143), 1243–1253.

    Article  PubMed  Google Scholar 

  • Späth, E. (1919). Über Die Anhalonium-Alkaloide. I. Anhalin Und Mezcalin. Monatshefte Für Chemie – Chemical Monthly, 40(2), 129–154.

    Article  Google Scholar 

  • Stockings, G. T. (1940). A clinical study of the mescaline psychosis, with special reference to the mechanism of the genesis of schizophrenic and other psychotic states. The British Journal of Psychiatry, 86, 29–47.

    Article  Google Scholar 

  • Stolaroff, M. (1994). Thanatos to eros, 35 years of psychedelic exploration. Thaneros Publishers. Berlin, Germany.

    Google Scholar 

  • Stolaroff, M. (1997). The secret chief revealed: Conversations with Leo Zeff, pioneer in the underground psychedelic therapy movement. Sarasota: Multidisciplinary Association for Psychedelic Studies (2004).

    Google Scholar 

  • Stolaroff, M. J., & Wells, C. W. (1993). Preliminary results with new psychoactive agents 2C-T-2 and 2C-T-7. In Yearbook for ethnomedicine and the study of consciousness (Vol. 2, pp. 99–117). Berlin: VBD – Verlag fur Wissenschaft und Bildung.

    Google Scholar 

  • Stoll, W. A. (1947). LSD, EinPhantastikumAusDer Mutterkorngruppe. Schweizer Archiv für Neurologie und Psychiatrie, 60, 279.

    Google Scholar 

  • Strassman, R. J. (1996). Human psychopharmacology of N,N-dimethyltryptamine. Behavioural Brain Research, 73, 121–124.

    Article  PubMed  Google Scholar 

  • Strassman, R. (2001). DMT: Spirit molecule (pp. 11–40). Rochester: Park Street Press.

    Google Scholar 

  • Ungerleider, J. T., Fisher, D. D., & Fuller, M. (1966). The dangers of LSD. Analysis of seven months’ experience in a university hospital’s psychiatric service. JAMA, 197, 389–392.

    Article  PubMed  Google Scholar 

  • Van Dusen, W., Wilson, W., Miners, W., & Hook, H. (1967). Treatment of alcoholism with lysergide. Quarterly Journal of Studies on Alcohol, 28, 295–303.

    PubMed  Google Scholar 

  • Vollenweider, F. X. (2002). Brain mechanisms of hallucinogens and entactogens. Dialogues in Clinical Neuroscience, 3(5), 265–279.

    Google Scholar 

  • Vollenweider, F. X., Liechti, M. E., Gamma, A., Greer, G., & Geyer, M. (2002). Acute psychological and neurophysiological effects of MDMA in humans. Journal of Psychoactive Drugs, 34(2), 171–184.

    Article  PubMed  Google Scholar 

  • Wasson, R.G. (1957, May 13). Seeking the magic mushroom. Life Magazine.

    Google Scholar 

  • Weir Mitchell, S. (1896). Remarks on the effects of anheloniumLewinii. The Mescal Button British Medical Journal, 2(1875), 1625–1629.

    Article  Google Scholar 

  • Winkler, P., & Csémy, L. (2014). Self-experimentations with psychedelics among mental health professionals: LSD in the former Czechoslovakia. Journal of Psychoactive Drugs, 46(1), 11–19.

    Article  PubMed  Google Scholar 

  • Zetnik, K. (Yehiel De-Nur) (1989). Bestendig voorogen. Kampen: De paddestoelwolk van Auschwitz.

    Google Scholar 

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Acknowledgements

Tremendous thanks goes to those friends and colleagues who have offered their kind words in the early development of this article, including George Greer, Rick Doblin, David Nichols, Richard Yensen, Charles Grob, Thomas Roberts, Neal Goldsmith, Andy Roberts and Jay H. Ellens.

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Sessa, B. (2016). The History of Psychedelics in Medicine. In: von Heyden, M., Jungaberle, H., Majić, T. (eds) Handbuch Psychoaktive Substanzen. Springer Reference Psychologie . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55214-4_96-1

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