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Endogene Cannabinoide und das Endocannabinoidsystem

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Handbuch Psychoaktive Substanzen

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Das Endocannabinoidsystem mit seinen endogenen Cannabinoiden, Cannabinoid- und anderen Rezeptoren sowie Proteinen, die für die Biosynthese und den Abbau von Endocannabinoiden wie Anandamid (N-Arachidonoylethanolamid) und 2-AG (2-Arachidonoylglycerol) verantwortlich sind, übt im zentralen Nervensystem und in vielen anderen Organen wichtige biologische Funktionen aus. Heute sind etwa 200 endocannabinoidähnliche Substanzen bekannt. Störungen der normalen Funktionsweise dieses Neurotransmittersystems können zu Beeinträchtigungen von Organfunktionen führen, wie beispielsweise Störungen der Hirnleistungsfähigkeit, von Fortpflanzungs-, Immun- und Magendarmfunktionen. Seine Hauptfunktion besteht in der Hemmung der Freisetzung anderer Neurotransmitter. Bei Erkrankungen kann eine spezifische Beeinflussung des Endocannabinoidsystems, beispielsweise durch eine Hemmung des Abbaus von Endocannabinoiden oder die Zufuhr pflanzlicher Cannabinoide, die an Cannabinoidrezeptoren binden oder die Konzentration von Endocannabinoiden beeinflussen, von Nutzen sein.

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Correspondence to Franjo Grotenhermen .

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Grotenhermen, F. (2016). Endogene Cannabinoide und das Endocannabinoidsystem. In: von Heyden, M., Jungaberle, H., Majić, T. (eds) Handbuch Psychoaktive Substanzen. Springer Reference Psychologie . Springer, Berlin, Heidelberg.

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  • Print ISBN: 978-3-642-55214-4

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