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Neuroendokrine Neoplasien des Magens

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Zusammenfassung

Mit ein bis zwei Erkrankungen pro 1.000.000 Personen pro Jahr handelt es sich bei den Neoplasien des Magens um eine sehr seltene Tumorentität. Bezogen auf alle gastrointestinalen neuroendokrinen Neoplasien (gNEN) sind circa 9 % primär gastrale Neoplasien. Hauptlokalisation sind Magenfundus und -korpus. Die neuroendokrinen Neoplasien des Magens sind in drei bzw. vier Subtypen unterteilt. Das therapeutische Vorgehen hängt neben dem Subtyp der gastralen neuroendokrinen Neoplasie von Funktionalität, Differenzierungsgrad, Stadium, ECOG-Performance-Status und nicht zuletzt der Komorbidität des Patienten ab. Prognostisch bestehen erhebliche Unterschiede zwischen den gNEN-Subtypen.

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Literatur

  • Bordi C (1999) Gastric carcinoids. Ital J Gastroenterol Hepatol 31(Suppl 2):S 94–S 97

    Google Scholar 

  • du Bois A, Lück HJ, Meier W et al (2003) A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J Natl Cancer Inst 95:1320–1329

    Article  PubMed  Google Scholar 

  • Klöppel G (2003) Vom-Karzinoid-zum-neuroendokrinen-Tumor-Klassifizierung-im-Magen-Darm-Trakt-und-Pankreas. Dtsch Arztebl 100(28–29):A-1932/B-1605/C-1513

    Google Scholar 

  • Modlin IM, Lye KD, Kidd M (2003) A 5-decade analysis of 13,715 carcinoid tumors. Cancer 97:934–959

    Article  PubMed  Google Scholar 

  • Moertel CG, Kvols LK, O’Connell MJ et al (1991) Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin: evidence of major therapeutic activity in the anaplastic variants of these neoplasms. Cancer 68:227–232

    Article  CAS  PubMed  Google Scholar 

  • Pavel M, Baudin E, Couvelard A, Krenning E et al (2012) ENETS consensus guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary. Neuroendocrinology 95:157–176

    Article  CAS  PubMed  Google Scholar 

  • RAMSETE RAD001 in advanced and metastatic silent neuro-endocrine tumors in Europe (RAMSETE/CDE16)

    Google Scholar 

  • Rappel S, Altendorf-Hofmann A, Stolte M (1995) Prognosis of gastric carcinoid tumours. Digestion 56(6):455–462

    Article  CAS  PubMed  Google Scholar 

  • Rindi G, Azzoni C, La Rosa S et al (1999) ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: prognostic evaluation by pathological analysis. Gastroenterology 116:532–542

    Article  CAS  PubMed  Google Scholar 

  • Rinke A, Muller HH, Schade-Brittinger C et al (2009) Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol 27:4656–4663

    Article  CAS  PubMed  Google Scholar 

  • Strosberg J, Coppola D, Klimstra DS et al (2010) The NANETS consensus guidelines for the diagnosis and management of poorly differentiated (high-grade) extrapulmonary neuroendocrine carcinomas. Pancreas 39:799–800

    Article  PubMed Central  PubMed  Google Scholar 

  • Welin S, Sorbye H, Sebjornsen S et al (2011) Clinical effect of temozolomide-based chemotherapy in poorly differentiated endocrine carcinoma after progression on first-line chemotherapy. Cancer 11:4617–4622

    Article  Google Scholar 

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Correspondence to Kim Luley .

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Luley, K. (2015). Neuroendokrine Neoplasien des Magens. In: Lehnert, H., et al. DGIM Innere Medizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54676-1_509-1

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  • DOI: https://doi.org/10.1007/978-3-642-54676-1_509-1

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  • Online ISBN: 978-3-642-54676-1

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Chapter history

  1. Latest

    Neuroendokrine Neoplasien des Magens
    Published:
    27 August 2023

    DOI: https://doi.org/10.1007/978-3-642-54676-1_509-2

  2. Original

    Neuroendokrine Neoplasien des Magens
    Published:
    13 October 2015

    DOI: https://doi.org/10.1007/978-3-642-54676-1_509-1