Skip to main content

Tumoren des Dünndarms

  • Living reference work entry
  • Latest version View entry history
  • First Online:
Book cover DGIM Innere Medizin

Part of the book series: Springer Reference Medizin ((SRM))

  • 216 Accesses

Zusammenfassung

Dünndarmtumoren zählen zu den seltenen Neoplasien, denn sie repräsentieren weniger als 2 % aller gastrointestinalen Tumoren. Dabei treten die Dünndarmtumoren überwiegend im proximalen Dünndarm auf und zeigen häufig ein malignes Wachstum. Die beiden häufigsten Tumorentitäten im Dünndarm sind das Adenokarzinom und die neuroendokrinen Tumoren (NET). Seltenere maligne Tumoren sind die Lymphome und die gastrointestinalen Stromatumoren (GIST). Häufig werden Dünndarmtumoren erst im fortgeschrittenen Stadium diagnostiziert, denn sie verlaufen lange asymptomatisch oder die Symptome sind unspezifisch. Mittels diagnostischer Methoden wie z. B. der Enteroskopie, Kapselendoskopie, aber auch moderner radiologischer bildgebender Verfahren können Dünndarmtumoren allerdings heute oft frühzeitiger diagnostiziert werden. Die Therapie der Dünndarmtumoren variiert erheblich je nach Tumorentität und ist in vielen Fällen interdisziplinär anzugehen. Die Fortschritte im Bereich der Diagnostik und das verbesserte pathogenetische Verständnis der Dünndarmtumoren lassen hoffen, dass zukünftig auch häufiger kurative Therapieansätze gefunden werden können.

Die Originalversion dieses Kapitels wurde revidiert: Der Korrespondenzautor wurde geändert.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Literatur

  • Agaimy A, Wunsch PH (2009) Lymph node metastasis in gastrointestinal stromal tumours (GIST) occurs preferentially in young patients <= 40 years: an overview based on our case material and the literature. Langenbecks Arch Surg 394:375–381

    Article  PubMed  Google Scholar 

  • Agrawal S, McCarron EC, Gibbs JF, Nava HR, Wilding GE, Rajput A (2007) Surgical management and outcome in primary adenocarcinoma of the small bowel. Ann Surg Oncol 14:2263–2269

    Article  PubMed  Google Scholar 

  • Al-Saleem T, Al-Mondhiry H (2005) Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms. Blood 105:2274–2280

    Article  CAS  PubMed  Google Scholar 

  • Anzidei M, Napoli A, Zini C, Kirchin MA, Catalano C, Passariello R (2011) Malignant tumours of the small intestine: a review of histopathology, multidetector CT and MRI aspects. Br J Radiol 84(1004):677–690

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arber N, Moshkowitz M (2011) Small bowel polyposis syndromes. Curr Gastroenterol Rep 13:435–441

    Article  PubMed  Google Scholar 

  • Beaton C, Davies M, Beynon J (2012) The management of primary small bowel and colon lymphoma – a review. Int J Colorectal Dis 27(5):555–563

    Article  PubMed  Google Scholar 

  • Bilimoria KY, Bentrem DJ, Wayne JD, Ko CY, Bennett CL, Talamonti MS (2009) Small bowel cancer in the United States: changes in epidemiology, treatment, and survival over the last 20 years. Ann Surg 249:63–71

    Article  PubMed  Google Scholar 

  • Bodei L, Mueller-Brand J, Baum RP, Pavel ME, Hörsch D, O'Dorisio MS, O'Dorisio TM, Howe JR, Cremonesi M, Kwekkeboom DJ, Zaknun JJ (2013) The joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours. Eur J Nucl Med Mol Imaging 40:800–816

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bosman FT, Carneiro F, Hruban RH, Theise ND (2010) WHO classification of tumours, Bd. 3 IARC WHO classification of tumours, no 3

    Google Scholar 

  • Candelaria M, de la Garza J, Duenas-Gonzalez A (2005) A clinical and biological overview of gastrointestinal stromal tumors. Med Oncol 22:1–10

    Article  CAS  PubMed  Google Scholar 

  • Caplin ME, Pavel M, Ćwikła JB, Phan AT, Raderer M, Sedláčková E, Cadiot G, Wolin EM, Capdevila J, Wall L, Rindi G, Langley A, Martinez S, Blumberg J, Ruszniewski P, CLARINET Investigators (2014) Lanreotide in metastatic enteropancreatic neuroendocrine tumors. N Engl J Med 371:224–233

    Article  PubMed  Google Scholar 

  • Chetty R (2008) An overview of practical issues in the diagnosis of gastroenteropancreatic neuroendocrine pathology. Arch Pathol Lab Med 132:1285–1289

    PubMed  Google Scholar 

  • Coit DG (2001) Cancer of the small intestine. In: DeVita VT Jr (Hrsg) Cancer principles and practice of oncology. 6. Aufl. Cancer Lippincott, Phiadelphia, S 1204–1207

    Google Scholar 

  • Cronin CG, Scott J, Kambadakone A, Catalano OA, Sahani D, Blake MA, McDermott S (2012) Utility of positron emission tomography/CT in the evaluation of small bowel pathology. Br J Radiol 85:1211–1221

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cross AJ, Leitzmann MF, Subar AF, Thompson FE, Hollenbeck AR, Schatzkin A (2008) A prospective study of meat and fat intake in relation to small intestinal cancer. Cancer Res 68:9274–9279

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • d'Amore F, Brincker H, Gronbaek K, Thorling K, Pedersen M, Jensen MK, Andersen E, Pedersen NT, Mortensen LS (1994) Non-Hodgkin’s lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathologic presentation features, and prognosis. Danish Lymphoma Study Group. J Clin Oncol 12:1673–1684

    PubMed  Google Scholar 

  • Daum S, Zeitz M (2007) Dünndarmtumoren. In: Riemann JF, Fischbach W, Galle PR, Mössner J (Hrsg) Gastroenterologie-Das Referenzwerk für Klinik und Praxis. Georg Thieme Verlag, Ludwigshafen/Aschaffenburg/Mainz/Leipzig, S 698–716

    Google Scholar 

  • Daum S, Weiss D, Hummel M, Ullrich R, Heise W, Stein H, Riecken EO, Foss HD (2001) Frequency of clonal intraepithelial T lymphocyte proliferations in enteropathy-type intestinal T cell lymphoma, coeliac disease, and refractory sprue. Gut 49:804–812

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Daum S, Ullrich R, Heise W, Dederke B, Foss HD, Stein H, Thiel E, Zeitz M, Riecken EO (2003) Intestinal non-Hodgkin's lymphoma: a multicenter prospective clinical study from the German Study Group on Intestinal non-Hodgkin's Lymphoma. J Clin Oncol 21:2740–2746

    Article  PubMed  Google Scholar 

  • Delabie J, Holte H, Vose JM, Ullrich F, Jaffe ES, Savage KJ, Connors JM, Rimsza L, Harris NL, Muller-Hermelink K, Rudiger T, Coiffier B, Gascoyne RD, Berger F, Tobinai K, Au WY, Liang R, Montserrat E, Hochberg EP, Pileri S, Federico M, Nathwani B, Armitage JO, Weisenburger DD (2012) Enteropathy-associated T-cell lymphoma: clinical and histological findings from the international peripheral T-cell lymphoma project. Blood 118:148–155

    Article  Google Scholar 

  • Delle Fave G, Kwekkeboom DJ, Van Cutsem E, Rindi G, Kos-Kudla B, Knigge U, Sasano H, Tomassetti P, Salazar R, Ruszniewski P (2012) ENETS Consensus Guidelines for the management of patients with gastroduodenal neoplasms. Neuroendocrinology 95:74–87

    Article  CAS  PubMed  Google Scholar 

  • Demetri GD, Reichardt P, Kang YK, Blay JY, Rutkowski P, Gelderblom H, Hohenberger P, Leahy M, von Mehren M, Joensuu H, Badalamenti G, Blackstein M, Le Cesne A, Schöffski P, Maki RG, Bauer S, Nguyen BB, Xu J, Nishida T, Chung J, Kappeler C, Kuss I, Laurent D, Casali PG, GRID Study Investigators (2013) Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 381(9863):295–302

    Article  CAS  PubMed  Google Scholar 

  • Edge S, Byrd DR, Compton CC, Fritz AG, Greene F L, Trotti A (2010) AJCC cancer staging manual, Aufl. 7

    Google Scholar 

  • Ferreri AJ, Zinzani PL, Govi S, Pileri SA (2011) Enteropathy-associated T-cell lymphoma. Crit Rev Oncol Hematol 79(1):84–90

    Article  PubMed  Google Scholar 

  • Fischbach W (2013) Gastric mucosal-associated lymphoid tissue lymphoma. Gastroenterol Clin North Am 42(2):371–380

    Article  PubMed  Google Scholar 

  • Fischbach W, Daum S (2003) Gastrointestinal lymphoma (Review). Dtsch Med Wochenschr 128(37):1899–1901

    Article  CAS  PubMed  Google Scholar 

  • Gassler N, Knuchel R (2012) Tumors of Vater’s ampulla. Pathologe 33:17–23

    Article  CAS  PubMed  Google Scholar 

  • Gustafsson BI, Kidd M, Modlin IM (2008) Neuroendocrine tumors of the diffuse neuroendocrine system. Curr Opin Oncol 20:1–12

    Article  PubMed  Google Scholar 

  • Hartel M, Wente MN, Sido B, Friess H, Buchler MW (2005) Carcinoid of the ampulla of Vater. J Gastroenterol Hepatol 20:676–681

    Article  PubMed  Google Scholar 

  • Hawkes EA, Wotherspoon A, Cunningham D (2012) Diagnosis and management of rare gastrointestinal lymphomas. Leuk Lymphoma 53(12):2341–2350

    Article  PubMed  Google Scholar 

  • He Q, Bai Y, Zhi FC, Gong W, Gu HX, Xu ZM, Cai JQ, Pan DS, Jiang B (2013) Double-balloon enteroscopy for mesenchymal tumors of small bowel: nine years’ experience. World J Gastroenterol 19:1820–1826

    Article  PubMed  PubMed Central  Google Scholar 

  • Heise W (2010) GI-lymphomas in immunosuppressed patients (organ transplantation;HIV). Best Pract Res Clin Gastroenterol 24(1):57–69

    Article  PubMed  Google Scholar 

  • Howe JR, Karnell LH, Menck HR, Scott-Conner C (1999) The American College of Surgeons Commission on Cancer and the American Cancer Society. Adenocarcinoma of the small bowel: review of the National Cancer Data Base, 1985–1995. Cancer 86:2693–2706

    Article  CAS  PubMed  Google Scholar 

  • Joensuu H, Vehtari A, Riihimaki J, Nishida T, Steigen SE, Brabec P, Plank L, Nilsson B, Cirilli C, Braconi C, Bordoni A, Magnusson MK, Linke Z, Sufliarsky J, Federico M, Jonasson JG, Dei Tos AP, Rutkowski P (2012) Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. Lancet Oncol 13:265–274

    Article  PubMed  Google Scholar 

  • Joensuu H, Hohenberger P, Corless CL (2013) Gastrointestinal stromal tumour. Lancet 382:973–983

    Article  CAS  PubMed  Google Scholar 

  • Karatzas G, Kouraklis G, Karayiannakis A, Patapis P, Givalos N, Kaperonis E (2000) Ampullary carcinoid and jejunal stromal tumour associated with von Recklinghausen’s disease presenting as gastrointestinal bleeding and jaundice. Eur J Surg Oncol 26:428–429

    Article  CAS  PubMed  Google Scholar 

  • Kim HK, Lo SK (2013) Endoscopic approach to the patient with benign or malignant ampullary lesions. Gastrointest Endosc Clin N Am 23:347–383

    Article  PubMed  Google Scholar 

  • Koch P, del Valle F, Berdel WE, Willich NA, Reers B, Hiddemann W, Grothaus-Pinke B, Reinartz G, Brockmann J, Temmesfeld A, Schmitz R, Rube C, Probst A, Jaenke G, Bodenstein H, Junker A, Pott C, Schultze J, Heinecke A, Parwaresch R, Tiemann M (2001) Primary gastrointestinal non-Hodgkin’s lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study GIT NHL 01/92. J Clin Oncol 19:3861–3873

    CAS  PubMed  Google Scholar 

  • König J, Kaiser A, Opfermann P, Manner H, Pohl J, Ell C, May AD (2014) Acute complications after endoscopic resection of duodenal adenomas. Z Gastroenterol 52(2):187–192

    Article  PubMed  Google Scholar 

  • Kulichová D, Schauber J, Ruzicka T (2014) Hautmanifestationen bei gastrointestinalen Erkrankungen. Skin changes as signs of gastrointestinal disorders. Dtsch med Wochenschr 139(28/29):1482–1488

    Article  PubMed  Google Scholar 

  • Kulke MH, Mayer RJ (1999) Carcinoid tumors. N Engl J Med 340(11):858–868

    Article  CAS  PubMed  Google Scholar 

  • Lai EC, Lau SH, Lau WY (2012) Current management of gastrointestinal stromal tumors – a comprehensive review. Int J Surg 10:334–340

    Article  PubMed  Google Scholar 

  • Lamba G, Gupta R, Lee B, Ambrale S, Liu D (2013) Current management and prognostic features for gastrointestinal stromal tumor (GIST). Exp Hematol Oncol 1:14

    Article  Google Scholar 

  • Le Cesne A, Blay JY, Reichardt P, Joensuu H (2013) Optimizing tyrosine kinase inhibitor therapy in gastrointestinal stromal tumors: exploring the benefits of continuous kinase suppression. Oncologist 18:1192–1199

    Article  PubMed  PubMed Central  Google Scholar 

  • Lecuit M, Abachin E, Martin A, Poyart C, Pochart P, Suarez F, Bengoufa D, Feuillard J, Lavergne A, Gordon JI, Berche P, Guillevin L, Lortholary O (2004) Immunoproliferative small intestinal disease associated with Campylobacter jejuni. N Engl J Med 350:239–248

    Article  CAS  PubMed  Google Scholar 

  • Lembcke B, Weber K, Hohenberger W (2011) Dünndarmtumoren. In: Domschke W, Berger M, Hohenberger W, Meinerth T, Rascher W (Hrsg) Therapiehandbuch. Urban & Fischer, München, S 407–418

    Google Scholar 

  • Lewis BS, Eisen GM, Friedman S (2005) A pooled analysis to evaluate results of capsule endoscopy trials. Endoscopy 37:960–965

    Article  CAS  PubMed  Google Scholar 

  • Lucci-Cordisco E, Risio M, Venesio T, Genuardi M (2013) The growing complexity of the intestinal polyposis syndromes. Am J Med Genet A 161A:2777–2787

    Article  PubMed  Google Scholar 

  • Ludwig E, Kurtz RC (2010) Tumors of the small intestine. In: Feldman M, Friedman LS, Brandt LJ (Hrsg) Sleisenger and Fordtran’s gastrointestinal and liver disease. Saunders Elsevier, Philadelphia, S 2145–2155

    Chapter  Google Scholar 

  • Malamut G, Chandesris O, Verkarre V, Meresse B, Callens C, Macintyre E, Bouhnik Y, Gornet JM, Allez M, Jian R, Berger A, Châtellier G, Brousse N, Hermine O, Cerf-Bensussan N, Cellier C (2013) Enteropathy associated T cell lymphoma in celiac disease: a large retrospective study. Dig Liver Dis 45(5):377–384

    Article  CAS  PubMed  Google Scholar 

  • Marth T, Schmitt-Graff A, Zimmer T, Riecken EO, Wiedenmann B (1996) Gastric hamartoma and thyroid gland carcinoma with follicular and neuroendocrine differentiation in Cowden syndrome. Z Gastroenterol 34:30–35

    CAS  PubMed  Google Scholar 

  • Miettinen M, Lasota J (2006) Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 130:1466–1478

    CAS  PubMed  Google Scholar 

  • Miettinen M, El-Rifai W, Sobin LHL, Lasota J (2002) Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum Pathol 33:478–483

    Article  PubMed  Google Scholar 

  • Modlin IM, Shapiro MD, Kidd M (2004) Carcinoid tumors and fibrosis: an association with no explanation. Am J Gastroenterol 99:2466–2478

    Article  PubMed  Google Scholar 

  • Modlin IM, Kidd M, Latich I, Zikusoka MN, Shapiro MD (2005) Current status of gastrointestinal carcinoids. Gastroenterology 128:1717–1751

    Article  PubMed  Google Scholar 

  • Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Delle Fave G, Kaltsas GA, Krenning EP, Moss SF, Nilsson O, Rindi G, Salazar R, Ruszniewski P, Sundin A (2008) Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 9:61–72

    Article  CAS  PubMed  Google Scholar 

  • Nakamura S, Matsumoto T (2013) Gastrointestinal lymphoma: recent advances in diagnosis and treatment. Digestion 87:182–188

    Article  PubMed  Google Scholar 

  • Napoleon B, Gincul R, Ponchon T, Berthiller J, Escourrou J, Canard JM, Boyer J, Barthet M, Ponsot P, Laugier R, Helbert T, Coumaros D, Scoazec JY, Mion F, Saurin JC (2014) Endoscopic papillectomy for early ampullary tumors: long-term results from a large multicenter prospective study. Endoscopy 46:127–134

    Article  PubMed  Google Scholar 

  • Nicholl MB, Ahuja V, Conway WC, Vu VD, Sim MS, Singh G (2010) Small bowel adenocarcinoma: understaged and undertreated? Ann Surg Oncol 17:2728–2732

    Article  PubMed  Google Scholar 

  • Oberg K (2006) Molecular imaging in diagnosis of neuroendocrine tumours. Lancet Oncol 7:790–792

    Article  PubMed  Google Scholar 

  • Overman MJ (2009) Recent advances in the management of adenocarcinoma of the small intestine. Gastrointest Cancer Res 3:90–96

    PubMed  PubMed Central  Google Scholar 

  • Overman MJ (2013) Rare but real: management of small bowel adenocarcinoma. Am Soc Clin Oncol Educ Book 33:189–193

    Article  Google Scholar 

  • Overman MJ, Hu CY, Kopetz S, Abbruzzese JL, Wolff RA, Chang GJ (2012) A population-based comparison of adenocarcinoma of the large and small intestine: insights into a rare disease. Ann Surg Oncol 19:1439–1445

    Article  PubMed  PubMed Central  Google Scholar 

  • Pavel ME, Hainsworth JD, Baudin E, Peeters M, Hörsch D, Winkler RE, Klimovsky J, Lebwohl D, Jehl V, Wolin EM, Oberg K, Van Cutsem E, Yao JC, RADIANT-2 Study Group (2011) Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study. Lancet 378(9808):2005–2012

    Article  CAS  PubMed  Google Scholar 

  • Rindi G, Kloppel G, Couvelard A, Komminoth P, Korner M, Lopes JM, McNicol AM, Nilsson O, Perren A, Scarpa A, Scoazec JY, Wiedenmann B (2007) TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch 451:757–762

    Article  CAS  PubMed  Google Scholar 

  • Rinke A, Müller HH, Schade-Brittinger C, Klose KJ, Barth P, Wied M, Mayer C, Aminossadati B, Pape UF, Bläker M, Harder J, Arnold C, Gress T, Arnold R, PROMID Study Group (2009) Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol 27:4656–4663

    Article  CAS  PubMed  Google Scholar 

  • Robert Koch-Institut und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (2013) Krebs in Deutschland 2009/2010. 9. Ausgabe, Berlin

    Google Scholar 

  • Scherübl H, Jensen RT, Cadiot G, Stolzel U, Kloppel G (2011) Management of early gastrointestinal neuroendocrine neoplasms. World J Gastrointest Endosc 3:133–139

    Article  PubMed  PubMed Central  Google Scholar 

  • Schmoll HJ, Höffken K, Possinger K (2005) Kompendium Internistische Onkologie. Teil 3: Standards in Diagnostik und Therapie. Springer, Heidelberg, S 404–408

    Google Scholar 

  • Schuchardt C, Kulkarni HR, Prasad V, Zachert C, Müller D, Baum RP (2013) The Bad Berka dose protocol: comparative results of dosimetry in peptide receptor radionuclide therapy using (177)Lu-DOTATATE, (177)Lu-DOTANOC, and (177)Lu-DOTATOC. Recent Results Cancer Res 194:519–536

    Article  CAS  PubMed  Google Scholar 

  • Serrano C, George S (2014) Recent advances in the treatment of gastrointestinal stromal tumors. Ther Adv Med Oncol 6:115–127

    Article  PubMed  PubMed Central  Google Scholar 

  • Singeltary B, Ghose A, Sussman J, Choe K, Olowokure O (2014) Durable response with a combination of imatinib and sorafenib in KIT exon 17 mutant gastrointestinal stromal tumor. J Gastrointest Oncol 5:E27–E29

    PubMed  PubMed Central  Google Scholar 

  • Strosberg J (2012) Neuroendocrine tumours of the small intestine. Best Pract Res Clin Gastroenterol 26:755–773

    Article  CAS  PubMed  Google Scholar 

  • Terris B, Meddeb M, Marchio A, Danglot G, Flejou JF, Belghiti J, Ruszniewski P, Bernheim A (1998) Comparative genomic hybridization analysis of sporadic neuroendocrine tumors of the digestive system. Genes Chromosomes Cancer 22:50–56

    Article  CAS  PubMed  Google Scholar 

  • Tonnies H, Toliat MR, Ramel C, Pape UF, Neitzel H, Berger W, Wiedenmann B (2001) Analysis of sporadic neuroendocrine tumours of the enteropancreatic system by comparative genomic hybridisation. Gut 48:536–541

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Various authors: ENETS consensus guidelines for the diagnosis and treatment of neuroendocrine tumors (2009–12) http://www.enets.org/guidelines_tnm_classifications.html. Zugegriffen am 03.08.2015

  • Wardelmann E, Hohenberger P, Reichardt P, Merkelbach-Bruse S, Schildhaus HU, Büttner R (2010) Gastrointestinal stromal tumors of the stomach. Updates and differences compared to other locations. Pathologe 31:195–198

    Article  CAS  PubMed  Google Scholar 

  • Yamamoto S, Nakase H, Yamashita K, Matsuura M, Takada M, Kawanami C, Chiba T (2010) Gastrointestinal follicular lymphoma: review of the literature. J Gastroenterol 45(4):270–288

    Article  Google Scholar 

  • Yang F, Jin C, Du Z, Subedi S, Jiang Y, Li J, Di Y, Zhou Z, Tang F, Fu D (2013) Duodenal gastrointestinal stromal tumor: clinicopathological characteristics, surgical outcomes, long term survival and predictors for adverse outcomes. Am J Surg 206:360–367

    Article  PubMed  Google Scholar 

  • Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, Evans DB (2008) One hundred years after „carcinoid“: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 26:3063–3072

    Article  PubMed  Google Scholar 

  • Yin L, Chen CQ, Peng CH, Chen GM, Zhou HJ, Han BS, Li HW (2007) Primary small-bowel non-Hodgkin’s lymphoma: a study of clinical features, pathology, management and prognosis. Int Med Res 35(3):406–15. PMID: 17593870

    Google Scholar 

  • Zentrum für Krebsregisterdaten im Robert Koch-Institut, Prävalenz, www.krebsdaten.de. Zugegriffen am 03.08.2015. (Zeitpunkt der Abfrage 2014)

  • Zettl A, deLeeuw R, Haralambieva E, Mueller-Hermelink HK (2007) Enteropathy-type T-cell lymphoma. Am J Clin Pathol 127(5):701–706

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Thomas Marth .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Zeuß, D., Marth, T. (2016). Tumoren des Dünndarms. In: Lehnert, H., et al. DGIM Innere Medizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54676-1_336-2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-54676-1_336-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-54676-1

  • eBook Packages: Springer Referenz Medizin

Publish with us

Policies and ethics

Chapter history

  1. Latest

    Tumoren des Dünndarms
    Published:
    23 February 2016

    DOI: https://doi.org/10.1007/978-3-642-54676-1_336-2

  2. Original

    Tumoren des Dünndarms
    Published:
    23 May 2015

    DOI: https://doi.org/10.1007/978-3-642-54676-1_336-1