Encyclopedia of Immunotoxicology

2016 Edition
| Editors: Hans-Werner Vohr

Proinflammatory Cytokine

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-54596-2_201221

A cytokine that supports an inflammatory response by stimulating leukocytes to an enhanced activity towards microbial agents or other antigenic compounds. Usually associated with induction of other inflammatory mediators, e.g., prostaglandins or leukotrienes. Principal proinflammatory cytokines are TNF-α and IL-1 or IL-6. These cytokines activate multiple inflammatory response pathways, including the lymphocyte response in delayed type IV hypersensitivity.

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