Encyclopedia of Immunotoxicology

2016 Edition
| Editors: Hans-Werner Vohr

Primate Immune System (Nonhuman) and Environmental Contaminants

  • Helen TryphonasEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-642-54596-2_1216


 Ape;  Simian


The subject of chemically induced alterations on structural and functional components of the immune system is rapidly becoming a major part of research in toxicology. Such research is required to support the evaluation of potentially adverse health effects of chemicals. While a few examples of direct exposure of humans to potentially harmful chemicals exist, the majority of data supporting evaluation is currently generated in experimental animal models such as rodents and canine species. However, it is known that considerable differences exist in the structure and function of the immune systems of human and experimental animal models. Therefore, it is recommended that the extrapolation of data from experimental animals to humans be made with caution. To maximize the degree of relevance of experimental data to the human situation, scientists in established nonhuman primate centers continue to develop and validate methodologies in several monkey species....

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Toxicology Research DivisionFood Directorate, Health Products and Food BranchOttawaCanada