Encyclopedia of Immunotoxicology

2016 Edition
| Editors: Hans-Werner Vohr

Porcine Immune System

  • Ricki M. Helm
Reference work entry
DOI: https://doi.org/10.1007/978-3-642-54596-2_1204

Synonyms

 Minipig;  Pig;  Swine

Short Description

The physiological and immunological similarities of swine and humans have become important features in large-animal models for biomedical research as evidenced in both veterinary and human literature citations (Tumbleson and Schook 1996). Swine are suitable for studies of developmental immunology, xenotransplantation, wound healing, immunization schemes, allergy, and human asthma. The physiological relevance of the swine as an intended target species directly affects the laboratory “proof of concept” that can be translated to successful clinical treatments in lieu of human trials. The different strains of pigs and miniature pigs available, crucial natural disease models that occur in outbred populations, combined with the rapidly growing swine immune reagent repertoire, will provide cost-effective studies that will reveal the importance of the swine as valid animal model systems that will more closely extrapolate to the human situation...

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References

  1. Boersma WJ, Zwarat RJ, Sinkora J, Rehakova Z, Haverson K, Bianchi AT (2001) Summary of workshop findings for porcine B-cell markers. Vet Immunol Immunopathol 80:63–78PubMedCrossRefGoogle Scholar
  2. Butler JE, Howard C (2002) Summary of the comparative immunoglobulin workshop (CIgW) on immunoglobulins and Fc receptors. Vet Immunol Immunopathol 87:481–484PubMedCrossRefGoogle Scholar
  3. Haverson K et al (2001) Overview of the third international workshop on swine leukocyte differentiation antigens. Vet Immunol Immunopathol 80:5–32PubMedCrossRefGoogle Scholar
  4. Helm RM, Furuta GT, Stanley JS et al (2002) A neonatal swine model for peanut allergy. J Allergy Clin Immunol 109:136–142PubMedCrossRefGoogle Scholar
  5. Tumbleson ME, Schook LB (eds) (1996) Advances in swine in biomedical research, vols 1 and 2. Plenum Press, New YorkGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Arkansas Children’s Hospital Research Institute, Arkansas Children’s Nutrition CenterUniversity of Arkansas for Medical SciencesLittle RockUSA