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Chronic Kidney Disease

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Pediatric Surgery

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Abstract

Congenital anomalies of kidney and the urinary tract constitute the commonest cause of chronic kidney disease (CKD) in children. The incidence and prevalence of CKD in children is underreported because of lack of symptoms in initial stages of the disease, though increased use of antenatal ultrasonography is helping diagnose more patients before they become symptomatic. Growth failure in pre-pubertal children with CKD is a common complication. Nutritional management is, therefore, critically important and this often involves gavage feeding in younger children. Those with persistent growth failure also need recombinant growth hormone administration. Long-term renal replacement therapy for end-stage kidney disease (ESKD) is possible even in babies and infants. Kidney transplantation significantly improves the life expectancy of ESKD patents. A multidisciplinary team that includes psychosocial support is essential for the management of children with advanced CKD.

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References

  • Akchurin OM. Chronic Kidney Disease and Dietary Measures to Improve Outcomes. Pediatr Clin North Am. 2019;66(1):247–67.

    Article  PubMed  PubMed Central  Google Scholar 

  • Astor BC, Muntner P, Levin A, Eustace JA, Coresh J. Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988-1994). Arch Intern Med. 2002;24(162):1401–8.

    Article  Google Scholar 

  • Azukaitis K, Jankauskiene A, Schaefer F, Shroff R. Pathophysiology and consequences of arterial stiffness in children with chronic kidney disease. Pediatr Nephrol. 2021;36(7):1683–95.

    Article  PubMed  Google Scholar 

  • Besarab A, Bolton WK, Browne JK, Egrie JC, Nissenson AR, Okamoto DM, Schwab SJ, Goodkin DA. The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. N Engl J Med. 1998;339(9):584–90. https://doi.org/10.1056/NEJM199808273390903. PMID: 9718377.

  • Chapter 1: Definition and classification of CKD. Kidney Int Suppl. 2013;3:19–62.

    Article  Google Scholar 

  • Chapter 1: Diagnosis and evaluation of anemia in CKD. Kidney Int Suppl. 2012;2:288–91.

    Article  Google Scholar 

  • Chapter 1: Introduction and definition of CKD–MBD and the development of the guideline statements. Kidney Int. 2009;76:S3–8.

    Google Scholar 

  • Chapter 2: Use of iron to treat anemia in CKD. Kidney Int Suppl. 2012;2:292–8.

    Article  Google Scholar 

  • Chapter 6: Blood pressure management in children with CKD ND. Kidney Int Suppl. 2012;2:372–6.

    Article  Google Scholar 

  • Chertow GM, Burke SK, Raggi P. Treat to Goal Working Group: Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int. 2002;62:245–52.

    Article  CAS  PubMed  Google Scholar 

  • Cop Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, Reddan D; CHOIR Investigators. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med. 2006;355(20):2085–98. https://doi.org/10.1056/NEJMoa065485. PMID: 17108343.

  • Dharnidharka VR, Fiorina P, Harmon WE. Kidney transplantation in children. N Engl J Med. 2014;7(371):549–58.

    Article  CAS  Google Scholar 

  • Donnelly S. Why is erythropoietin made in the kidney? The kidney functions as a critmeter. Am J Kidney Dis Off J Natl Kidney Found. 2001;38:415–25.

    Article  CAS  Google Scholar 

  • Drube J, Wan M, Bonthuis M, WĂĽhl E, Bacchetta J, Santos F, Grenda R, Edefonti A, Harambat J, Shroff R, Tönshoff B, Haffner D. European Society for Paediatric Nephrology Chronic Kidney Disease Mineral and Bone Disorders, Dialysis, and Transplantation Working Groups. Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease. Nat Rev Nephrol. 2019;15(9):577–89.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • ESCAPE Trial Group, WĂĽhl E, Trivelli A, Picca S, Litwin M, Peco-Antic A, et al. Strict blood-pressure control and progression of renal failure in children. N Engl J Med. 2009;22(361):1639–50.

    Google Scholar 

  • Fadrowski JJ, Pierce CB, Cole SR, Moxey-Mims M, Warady BA, Furth SL. Hemoglobin decline in children with chronic kidney disease: baseline results from the chronic kidney disease in children prospective cohort study. Clin J Am Soc Nephrol CJASN. 2008;3:457–62.

    Article  CAS  PubMed  Google Scholar 

  • Fine RN. Etiology and treatment of growth retardation in children with chronic kidney disease and end-stage renal disease: a historical perspective. Pediatr Nephrol Berl Ger. 2010;25:725–32.

    Article  Google Scholar 

  • Fukumoto S. Phosphate metabolism and vitamin D. BoneKEy Rep. 2014;3:497.

    PubMed  PubMed Central  Google Scholar 

  • Graf L, Candelaria S, Doyle M, Kaskel F. Nutrition assessment and hormonal influences on body composition in children with chronic kidney disease. Adv Chronic Kidney Dis. 2007;14:215–23.

    Article  PubMed  Google Scholar 

  • Harambat J, van Stralen KJ, Kim JJ, Tizard EJ. Epidemiology of chronic kidney disease in children. Pediatr Nephrol Berl Ger. 2012;27:363–73.

    Article  Google Scholar 

  • Holliday MA, Segar WE. The maintenance need for water in parenteral fluid therapy. Pediatrics. 1957;19:823–32.

    Article  CAS  PubMed  Google Scholar 

  • KDOQI, National Kidney Foundation. KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease. Am J Kidney Dis Off J Natl Kidney Found. 2006;47:S11–145.

    Article  Google Scholar 

  • KDOQI (2009) https://www.ajkd.org/article/S0272-6386(08)01621-1/fulltext

  • Kraut JA, Madias NE. Consequences and therapy of the metabolic acidosis of chronic kidney disease. Pediatr Nephrol Berl Ger. 2011;26:19–28.

    Article  Google Scholar 

  • Larson-Nath C, Goday P. Malnutrition in Children With Chronic Disease. Nutr Clin Pract. 2019;34(3):349–58.

    Article  PubMed  Google Scholar 

  • Levey AS, Stevens LA, Coresh J. Conceptual model of CKD: applications and implications. Am J Kidney Dis Off J Natl Kidney Found. 2009;53:S4–16.

    Article  Google Scholar 

  • Mahesh S, Kaskel F. Growth hormone axis in chronic kidney disease. Pediatr Nephrol Berl Ger. 2008;23:41–8.

    Article  Google Scholar 

  • Masson I, Maillard N, Tack I, Thibaudin L, Dubourg L, Delanaye P, et al. GFR estimation using standardized cystatin C in kidney transplant recipients. Am J Kidney Dis Off J Natl Kidney Found. 2013;61:279–84.

    Article  CAS  Google Scholar 

  • Menon S, Valentini RP, Kapur G, Layfield S, Mattoo TK. Effectiveness of a multidisciplinary clinic in managing children with chronic kidney disease. Clin J Am Soc Nephrol CJASN. 2009;4:1170–5.

    Article  PubMed  Google Scholar 

  • Mitch WE. Mechanisms accelerating muscle atrophy in catabolic diseases. Trans Am Clin Climatol Assoc. 2000;111:258–69. discussion 269–270

    CAS  PubMed  PubMed Central  Google Scholar 

  • Mitsnefes MM. Cardiovascular morbidity and mortality in children with chronic kidney disease in North America: lessons from the USRDS and NAPRTCS databases. Perit Dial Int J Int Soc Perit Dial. 2005;25(Suppl 3):S120–2.

    Article  Google Scholar 

  • MĂĽller D, Goldstein SL. Hemodialysis in children with end-stage renal disease. Nat Rev Nephrol. 2011;7:650–8.

    Article  PubMed  Google Scholar 

  • National Kidney Foundation. K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis Off J Natl Kidney Found. 2003;42:S1–201.

    Google Scholar 

  • Ng DK, Matheson MB, Warady BA, Mendley SR, Furth SL, Muñoz A. Incidence of Initial Renal Replacement Therapy Over the Course of Kidney Disease in Children. Am J Epidemiol. 2019;188(12):2156–64.

    Article  PubMed  PubMed Central  Google Scholar 

  • Peralta CA, Norris KC, Li S, Chang TI, Tamura MK, Jolly SE, et al. Blood pressure components and end-stage renal disease in persons with chronic kidney disease: the Kidney Early Evaluation Program (KEEP). Arch Intern Med. 2012;9(172):41–7.

    Article  Google Scholar 

  • Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, Feyzi JM, Ivanovich P, Kewalramani R, Levey AS, Lewis EF, McGill JB, McMurray JJ, Parfrey P, Parving HH, Remuzzi G, Singh AK, Solomon SD, Toto R; TREAT Investigators. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med. 2009;361(21):2019–32. https://doi.org/10.1056/NEJMoa0907845. Epub 2009 Oct 30. PMID: 19880844.

  • Rees L, Shaw V. Nutrition in children with CRF and on dialysis. Pediatr Nephrol Berl Ger. 2007;22:1689–702.

    Article  Google Scholar 

  • Ruggenenti P, Perna A, Gherardi G, Gaspari F, Benini R, Remuzzi G. Renal function and requirement for dialysis in chronic nephropathy patients on long-term ramipril: REIN follow-up trial. Gruppo Italiano di Studi Epidemiologici in Nefrologia (GISEN). Ramipril Efficacy in Nephropathy. Lancet. 1998;17(352):1252–6.

    Article  Google Scholar 

  • Schaefer F, Warady BA. Peritoneal dialysis in children with end-stage renal disease. Nat Rev Nephrol. 2011;7:659–68.

    Article  PubMed  Google Scholar 

  • Schwartz GJ, Work DF. Measurement and estimation of GFR in children and adolescents. Clin J Am Soc Nephrol CJASN. 2009;4:1832–43.

    Article  PubMed  Google Scholar 

  • Schwartz GJ, Brion LP, Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am. 1987;34:571–90.

    Article  CAS  PubMed  Google Scholar 

  • Schwartz GJ, Furth S, Cole SR, Warady B, Muñoz A. Glomerular filtration rate via plasma iohexol disappearance: pilot study for chronic kidney disease in children. Kidney Int. 2006;69:2070–7.

    Article  CAS  PubMed  Google Scholar 

  • Vidi SR. Role of hypertension in progression of chronic kidney disease in children. Curr Opin Pediatr. 2018;30(2):247–51.

    Article  PubMed  Google Scholar 

  • Warady BA, Chadha V. Chronic kidney disease in children: the global perspective. Pediatr Nephrol Berl Ger. 2007;22:1999–2009.

    Article  Google Scholar 

  • Wong CJ, Moxey-Mims M, Jerry-Fluker J, Warady BA, Furth SL. CKiD (CKD in children) prospective cohort study: a review of current findings. Am J Kidney Dis Off J Natl Kidney Found. 2012;60:1002–11.

    Article  Google Scholar 

  • Ziegler EE, Fomon SJ. Potential renal solute load of infant formulas. J Nutr. 1989;119:1785–8.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Pediatrics (Nephrology) and Urology, Wayne State University School of Medicine, Detroit, MI, USA

    Tej K. Mattoo

  2. Pediatric Nephrology and Hypertension Children’s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA

    Sweety A. Srivastava & Melissa Gregory

Authors
  1. Tej K. Mattoo
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  2. Sweety A. Srivastava
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  3. Melissa Gregory
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Correspondence to Tej K. Mattoo .

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Editors and Affiliations

  1. Beacon Hospital, University College Dublin, Dublin, Ireland

    Prem Puri

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Mattoo, T.K., Srivastava, S.A., Gregory, M. (2022). Chronic Kidney Disease. In: Puri, P. (eds) Pediatric Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38482-0_170-1

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  • DOI: https://doi.org/10.1007/978-3-642-38482-0_170-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38482-0

  • Online ISBN: 978-3-642-38482-0

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