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Optical neural control; Photostimulation
A neuromodulatory set of tools and techniques in neuroscience that involve the introduction of light-sensitive proteins, called opsins, into living cells and into the intact brain of freely moving animals to permit real-time control (both electrical and biochemical) of genetically defined populations of cells and neural circuits with both high spatial and temporal precision.
Principles and Role in Psychopharmacology
Neuropsychiatric Illness as a Disease of Altered Brain Circuitry
A paradigm shift is occurring in how scientists and clinicians fundamentally think of neuropsychiatric diseases. Although psychopathology has long been thought to represent underlying neural chemical imbalances, it is becoming increasingly recognized that such an approach may not fully capture the complexity of neuropsychiatric illness. Indeed, pharmaceutical research and development based on this chemical imbalance approach has produced drugs that...
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- Sidor MM, Mcclung CA (2014) Timing matters: using optogenetics to chronically manipulate neural circuitry and rhythms. Front Behav Neurosci 8:41. doi:10.3389/fnbeh.2014.00041Google Scholar