Encyclopedia of Biophysics

Living Edition
| Editors: Gordon Roberts, Anthony Watts, European Biophysical Societies

Nucleobase-Ascorbate-Transporter (NAT) Family

  • Anezia Kourkoulou
  • Claudio Scazzocchio
  • Stathis Frillingos
  • Emmanuel Mikros
  • Bernadette Byrne
  • George Diallinas
Living reference work entry

Later version available View entry history

DOI: https://doi.org/10.1007/978-3-642-35943-9_10090-1



The NAT/NCS2 family, designated A.2.40 (Saier et al. 2006, 2009), consists of thousands of proteins identified in all major domains of life, from archaea and bacteria to plants and animals (Pantazopoulou and Diallinas 2007; Diallinas and Gournas 2008; Gournas et al. 2008; Frillingos 2012). Prominent evolutionary gene-losses of NATs have been identified in several yeasts, including Saccharomyces cerevisiae, and in major pathogenic protozoa (e.g., Leishmania, Trypanosoma, or Plasmodium). The proteins of the NAT family are 414–650 amino acid residues in length and possess 14 transmembrane mostly α-helical segments (TMHs) characterized by a 7-helix inverted repeat (see later). Eukaryotic NAT members have extended N- and C-terminal cytoplasmic regions that include cis-acting amino acid sequence motifs controlling their traffic to the plasma membrane, as well as their turnover by constitutive or physiologically or...
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Copyright information

© European Biophysical Societies’ Association (EBSA) 2018

Authors and Affiliations

  • Anezia Kourkoulou
    • 1
  • Claudio Scazzocchio
    • 2
  • Stathis Frillingos
    • 3
  • Emmanuel Mikros
    • 4
  • Bernadette Byrne
    • 5
  • George Diallinas
    • 1
  1. 1.Department of BiologyNational and Kapodistrian University of Athens, PanepistimioupolisAthensGreece
  2. 2.Department of MicrobiologyLondonUK
  3. 3.Laboratory of Biological Chemistry, Department of MedicineUniversity of Ioannina School of Health SciencesIoanninaGreece
  4. 4.Department of PharmacologyNational and Kapodistrian University of Athens, PanepistimioupolisAthensGreece
  5. 5.Department of Life SciencesImperial College LondonLondonUK

Section editors and affiliations

  • Peter J. F. Henderson
    • 1
  1. 1.Astbury Centre for Structural Molecular Biology, Institute of Membrane and Systems BiologyUniversity of LeedsLeedsUK