Encyclopedia of Biophysics

Living Edition
| Editors: Gordon Roberts, Anthony Watts, European Biophysical Societies

Na+/Melibiose Membrane Transport Protein, MelB

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-35943-9_10082-1

Synonyms

Introduction

Melibiose permease (MelB) is encoded by the melB gene in the melAB operon, which is present in many Gram-negative bacteria. MelB belongs to the glycoside–pentoside–hexuronide:cation symporter (GPH) family (TC 2.A.2) of the major facilitator superfamily (MFS). MelB catalyzes the transport of di- or trisaccharides containing a d-galactopyranosyl ring or galactose, and the native substrate is melibiose, a disaccharide formed by an α-1,6 linkage between galactose and glucose ( d-Gal-α(1 → 6)- d-Glc) (Fig. 1). It can be also formed by invertase-mediated hydrolysis of raffinose, which produces one melibiose and one fructose.
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References

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Copyright information

© European Biophysical Societies’ Association (EBSA) 2018

Authors and Affiliations

  1. 1.Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein ResearchTexas Tech University Health Sciences CenterLubbockUSA

Section editors and affiliations

  • Peter J. F. Henderson
    • 1
  1. 1.Astbury Centre for Structural Molecular Biology, Institute of Membrane and Systems BiologyUniversity of LeedsLeedsUK