Table 2 In vitro toxicity test for local eye and skin toxicity accepted by the OECD for regulatory purposes (classification and labelling)

1. Skin absorption: OECD TG 428 “Skin absorption: in vitro method”

2. Skin corrosion: OECD TG 430 “In vitro skin corrosion: transcutaneous electrical resistance test method (TER)”

3. Skin corrosion: OECD TG 431 “In vitro skin corrosion: reconstructed human epidermis (RhE) test method”

4. Phototoxicity: OECD TG 432 “In vitro 3T3 NRU phototoxicity test”

5. Severe eye irritation and corrosion: OECD TG 437 “Bovine corneal opacity and permeability (BCOP) test for ocular corrosives and severe irritants”

6. Severe eye irritation and corrosion: OECD TG 438 “Isolated chicken eye (ICE) test method for ocular corrosives and severe irritants”

7. Skin irritation: OECD TG 439 “In vitro skin irritation: reconstructed human epidermis test method”

8. Severe eye irritation and corrosion: OECD TG 460 “Fluorescein leakage test method for identifying ocular corrosives and severe irritants”